SCOPe 2.01: Family c.111.1.2: Ubiquitin activating enzymes (UBA)

Lineage for Family c.111.1.2: Ubiquitin activating enzymes (UBA)

1. Root: SCOPe 2.01

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.111: Activating enzymes of the ubiquitin-like proteins [69571] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 32145678; strands 6 and 8 are antiparallel to the rest

4. Superfamily c.111.1: Activating enzymes of the ubiquitin-like proteins [69572] (3 families)
   transfer adenylyl group to the C-terminal carboxyl group of the ubiquitin and MoaD/ThiS-related proteins
   the ATP nucleotide-binding site is similar to that of the NAD-binding Rossmann-folds

5. Family c.111.1.2: Ubiquitin activating enzymes (UBA) [89763] (2 proteins)
   the common fold is elaborated with additional (sub)domains

Proteins:

1. Amyloid beta precursor protein-binding protein 1, APPBP1 [89766] (1 species)
   a subunit of the heterodimeric E1 enzyme for NEDD8; contains a large insertion (residues 170-487) that can be divided into 3 units similar to the UBA3 insertion

   • Species Human (Homo sapiens) [TaxId:9606] [89767] (8 PDB entries)
     Uniprot Q13564

2. UBA3 [89764] (1 species)
   a subunit of the heterodimeric E1 enzyme for NEDD8; contains an all-alpha insert subdomain of the FF-like fold (residues 210-288) and an extra C-terminal alpha+beta subdomain (partly disordered)

   • Species Human (Homo sapiens) [TaxId:9606] [89765] (8 PDB entries)
     Uniprot Q8TBC4 33-458

More info for Family c.111.1.2: Ubiquitin activating enzymes (UBA)

Timeline for Family c.111.1.2: Ubiquitin activating enzymes (UBA):

• Family c.111.1.2: Ubiquitin activating enzymes (UBA) first appeared in SCOP 1.65
  
• Family c.111.1.2: Ubiquitin activating enzymes (UBA) appears in SCOP 1.75
  
• Family c.111.1.2: Ubiquitin activating enzymes (UBA) appears in SCOPe 2.02
  
• Family c.111.1.2: Ubiquitin activating enzymes (UBA) appears in the current release, SCOPe 2.08