Lineage for Species: Human (Homo sapiens) [TaxId: 9606]

  1. Root: SCOPe 2.03
  2. 1336837Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 1361462Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. 1361463Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families) (S)
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
  5. 1361943Family c.36.1.11: Branched-chain alpha-keto acid dehydrogenase PP module [88766] (5 proteins)
    parent family to TK and PFOR
    heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module
  6. 1361977Protein E1-beta subunit of pyruvate dehydrogenase (PP module) [89651] (1 species)
  7. 1361978Species Human (Homo sapiens) [TaxId:9606] [89652] (5 PDB entries)

PDB entries in Species: Human (Homo sapiens) [TaxId: 9606]:

  1. Domain(s) for 1ni4:
    1. 1361985Domain d1ni4a_: 1ni4 A: [85728]
      Other proteins in same PDB: d1ni4b1, d1ni4b2, d1ni4d1, d1ni4d2
      complexed with k, mg, tpp
    2. 1361986Domain d1ni4c_: 1ni4 C: [85731]
      Other proteins in same PDB: d1ni4b1, d1ni4b2, d1ni4d1, d1ni4d2
      complexed with k, mg, tpp
  2. Domain(s) for 2ozl:
    1. 1361983Domain d2ozla1: 2ozl A:1-361 [145744]
      Other proteins in same PDB: d2ozlb1, d2ozlb2, d2ozld1, d2ozld2
      complexed with k, mg, tpp
    2. 1361984Domain d2ozlc_: 2ozl C: [145745]
      Other proteins in same PDB: d2ozlb1, d2ozlb2, d2ozld1, d2ozld2
      automated match to d1ni4a_
      complexed with k, mg, tpp
  3. Domain(s) for 3exe:
    1. 1361979Domain d3exea_: 3exe A: [209698]
      Other proteins in same PDB: d3exeb1, d3exeb2, d3exed1, d3exed2, d3exef1, d3exef2, d3exeh1, d3exeh2
      automated match to d1ni4a_
      complexed with gol, k, mn, tpp
    2. 1361980Domain d3exec_: 3exe C: [209701]
      Other proteins in same PDB: d3exeb1, d3exeb2, d3exed1, d3exed2, d3exef1, d3exef2, d3exeh1, d3exeh2
      automated match to d1ni4a_
      complexed with gol, k, mn, tpp
    3. 1361981Domain d3exee_: 3exe E: [209704]
      Other proteins in same PDB: d3exeb1, d3exeb2, d3exed1, d3exed2, d3exef1, d3exef2, d3exeh1, d3exeh2
      automated match to d1ni4a_
      complexed with gol, k, mn, tpp
    4. 1361982Domain d3exeg_: 3exe G: [209707]
      Other proteins in same PDB: d3exeb1, d3exeb2, d3exed1, d3exed2, d3exef1, d3exef2, d3exeh1, d3exeh2
      automated match to d1ni4a_
      complexed with gol, k, mn, tpp
  4. Domain(s) for 3exh:
    1. 1361988Domain d3exha_: 3exh A: [209710]
      Other proteins in same PDB: d3exhb1, d3exhb2, d3exhd1, d3exhd2, d3exhf1, d3exhf2, d3exhh1, d3exhh2
      automated match to d1ni4a_
      complexed with gol, k, mn, tpp
    2. 1361989Domain d3exhc_: 3exh C: [209713]
      Other proteins in same PDB: d3exhb1, d3exhb2, d3exhd1, d3exhd2, d3exhf1, d3exhf2, d3exhh1, d3exhh2
      automated match to d1ni4a_
      complexed with gol, k, mn, tpp
    3. 1361990Domain d3exhe_: 3exh E: [209716]
      Other proteins in same PDB: d3exhb1, d3exhb2, d3exhd1, d3exhd2, d3exhf1, d3exhf2, d3exhh1, d3exhh2
      automated match to d1ni4a_
      complexed with gol, k, mn, tpp
    4. 1361991Domain d3exhg_: 3exh G: [209719]
      Other proteins in same PDB: d3exhb1, d3exhb2, d3exhd1, d3exhd2, d3exhf1, d3exhf2, d3exhh1, d3exhh2
      automated match to d1ni4a_
      complexed with gol, k, mn, tpp
  5. Domain(s) for 3exi:

More info for Species Human (Homo sapiens) [TaxId:9606] from c.36.1.11 E1-beta subunit of pyruvate dehydrogenase (PP module)

Timeline for Species Human (Homo sapiens) [TaxId:9606] from c.36.1.11 E1-beta subunit of pyruvate dehydrogenase (PP module):