SCOPe 2.08: Protein: Shikimate 5-dehydrogenase AroE

Lineage for Protein: Shikimate 5-dehydrogenase AroE

Root: SCOPe 2.08
Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
The nucleotide-binding modes of this and the next two folds/superfamilies are similar

Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

Family c.2.1.7: Aminoacid dehydrogenase-like, C-terminal domain [51883] (12 proteins)
extra N-terminal helix displaces the C-terminal helix (following strand 6) from its usual position creating a family nicotineamide-binding site

Protein Shikimate 5-dehydrogenase AroE [89538] (6 species)

Species:

Aquifex aeolicus [TaxId:63363] [225281] (3 PDB entries)
1. Domains for 2hk7:
  1. Domain d2hk7a2: 2hk7 A:106-269 [204591]
    Other proteins in same PDB: d2hk7a1, d2hk7b1
    automated match to d1nvta1
    complexed with hg
  2. Domain d2hk7b2: 2hk7 B:106-268 [204593]
    Other proteins in same PDB: d2hk7a1, d2hk7b1
    automated match to d1nvta1
    complexed with hg
2. Domains for 2hk8:
  1. Domain d2hk8a2: 2hk8 A:106-266 [204595]
    Other proteins in same PDB: d2hk8a1, d2hk8b1, d2hk8c1, d2hk8d1, d2hk8e1, d2hk8f1, d2hk8g1, d2hk8h1
    automated match to d1nvta1
  2. Domain d2hk8b2: 2hk8 B:106-266 [204597]
    Other proteins in same PDB: d2hk8a1, d2hk8b1, d2hk8c1, d2hk8d1, d2hk8e1, d2hk8f1, d2hk8g1, d2hk8h1
    automated match to d1nvta1
  3. Domain d2hk8c2: 2hk8 C:106-265 [204599]
    Other proteins in same PDB: d2hk8a1, d2hk8b1, d2hk8c1, d2hk8d1, d2hk8e1, d2hk8f1, d2hk8g1, d2hk8h1
    automated match to d1nvta1
  4. Domain d2hk8d2: 2hk8 D:106-266 [204601]
    Other proteins in same PDB: d2hk8a1, d2hk8b1, d2hk8c1, d2hk8d1, d2hk8e1, d2hk8f1, d2hk8g1, d2hk8h1
    automated match to d1nvta1
  5. Domain d2hk8e2: 2hk8 E:106-266 [204603]
    Other proteins in same PDB: d2hk8a1, d2hk8b1, d2hk8c1, d2hk8d1, d2hk8e1, d2hk8f1, d2hk8g1, d2hk8h1
    automated match to d1nvta1
  6. Domain d2hk8f2: 2hk8 F:106-264 [204605]
    Other proteins in same PDB: d2hk8a1, d2hk8b1, d2hk8c1, d2hk8d1, d2hk8e1, d2hk8f1, d2hk8g1, d2hk8h1
    automated match to d1nvta1
  7. Domain d2hk8g2: 2hk8 G:106-266 [204607]
    Other proteins in same PDB: d2hk8a1, d2hk8b1, d2hk8c1, d2hk8d1, d2hk8e1, d2hk8f1, d2hk8g1, d2hk8h1
    automated match to d1nvta1
  8. Domain d2hk8h2: 2hk8 H:106-266 [204609]
    Other proteins in same PDB: d2hk8a1, d2hk8b1, d2hk8c1, d2hk8d1, d2hk8e1, d2hk8f1, d2hk8g1, d2hk8h1
    automated match to d1nvta1
3. Domains for 2hk9:
  1. Domain d2hk9a2: 2hk9 A:106-269 [204611]
    Other proteins in same PDB: d2hk9a1, d2hk9b1, d2hk9c1, d2hk9d1
    automated match to d1nvta1
    complexed with atr, nap, skm
  2. Domain d2hk9b2: 2hk9 B:106-267 [204613]
    Other proteins in same PDB: d2hk9a1, d2hk9b1, d2hk9c1, d2hk9d1
    automated match to d1nvta1
    complexed with atr, nap, skm
  3. Domain d2hk9c2: 2hk9 C:106-266 [204615]
    Other proteins in same PDB: d2hk9a1, d2hk9b1, d2hk9c1, d2hk9d1
    automated match to d1nvta1
    complexed with atr, nap, skm
  4. Domain d2hk9d2: 2hk9 D:106-266 [204617]
    Other proteins in same PDB: d2hk9a1, d2hk9b1, d2hk9c1, d2hk9d1
    automated match to d1nvta1
    complexed with atr, nap, skm
Escherichia coli [TaxId:562] [89539] (1 PDB entry)
- Domains for 1nyt:
  1. Domain d1nyta1: 1nyt A:102-271 [86417]
    Other proteins in same PDB: d1nyta2, d1nytb2, d1nytc2, d1nytd2
    complexed with dtv, nap, so4
  2. Domain d1nytb1: 1nyt B:102-271 [86419]
    Other proteins in same PDB: d1nyta2, d1nytb2, d1nytc2, d1nytd2
    complexed with dtv, nap, so4
  3. Domain d1nytc1: 1nyt C:102-269 [86421]
    Other proteins in same PDB: d1nyta2, d1nytb2, d1nytc2, d1nytd2
    complexed with dtv, nap, so4
  4. Domain d1nytd1: 1nyt D:102-270 [86423]
    Other proteins in same PDB: d1nyta2, d1nytb2, d1nytc2, d1nytd2
    complexed with dtv, nap, so4

Geobacillus kaustophilus [TaxId:1462] [225426] (1 PDB entry)

Domains for 2egg:

Domain d2egga2: 2egg A:123-297 [204117]
Other proteins in same PDB: d2egga1, d2egga3, d2eggb1, d2eggb3
automated match to d1nvta1
complexed with cl

Domain d2eggb2: 2egg B:123-296 [204119]
Other proteins in same PDB: d2egga1, d2egga3, d2eggb1, d2eggb3
automated match to d1nvta1
complexed with cl
fragment; missing more than one-third of the common structure and/or sequence

Haemophilus influenzae [TaxId:727] [102173] (2 PDB entries)
1. Domains for 1p74:
  1. Domain d1p74a1: 1p74 A:102-272 [94206]
    Other proteins in same PDB: d1p74a2, d1p74b2
  2. Domain d1p74b1: 1p74 B:102-272 [94208]
    Other proteins in same PDB: d1p74a2, d1p74b2
2. Domain for 1p77:
  - Domain d1p77a1: 1p77 A:102-272 [94214]
    Other proteins in same PDB: d1p77a2
    complexed with act, atr
Methanococcus jannaschii [TaxId:2190] [89540] (1 PDB entry)
MJ1084
- Domains for 1nvt:
  1. Domain d1nvta1: 1nvt A:111-287 [86270]
    Other proteins in same PDB: d1nvta2, d1nvta3, d1nvtb2, d1nvtb3
    structural genomics
    complexed with nap, zn
  2. Domain d1nvtb1: 1nvt B:111-287 [86272]
    Other proteins in same PDB: d1nvta2, d1nvta3, d1nvtb2, d1nvtb3
    structural genomics
    complexed with nap, zn
Staphylococcus epidermidis [TaxId:176279] [225658] (2 PDB entries)
1. Domain for 3don:
  - Domain d3dona2: 3don A:100-269 [209245]
    Other proteins in same PDB: d3dona1, d3dona3
    automated match to d1p77a1
    complexed with gol
2. Domain for 3doo:
  - Domain d3dooa2: 3doo A:100-267 [209247]
    Other proteins in same PDB: d3dooa1
    automated match to d1p77a1
    complexed with skm

More info for Protein Shikimate 5-dehydrogenase AroE from c.2.1.7: Aminoacid dehydrogenase-like, C-terminal domain

Timeline for Protein Shikimate 5-dehydrogenase AroE from c.2.1.7: Aminoacid dehydrogenase-like, C-terminal domain:

Protein Shikimate 5-dehydrogenase AroE from c.2.1.7: Aminoacid dehydrogenase-like, C-terminal domain first appeared in SCOP 1.65
Protein Shikimate 5-dehydrogenase AroE from c.2.1.7: Aminoacid dehydrogenase-like, C-terminal domain appears in SCOPe 2.07