![]() | Class c: Alpha and beta proteins (a/b) [51349] (148 folds) |
![]() | Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily) 3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465 |
![]() | Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families) ![]() there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules |
![]() | Family c.36.1.11: Branched-chain alpha-keto acid dehydrogenase PP module [88766] (5 proteins) parent family to TK and PFOR heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module |
![]() | 2-oxoisovalerate dehydrogenase (E1B), PP module [88769] (1 species) chain A is alpha-subunit and chain B is beta-subunit |
![]() | Species Pseudomonas putida [TaxId:303] [88770] (1 PDB entry) |
![]() | Branched-chain alpha-keto acid dehydrogenase, PP module [88767] (2 species) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [88768] (19 PDB entries) Uniprot P12694 52-445 |
![]() | Species Thermus thermophilus [TaxId:274] [102337] (4 PDB entries) |
![]() | E1-beta subunit of pyruvate dehydrogenase (PP module) [89651] (1 species) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [89652] (7 PDB entries) |
![]() | Pyruvate dehydrogenase E1-alpha, PdhA [117525] (1 species) |
![]() | Species Bacillus stearothermophilus [TaxId:1422] [117526] (2 PDB entries) Uniprot P21873 |
![]() | automated matches [190098] (3 species) not a true protein |
![]() | Species Bacillus stearothermophilus [TaxId:1422] [188729] (3 PDB entries) |
![]() | Species Human (Homo sapiens) [TaxId:9606] [186820] (5 PDB entries) |
![]() | Species Pseudomonas putida [TaxId:303] [186989] (1 PDB entry) |
Timeline for Family c.36.1.11: Branched-chain alpha-keto acid dehydrogenase PP module: