SCOP 1.67: Species: Human (Homo sapiens)

Lineage for Species: Human (Homo sapiens)

Root: SCOP 1.67
Class c: Alpha and beta proteins (a/b) [51349] (130 folds)
Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (8 families)

there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules

Family c.36.1.11: Branched-chain alpha-keto acid dehydrogenase PP module [88766] (3 proteins)
parent family to TK and PFOR
heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module

Protein Branched-chain alpha-keto acid dehydrogenase, PP module [88767] (2 species)
Species Human (Homo sapiens) [TaxId:9606] [88768] (4 PDB entries)

PDB entries in Species: Human (Homo sapiens):

Domain(s) for 1dtw:
- Domain d1dtwa_: 1dtw A: [31827]
  Other proteins in same PDB: d1dtwb1, d1dtwb2
  complexed with k, mg, tdp
Domain(s) for 1ols:
- Domain d1olsa_: 1ols A: [93331]
  Other proteins in same PDB: d1olsb1, d1olsb2
  complexed with gol, k, mn, tdp
Domain(s) for 1olu:
- Domain d1olua_: 1olu A: [93335]
  Other proteins in same PDB: d1olub1, d1olub2
  complexed with gol, k, mg, tdp; mutant
Domain(s) for 1olx:
- Domain d1olxa_: 1olx A: [93338]
  Other proteins in same PDB: d1olxb1, d1olxb2
  complexed with gol, k, mn, tdp; mutant

More info for Species Human (Homo sapiens) [TaxId:9606] from c.36.1.11 Branched-chain alpha-keto acid dehydrogenase, PP module

Timeline for Species Human (Homo sapiens) [TaxId:9606] from c.36.1.11 Branched-chain alpha-keto acid dehydrogenase, PP module:

Species Human (Homo sapiens) [TaxId:9606] from c.36.1.11 Branched-chain alpha-keto acid dehydrogenase, PP module first appeared in SCOP 1.65
Species Human (Homo sapiens) [TaxId:9606] from c.36.1.11 Branched-chain alpha-keto acid dehydrogenase, PP module appears in SCOP 1.69
Species Human (Homo sapiens) [TaxId:9606] from c.36.1.11 Branched-chain alpha-keto acid dehydrogenase, PP module appears in the current release, SCOPe 2.08