![]() | Class c: Alpha and beta proteins (a/b) [51349] (147 folds) |
![]() | Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily) 3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465 |
![]() | Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families) ![]() there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules |
![]() | Family c.36.1.11: Branched-chain alpha-keto acid dehydrogenase PP module [88766] (5 proteins) parent family to TK and PFOR heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module |
![]() | Protein E1-beta subunit of pyruvate dehydrogenase (PP module) [89651] (1 species) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [89652] (5 PDB entries) |
![]() | Domain d1ni4a_: 1ni4 A: [85728] Other proteins in same PDB: d1ni4b1, d1ni4b2, d1ni4d1, d1ni4d2 complexed with k, mg, tpp |
![]() | Domain d1ni4c_: 1ni4 C: [85731] Other proteins in same PDB: d1ni4b1, d1ni4b2, d1ni4d1, d1ni4d2 complexed with k, mg, tpp |
![]() | Domain d3exea_: 3exe A: [209698] Other proteins in same PDB: d3exeb1, d3exeb2, d3exed1, d3exed2, d3exef1, d3exef2, d3exeh1, d3exeh2 automated match to d1ni4a_ complexed with gol, k, mn, tpp |
![]() | Domain d3exec_: 3exe C: [209701] Other proteins in same PDB: d3exeb1, d3exeb2, d3exed1, d3exed2, d3exef1, d3exef2, d3exeh1, d3exeh2 automated match to d1ni4a_ complexed with gol, k, mn, tpp |
![]() | Domain d3exee_: 3exe E: [209704] Other proteins in same PDB: d3exeb1, d3exeb2, d3exed1, d3exed2, d3exef1, d3exef2, d3exeh1, d3exeh2 automated match to d1ni4a_ complexed with gol, k, mn, tpp |
![]() | Domain d3exeg_: 3exe G: [209707] Other proteins in same PDB: d3exeb1, d3exeb2, d3exed1, d3exed2, d3exef1, d3exef2, d3exeh1, d3exeh2 automated match to d1ni4a_ complexed with gol, k, mn, tpp |
![]() | Domain d3exha_: 3exh A: [209710] Other proteins in same PDB: d3exhb1, d3exhb2, d3exhd1, d3exhd2, d3exhf1, d3exhf2, d3exhh1, d3exhh2 automated match to d1ni4a_ complexed with gol, k, mn, tpp |
![]() | Domain d3exhc_: 3exh C: [209713] Other proteins in same PDB: d3exhb1, d3exhb2, d3exhd1, d3exhd2, d3exhf1, d3exhf2, d3exhh1, d3exhh2 automated match to d1ni4a_ complexed with gol, k, mn, tpp |
![]() | Domain d3exhe_: 3exh E: [209716] Other proteins in same PDB: d3exhb1, d3exhb2, d3exhd1, d3exhd2, d3exhf1, d3exhf2, d3exhh1, d3exhh2 automated match to d1ni4a_ complexed with gol, k, mn, tpp |
![]() | Domain d3exhg_: 3exh G: [209719] Other proteins in same PDB: d3exhb1, d3exhb2, d3exhd1, d3exhd2, d3exhf1, d3exhf2, d3exhh1, d3exhh2 automated match to d1ni4a_ complexed with gol, k, mn, tpp |
![]() | Domain d3exia_: 3exi A: [209722] Other proteins in same PDB: d3exib1, d3exib2 automated match to d1ni4a_ complexed with cl, k |
Timeline for Species Human (Homo sapiens) [TaxId:9606] from c.36.1.11 E1-beta subunit of pyruvate dehydrogenase (PP module):