Class c: Alpha and beta proteins (a/b) [51349] (147 folds) |
Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily) 3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465 |
Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families) there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules |
Family c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module [88741] (4 proteins) parent family to TK and PFOR heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module automatically mapped to Pfam PF02779 |
Protein E1-beta subunit of pyruvate dehydrogenase, Pyr module [69472] (2 species) |
Species Human (Homo sapiens) [TaxId:9606] [89653] (2 PDB entries) |
Domain d1ni4b1: 1ni4 B:0-191 [85729] Other proteins in same PDB: d1ni4a_, d1ni4b2, d1ni4c_, d1ni4d2 complexed with k, mg, tpp |
Domain d1ni4d1: 1ni4 D:0-191 [85732] Other proteins in same PDB: d1ni4a_, d1ni4b2, d1ni4c_, d1ni4d2 complexed with k, mg, tpp |
Domain d2ozlb1: 2ozl B:0-191 [139447] Other proteins in same PDB: d2ozla1, d2ozlb2, d2ozlc_, d2ozld2 automated match to d1ni4b1 complexed with k, mg, tpp |
Domain d2ozld1: 2ozl D:0-191 [139449] Other proteins in same PDB: d2ozla1, d2ozlb2, d2ozlc_, d2ozld2 automated match to d1ni4b1 complexed with k, mg, tpp |
Timeline for Species Human (Homo sapiens) [TaxId:9606] from c.36.1.7 E1-beta subunit of pyruvate dehydrogenase, Pyr module: