Lineage for Family c.36.1.11: Branched-chain alpha-keto acid dehydrogenase PP module

  1. Root: SCOP 1.75
  2. 814173Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 828800Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. 828801Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (8 families) (S)
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
  5. 829269Family c.36.1.11: Branched-chain alpha-keto acid dehydrogenase PP module [88766] (4 proteins)
    parent family to TK and PFOR
    heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module

Proteins:

  1. 8292702-oxoisovalerate dehydrogenase (E1B), PP module [88769] (1 species)
    chain A is alpha-subunit and chain B is beta-subunit
  2. 829277Branched-chain alpha-keto acid dehydrogenase, PP module [88767] (2 species)
    1. 829278Species Human (Homo sapiens) [TaxId:9606] [88768] (23 PDB entries)
      Uniprot P12694 52-445
    2. 829302Species Thermus thermophilus [TaxId:274] [102337] (4 PDB entries)
  3. 829311E1-beta subunit of pyruvate dehydrogenase (PP module) [89651] (1 species)
  4. 829317Pyruvate dehydrogenase E1-alpha, PdhA [117525] (1 species)

More info for Family c.36.1.11: Branched-chain alpha-keto acid dehydrogenase PP module

Timeline for Family c.36.1.11: Branched-chain alpha-keto acid dehydrogenase PP module: