Lineage for Species: Human (Homo sapiens) [TaxId: 9606]

  1. Root: SCOP 1.75
  2. 814173Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 828800Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. 828801Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (8 families) (S)
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
  5. 828995Family c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module [88741] (4 proteins)
    parent family to TK and PFOR
    heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module
  6. 829035Protein E1-beta subunit of pyruvate dehydrogenase, Pyr module [69472] (2 species)
  7. 829038Species Human (Homo sapiens) [TaxId:9606] [89653] (2 PDB entries)

PDB entries in Species: Human (Homo sapiens) [TaxId: 9606]:

  1. Domain(s) for 1ni4:
    1. 829041Domain d1ni4b1: 1ni4 B:0-191 [85729]
      Other proteins in same PDB: d1ni4a_, d1ni4b2, d1ni4c_, d1ni4d2
    2. 829042Domain d1ni4d1: 1ni4 D:0-191 [85732]
      Other proteins in same PDB: d1ni4a_, d1ni4b2, d1ni4c_, d1ni4d2
      complexed with k, mg, mse, tpp; mutant
  2. Domain(s) for 2ozl:
    1. 829039Domain d2ozlb1: 2ozl B:0-191 [139447]
      Other proteins in same PDB: d2ozla1, d2ozlb2, d2ozlc1, d2ozld2
      automatically matched to d1ni4b1
      complexed with k, mg, tpp; mutant
    2. 829040Domain d2ozld1: 2ozl D:0-191 [139449]
      Other proteins in same PDB: d2ozla1, d2ozlb2, d2ozlc1, d2ozld2
      automatically matched to d1ni4b1
      complexed with k, mg, tpp; mutant

More info for Species Human (Homo sapiens) [TaxId:9606] from c.36.1.7 E1-beta subunit of pyruvate dehydrogenase, Pyr module

Timeline for Species Human (Homo sapiens) [TaxId:9606] from c.36.1.7 E1-beta subunit of pyruvate dehydrogenase, Pyr module: