Lineage for Family d.144.1.7: Protein kinases, catalytic subunit

  1. Root: SCOP 1.69
  2. 496776Class d: Alpha and beta proteins (a+b) [53931] (279 folds)
  3. 511959Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 511960Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (7 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 512001Family d.144.1.7: Protein kinases, catalytic subunit [88854] (53 proteins)
    members organized in the groups and subfamiles specified by the comments

Proteins:

  1. 5120023-phosphoinositide dependent protein kinase-1 Pdk1 [90036] (1 species)
    AGC group; PBK subfamily; serine/threonine kinase
  2. 512012Abelsone tyrosine kinase (abl) [56166] (1 species)
    PTK group; Abl subfamily; non-membrane spanning protein tyrosine kinase
  3. 512025Activated CDC42 kinase 1, ACK1 [111200] (1 species)
    PTK group; Tck subfamily; non-membrane spanning protein tyrosine kinase
  4. 512033Aurora-related kinase 1 (aurora-2) [90038] (1 species)
    OPK group; AIRK subfamily; serine/threonine kinase
  5. 512040B-Raf kinase [103290] (1 species)
    OPK group; RAF subfamily; serine/threonine kinase; possible evolutionary link to tyrosine kinases
  6. 512046Bruton's tyrosine kinase (Btk) [75564] (1 species)
    PTK group; Tec/Atk subfamily; non-membrane spanning protein tyrosine kinase
  7. 512050c-jun N-terminal kinase (jnk3s) [56137] (1 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
  8. 512057c-KIT receptor [103296] (1 species)
    PTK group; PDGFR/VEGFR subfamily; membrane spanning protein tyrosine kinase
  9. 512063c-src tyrosine kinase [56155] (2 species)
    PTK group; Src subfamily; non-membrane spanning protein tyrosine kinase
    1. 512064Species Chicken (Gallus gallus) [TaxId:9031] [56157] (1 PDB entry)
    2. 512066Species Human (Homo sapiens) [TaxId:9606] [56156] (3 PDB entries)
  10. 512070Calmodulin-dependent protein kinase [56120] (1 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase
  11. 512073cAMP-dependent PK, catalytic subunit [56116] (4 species)
    AGC group; PKA subfamily; serine/threonine kinase
    1. 512074Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [64403] (1 PDB entry)
    2. 512076Species Cow (Bos taurus) [TaxId:9913] [56118] (12 PDB entries)
    3. 512090Species Mouse (Mus musculus) [TaxId:10090] [56119] (14 PDB entries)
    4. 512106Species Pig (Sus scrofa) [TaxId:9823] [56117] (3 PDB entries)
  12. 512111Carboxyl-terminal src kinase (csk) [56164] (1 species)
    PTK group; CSK subfamily; non-membrane spanning protein tyrosine kinase
  13. 512120Casein kinase-1, CK1 [56139] (2 species)
    OPK group; CKI subfamily; serine/threonine kinase
    1. 512121Species Fission yeast (Schizosaccharomyces pombe) [TaxId:4896] [56141] (3 PDB entries)
    2. 512126Species Rat (Rattus norvegicus) [TaxId:10116] [56140] (2 PDB entries)
  14. 512131Cell cycle checkpoint kinase chk1 [64404] (1 species)
    CaMK group; CAMKL subfamily; serine/threonine kinase
  15. 512137Cyclin-dependent PK, CDK2 [88855] (2 species)
    CMGC group; CDKs subfamily; serine/threonine kinase
    1. 512138Species (Plasmodium falciparum) [103289] (4 PDB entries)
      CDK2 homologue Pfpk5
    2. 512147Species Human (Homo sapiens) [TaxId:9606] [88856] (79 PDB entries)
  16. 512255Cyclin-dependent PK, CDK5 [88857] (1 species)
    CMGC group; CDKs subfamily; serine/threonine kinase
  17. 512259Cyclin-dependent PK, CDK6 [88859] (1 species)
    CMGC group; CDKs subfamily; serine/threonine kinase
  18. 512268Death-associated protein kinase, Dap [75560] (1 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase
  19. 512277EGF receptor tyrosine kinase, Erbb-1 [82795] (1 species)
    PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase
  20. 512281epha2 receptor tyrosine kinase [103294] (1 species)
    PTK group; Eph/Elk/Eck subfamily; membrane spanning protein tyrosine kinase
  21. 512285ephb2 receptor tyrosine kinase [69827] (1 species)
    PTK group; Eph/Elk/Eck subfamily; membrane spanning protein tyrosine kinase
  22. 512289Fibroblast growth factor receptor 1 [56158] (1 species)
    PTK group; FGFR subfamily; membrane spanning protein tyrosine kinase
  23. 512299Fibroblast growth factor receptor 2 [75562] (1 species)
    PTK group; FGFR subfamily; membrane spanning protein tyrosine kinase
  24. 512302Fl cytokine receptor [103298] (1 species)
    PTK group; CSF-1/PDGF receptor subfamily; membrane spanning protein tyrosine kinase
  25. 512305Focal adhesion kinase 1 (fak) [103292] (1 species)
    PTK group; FAK subfamily; non-membrane spanning protein tyrosine kinase
  26. 512308G-protein coupled receptor kinase 2 [90034] (1 species)
    AGC group; GRKs subfamily; serine/threonine kinase
  27. 512311gamma-subunit of glycogen phosphorylase kinase (Phk) [56122] (1 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase
  28. 512316Glycogen synthase kinase-3 beta (Gsk3b) [69823] (1 species)
    CMGC group; GSK3 subfamily; serine/threonine kinase
  29. 512342Haemopoetic cell kinase Hck [56151] (1 species)
    PTK group; Src subfamily; non-membrane spanning protein tyrosine kinase
  30. 512349Hepatocyte growth factor receptor, c-MET [103300] (1 species)
    PTK group; HGFR subfamily; membrane spanning protein tyrosine kinase
  31. 512353Insulin receptor [56162] (1 species)
    PTK group; InsR subfamily; membrane spanning protein tyrosine kinase
  32. 512362Insulin-like growth factor 1 receptor [69825] (1 species)
    PTK group; InsR subfamily; membrane spanning protein tyrosine kinase
  33. 512372Lymphocyte kinase (lck) [56153] (1 species)
    PTK group; Src subfamily; non-membrane spanning protein tyrosine kinase
  34. 512379MAP kinase activated protein kinase 2, mapkap2 [82789] (1 species)
    CaMK group; MAPKAPK subfamily; serine/threonine kinase
  35. 512388MAP kinase Erk2 [56134] (2 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
    1. 512389Species Human (Homo sapiens) [TaxId:9606] [56135] (1 PDB entry)
    2. 512391Species Rat (Rattus norvegicus) [TaxId:10116] [56136] (5 PDB entries)
  36. 512397MAP kinase p38 [56129] (2 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
    1. 512398Species Human (Homo sapiens) [TaxId:9606] [56130] (16 PDB entries)
    2. 512415Species Mouse (Mus musculus) [TaxId:10090] [56131] (3 PDB entries)
  37. 512419MAP kinase p38-gamma [56132] (1 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
  38. 512423Mitogen-activated protein kinase 8 (jnk1) [111202] (1 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
  39. 512427Musk tyrosine kinase [82797] (1 species)
    PTK group; MUSK subfamily; non-membrane spanning protein tyrosine kinase
  40. 512430Mycobacterial protein kinase PknB, catalytic domain [82793] (1 species)
    OPK group; PKN subfamily; serine/threonine kinase
  41. 512435pak1 [56146] (1 species)
    OPK group; PAK/STE20 subfamily; serine/threonine kinase
  42. 512439Pkb kinase (Akt-2) [82791] (1 species)
    AGC group; RAC/Akt subfamily; serine/threonine kinase
  43. 512448Protein kinase CK2, alpha subunit [56142] (2 species)
    CMGC group; CK2 subfamily; serine/threonine kinase
    1. 512449Species Human (Homo sapiens) [TaxId:9606] [75559] (3 PDB entries)
    2. 512454Species Maize (Zea mays) [TaxId:4577] [56143] (13 PDB entries)
  44. 512472Protein kinase wnk1 [111196] (1 species)
    OPK group; WNK subfamily; serine/threonine kinase
  45. 512476Ribosomal protein S6 kinase alpha 5, Msk1 [111192] (1 species)
    AGC group (?); S6 kinase subfamily; serine/threonine kinase
  46. 512479Sky1p [56148] (1 species)
    CMGC group; Clk subfamily; serine/threonine kinase
  47. 512490Tie2 kinase [64406] (1 species)
    PTK group; Tie/Tck subfamily; membrane spanning protein tyrosine kinase
  48. 512494Titin, kinase domain [56124] (1 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase
  49. 512498Twitchin, kinase domain [56126] (2 species)
    CaMK group; CAMKI subfamily; serine/threonine kinase
    1. 512499Species Caenorhabditis elegans, pjk4 [TaxId:6239] [56128] (1 PDB entry)
    2. 512501Species California sea hare (Aplysia californica), twk43 [TaxId:6500] [56127] (1 PDB entry)
  50. 512504Type I TGF-beta receptor R4 [56144] (1 species)
    TKL group; STKR subfamily; serine/threonine kinase; possible evolutionary link to tyrosine kinases
  51. 512517Tyrosine-protein kinase Itk/Tsk [111194] (1 species)
    PTK group; Tec/Atk subfamily; non-membrane spanning protein tyrosine kinase
  52. 512525Tyrosine-protein kinase ZAP-70 [111198] (1 species)
    PTK group; SYK/ZAP-70 subfamily; non-membrane spanning protein tyrosine kinase
  53. 512528Vascular endothelial growth factor receptor 2 (kdr) [56160] (1 species)
    PTK group; PDGFR/VEGFR subfamily; membrane spanning protein tyrosine kinase

More info for Family d.144.1.7: Protein kinases, catalytic subunit

Timeline for Family d.144.1.7: Protein kinases, catalytic subunit: