Lineage for Species: Human (Homo sapiens) [TaxId: 9606]

  1. Root: SCOP 1.75
  2. 814173Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 828800Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. 828801Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (8 families) (S)
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
  5. 829269Family c.36.1.11: Branched-chain alpha-keto acid dehydrogenase PP module [88766] (4 proteins)
    parent family to TK and PFOR
    heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module
  6. 829311Protein E1-beta subunit of pyruvate dehydrogenase (PP module) [89651] (1 species)
  7. 829312Species Human (Homo sapiens) [TaxId:9606] [89652] (2 PDB entries)

PDB entries in Species: Human (Homo sapiens) [TaxId: 9606]:

  1. Domain(s) for 1ni4:
    1. 829315Domain d1ni4a_: 1ni4 A: [85728]
      Other proteins in same PDB: d1ni4b1, d1ni4b2, d1ni4d1, d1ni4d2
    2. 829316Domain d1ni4c_: 1ni4 C: [85731]
      Other proteins in same PDB: d1ni4b1, d1ni4b2, d1ni4d1, d1ni4d2
      complexed with k, mg, mse, tpp; mutant
  2. Domain(s) for 2ozl:
    1. 829313Domain d2ozla1: 2ozl A:1-361 [145744]
      Other proteins in same PDB: d2ozlb1, d2ozlb2, d2ozld1, d2ozld2
      complexed with k, mg, tpp; mutant
    2. 829314Domain d2ozlc1: 2ozl C:1-361 [145745]
      Other proteins in same PDB: d2ozlb1, d2ozlb2, d2ozld1, d2ozld2
      automatically matched to 2OZL A:1-361
      complexed with k, mg, tpp; mutant

More info for Species Human (Homo sapiens) [TaxId:9606] from c.36.1.11 E1-beta subunit of pyruvate dehydrogenase (PP module)

Timeline for Species Human (Homo sapiens) [TaxId:9606] from c.36.1.11 E1-beta subunit of pyruvate dehydrogenase (PP module):