Lineage for Species: Human (Homo sapiens) [TaxId: 9606]

  1. Root: SCOPe 2.05
  2. 1815291Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 1844143Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. 1844144Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families) (S)
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
  5. 1844608Family c.36.1.11: Branched-chain alpha-keto acid dehydrogenase PP module [88766] (5 proteins)
    parent family to TK and PFOR
    heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module
  6. 1844642Protein E1-beta subunit of pyruvate dehydrogenase (PP module) [89651] (1 species)
  7. 1844643Species Human (Homo sapiens) [TaxId:9606] [89652] (7 PDB entries)

PDB entries in Species: Human (Homo sapiens) [TaxId: 9606]:

  1. Domain(s) for 1ni4:
    1. 1844650Domain d1ni4a_: 1ni4 A: [85728]
      Other proteins in same PDB: d1ni4b1, d1ni4b2, d1ni4d1, d1ni4d2
      complexed with k, mg, tpp
    2. 1844651Domain d1ni4c_: 1ni4 C: [85731]
      Other proteins in same PDB: d1ni4b1, d1ni4b2, d1ni4d1, d1ni4d2
      complexed with k, mg, tpp
  2. Domain(s) for 2ozl:
    1. 1844648Domain d2ozla1: 2ozl A:1-361 [145744]
      Other proteins in same PDB: d2ozlb1, d2ozlb2, d2ozld1, d2ozld2
      complexed with k, mg, tpp
    2. 1844649Domain d2ozlc_: 2ozl C: [145745]
      Other proteins in same PDB: d2ozlb1, d2ozlb2, d2ozld1, d2ozld2
      automated match to d1ni4a_
      complexed with k, mg, tpp
  3. Domain(s) for 3exe:
    1. 1844644Domain d3exea_: 3exe A: [209698]
      Other proteins in same PDB: d3exeb1, d3exeb2, d3exed1, d3exed2, d3exef1, d3exef2, d3exeh1, d3exeh2
      automated match to d1ni4a_
      complexed with gol, k, mn, tpp
    2. 1844645Domain d3exec_: 3exe C: [209701]
      Other proteins in same PDB: d3exeb1, d3exeb2, d3exed1, d3exed2, d3exef1, d3exef2, d3exeh1, d3exeh2
      automated match to d1ni4a_
      complexed with gol, k, mn, tpp
    3. 1844646Domain d3exee_: 3exe E: [209704]
      Other proteins in same PDB: d3exeb1, d3exeb2, d3exed1, d3exed2, d3exef1, d3exef2, d3exeh1, d3exeh2
      automated match to d1ni4a_
      complexed with gol, k, mn, tpp
    4. 1844647Domain d3exeg_: 3exe G: [209707]
      Other proteins in same PDB: d3exeb1, d3exeb2, d3exed1, d3exed2, d3exef1, d3exef2, d3exeh1, d3exeh2
      automated match to d1ni4a_
      complexed with gol, k, mn, tpp
  4. Domain(s) for 3exf:
    1. 1844657Domain d3exfa_: 3exf A: [245928]
      Other proteins in same PDB: d3exfb1, d3exfb2, d3exfd1, d3exfd2, d3exff1, d3exff2, d3exfh1, d3exfh2
      automated match to d3exia_
      complexed with k, mg, tpp
    2. 1844658Domain d3exfc_: 3exf C: [245931]
      Other proteins in same PDB: d3exfb1, d3exfb2, d3exfd1, d3exfd2, d3exff1, d3exff2, d3exfh1, d3exfh2
      automated match to d3exia_
      complexed with k, mg, tpp
    3. 1844659Domain d3exfe_: 3exf E: [245934]
      Other proteins in same PDB: d3exfb1, d3exfb2, d3exfd1, d3exfd2, d3exff1, d3exff2, d3exfh1, d3exfh2
      automated match to d3exia_
      complexed with k, mg, tpp
    4. 1844660Domain d3exfg_: 3exf G: [245937]
      Other proteins in same PDB: d3exfb1, d3exfb2, d3exfd1, d3exfd2, d3exff1, d3exff2, d3exfh1, d3exfh2
      automated match to d3exia_
      complexed with k, mg, tpp
  5. Domain(s) for 3exg:
    1. 1844661Domain d3exg1_: 3exg 1: [245940]
      Other proteins in same PDB: d3exg21, d3exg22, d3exg41, d3exg42, d3exg61, d3exg62, d3exgb1, d3exgb2, d3exgd1, d3exgd2, d3exgf1, d3exgf2, d3exgh1, d3exgh2, d3exgj1, d3exgj2, d3exgl1, d3exgl2, d3exgn1, d3exgn2, d3exgp1, d3exgp2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgv1, d3exgv2, d3exgx1, d3exgx2, d3exgz1, d3exgz2
      automated match to d3exia_
      complexed with k
    2. 1844662Domain d3exg3_: 3exg 3: [245943]
      Other proteins in same PDB: d3exg21, d3exg22, d3exg41, d3exg42, d3exg61, d3exg62, d3exgb1, d3exgb2, d3exgd1, d3exgd2, d3exgf1, d3exgf2, d3exgh1, d3exgh2, d3exgj1, d3exgj2, d3exgl1, d3exgl2, d3exgn1, d3exgn2, d3exgp1, d3exgp2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgv1, d3exgv2, d3exgx1, d3exgx2, d3exgz1, d3exgz2
      automated match to d3exia_
      complexed with k
    3. 1844663Domain d3exg5_: 3exg 5: [245946]
      Other proteins in same PDB: d3exg21, d3exg22, d3exg41, d3exg42, d3exg61, d3exg62, d3exgb1, d3exgb2, d3exgd1, d3exgd2, d3exgf1, d3exgf2, d3exgh1, d3exgh2, d3exgj1, d3exgj2, d3exgl1, d3exgl2, d3exgn1, d3exgn2, d3exgp1, d3exgp2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgv1, d3exgv2, d3exgx1, d3exgx2, d3exgz1, d3exgz2
      automated match to d3exia_
      complexed with k
    4. 1844664Domain d3exga_: 3exg A: [245949]
      Other proteins in same PDB: d3exg21, d3exg22, d3exg41, d3exg42, d3exg61, d3exg62, d3exgb1, d3exgb2, d3exgd1, d3exgd2, d3exgf1, d3exgf2, d3exgh1, d3exgh2, d3exgj1, d3exgj2, d3exgl1, d3exgl2, d3exgn1, d3exgn2, d3exgp1, d3exgp2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgv1, d3exgv2, d3exgx1, d3exgx2, d3exgz1, d3exgz2
      automated match to d3exia_
      complexed with k
    5. 1844665Domain d3exgc_: 3exg C: [245952]
      Other proteins in same PDB: d3exg21, d3exg22, d3exg41, d3exg42, d3exg61, d3exg62, d3exgb1, d3exgb2, d3exgd1, d3exgd2, d3exgf1, d3exgf2, d3exgh1, d3exgh2, d3exgj1, d3exgj2, d3exgl1, d3exgl2, d3exgn1, d3exgn2, d3exgp1, d3exgp2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgv1, d3exgv2, d3exgx1, d3exgx2, d3exgz1, d3exgz2
      automated match to d3exia_
      complexed with k
    6. 1844666Domain d3exge_: 3exg E: [245955]
      Other proteins in same PDB: d3exg21, d3exg22, d3exg41, d3exg42, d3exg61, d3exg62, d3exgb1, d3exgb2, d3exgd1, d3exgd2, d3exgf1, d3exgf2, d3exgh1, d3exgh2, d3exgj1, d3exgj2, d3exgl1, d3exgl2, d3exgn1, d3exgn2, d3exgp1, d3exgp2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgv1, d3exgv2, d3exgx1, d3exgx2, d3exgz1, d3exgz2
      automated match to d3exia_
      complexed with k
    7. 1844667Domain d3exgg_: 3exg G: [245958]
      Other proteins in same PDB: d3exg21, d3exg22, d3exg41, d3exg42, d3exg61, d3exg62, d3exgb1, d3exgb2, d3exgd1, d3exgd2, d3exgf1, d3exgf2, d3exgh1, d3exgh2, d3exgj1, d3exgj2, d3exgl1, d3exgl2, d3exgn1, d3exgn2, d3exgp1, d3exgp2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgv1, d3exgv2, d3exgx1, d3exgx2, d3exgz1, d3exgz2
      automated match to d3exia_
      complexed with k
    8. 1844668Domain d3exgi_: 3exg I: [245961]
      Other proteins in same PDB: d3exg21, d3exg22, d3exg41, d3exg42, d3exg61, d3exg62, d3exgb1, d3exgb2, d3exgd1, d3exgd2, d3exgf1, d3exgf2, d3exgh1, d3exgh2, d3exgj1, d3exgj2, d3exgl1, d3exgl2, d3exgn1, d3exgn2, d3exgp1, d3exgp2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgv1, d3exgv2, d3exgx1, d3exgx2, d3exgz1, d3exgz2
      automated match to d3exia_
      complexed with k
    9. 1844669Domain d3exgk_: 3exg K: [245964]
      Other proteins in same PDB: d3exg21, d3exg22, d3exg41, d3exg42, d3exg61, d3exg62, d3exgb1, d3exgb2, d3exgd1, d3exgd2, d3exgf1, d3exgf2, d3exgh1, d3exgh2, d3exgj1, d3exgj2, d3exgl1, d3exgl2, d3exgn1, d3exgn2, d3exgp1, d3exgp2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgv1, d3exgv2, d3exgx1, d3exgx2, d3exgz1, d3exgz2
      automated match to d3exia_
      complexed with k
    10. 1844670Domain d3exgm_: 3exg M: [245967]
      Other proteins in same PDB: d3exg21, d3exg22, d3exg41, d3exg42, d3exg61, d3exg62, d3exgb1, d3exgb2, d3exgd1, d3exgd2, d3exgf1, d3exgf2, d3exgh1, d3exgh2, d3exgj1, d3exgj2, d3exgl1, d3exgl2, d3exgn1, d3exgn2, d3exgp1, d3exgp2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgv1, d3exgv2, d3exgx1, d3exgx2, d3exgz1, d3exgz2
      automated match to d3exia_
      complexed with k
    11. 1844671Domain d3exgo_: 3exg O: [245970]
      Other proteins in same PDB: d3exg21, d3exg22, d3exg41, d3exg42, d3exg61, d3exg62, d3exgb1, d3exgb2, d3exgd1, d3exgd2, d3exgf1, d3exgf2, d3exgh1, d3exgh2, d3exgj1, d3exgj2, d3exgl1, d3exgl2, d3exgn1, d3exgn2, d3exgp1, d3exgp2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgv1, d3exgv2, d3exgx1, d3exgx2, d3exgz1, d3exgz2
      automated match to d3exia_
      complexed with k
    12. 1844672Domain d3exgq_: 3exg Q: [245973]
      Other proteins in same PDB: d3exg21, d3exg22, d3exg41, d3exg42, d3exg61, d3exg62, d3exgb1, d3exgb2, d3exgd1, d3exgd2, d3exgf1, d3exgf2, d3exgh1, d3exgh2, d3exgj1, d3exgj2, d3exgl1, d3exgl2, d3exgn1, d3exgn2, d3exgp1, d3exgp2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgv1, d3exgv2, d3exgx1, d3exgx2, d3exgz1, d3exgz2
      automated match to d3exia_
      complexed with k
    13. 1844673Domain d3exgs_: 3exg S: [245976]
      Other proteins in same PDB: d3exg21, d3exg22, d3exg41, d3exg42, d3exg61, d3exg62, d3exgb1, d3exgb2, d3exgd1, d3exgd2, d3exgf1, d3exgf2, d3exgh1, d3exgh2, d3exgj1, d3exgj2, d3exgl1, d3exgl2, d3exgn1, d3exgn2, d3exgp1, d3exgp2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgv1, d3exgv2, d3exgx1, d3exgx2, d3exgz1, d3exgz2
      automated match to d3exia_
      complexed with k
    14. 1844674Domain d3exgu_: 3exg U: [245979]
      Other proteins in same PDB: d3exg21, d3exg22, d3exg41, d3exg42, d3exg61, d3exg62, d3exgb1, d3exgb2, d3exgd1, d3exgd2, d3exgf1, d3exgf2, d3exgh1, d3exgh2, d3exgj1, d3exgj2, d3exgl1, d3exgl2, d3exgn1, d3exgn2, d3exgp1, d3exgp2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgv1, d3exgv2, d3exgx1, d3exgx2, d3exgz1, d3exgz2
      automated match to d3exia_
      complexed with k
    15. 1844675Domain d3exgw_: 3exg W: [245982]
      Other proteins in same PDB: d3exg21, d3exg22, d3exg41, d3exg42, d3exg61, d3exg62, d3exgb1, d3exgb2, d3exgd1, d3exgd2, d3exgf1, d3exgf2, d3exgh1, d3exgh2, d3exgj1, d3exgj2, d3exgl1, d3exgl2, d3exgn1, d3exgn2, d3exgp1, d3exgp2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgv1, d3exgv2, d3exgx1, d3exgx2, d3exgz1, d3exgz2
      automated match to d3exia_
      complexed with k
    16. 1844676Domain d3exgy_: 3exg Y: [245985]
      Other proteins in same PDB: d3exg21, d3exg22, d3exg41, d3exg42, d3exg61, d3exg62, d3exgb1, d3exgb2, d3exgd1, d3exgd2, d3exgf1, d3exgf2, d3exgh1, d3exgh2, d3exgj1, d3exgj2, d3exgl1, d3exgl2, d3exgn1, d3exgn2, d3exgp1, d3exgp2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgv1, d3exgv2, d3exgx1, d3exgx2, d3exgz1, d3exgz2
      automated match to d3exia_
      complexed with k
  6. Domain(s) for 3exh:
    1. 1844653Domain d3exha_: 3exh A: [209710]
      Other proteins in same PDB: d3exhb1, d3exhb2, d3exhd1, d3exhd2, d3exhf1, d3exhf2, d3exhh1, d3exhh2
      automated match to d1ni4a_
      complexed with gol, k, mn, tpp
    2. 1844654Domain d3exhc_: 3exh C: [209713]
      Other proteins in same PDB: d3exhb1, d3exhb2, d3exhd1, d3exhd2, d3exhf1, d3exhf2, d3exhh1, d3exhh2
      automated match to d1ni4a_
      complexed with gol, k, mn, tpp
    3. 1844655Domain d3exhe_: 3exh E: [209716]
      Other proteins in same PDB: d3exhb1, d3exhb2, d3exhd1, d3exhd2, d3exhf1, d3exhf2, d3exhh1, d3exhh2
      automated match to d1ni4a_
      complexed with gol, k, mn, tpp
    4. 1844656Domain d3exhg_: 3exh G: [209719]
      Other proteins in same PDB: d3exhb1, d3exhb2, d3exhd1, d3exhd2, d3exhf1, d3exhf2, d3exhh1, d3exhh2
      automated match to d1ni4a_
      complexed with gol, k, mn, tpp
  7. Domain(s) for 3exi:

More info for Species Human (Homo sapiens) [TaxId:9606] from c.36.1.11 E1-beta subunit of pyruvate dehydrogenase (PP module)

Timeline for Species Human (Homo sapiens) [TaxId:9606] from c.36.1.11 E1-beta subunit of pyruvate dehydrogenase (PP module):