SCOP 1.75: Protein: Pyruvate dehydrogenase E1 component, PP module

Lineage for Protein: Pyruvate dehydrogenase E1 component, PP module

Root: SCOP 1.75
Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (8 families)

there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules

Family c.36.1.10: TK-like PP module [88760] (2 proteins)
different order of the modules, PP module is N-terminal, Pyr module is next to it followed by a Rossmann-like domain
Protein Pyruvate dehydrogenase E1 component, PP module [88764] (1 species)
E1A and E1B fused together in a single-chain protein

Species:

Escherichia coli [TaxId:562] [88765] (8 PDB entries)
1. Domains for 1l8a:
  1. Domain d1l8aa1: 1l8a A:56-470 [73677]
    Other proteins in same PDB: d1l8aa2, d1l8aa3, d1l8ab2, d1l8ab3
  2. Domain d1l8ab1: 1l8a B:56-470 [73680]
    Other proteins in same PDB: d1l8aa2, d1l8aa3, d1l8ab2, d1l8ab3
    complexed with mg, tdp
2. Domains for 1rp7:
  1. Domain d1rp7a2: 1rp7 A:56-470 [97703]
    Other proteins in same PDB: d1rp7a1, d1rp7a3, d1rp7b1, d1rp7b3
  2. Domain d1rp7b2: 1rp7 B:56-470 [97706]
    Other proteins in same PDB: d1rp7a1, d1rp7a3, d1rp7b1, d1rp7b3
    complexed with mg, tzd
3. Domains for 2g25:
  1. Domain d2g25a2: 2g25 A:56-470 [134524]
    Other proteins in same PDB: d2g25a1, d2g25a3, d2g25b1, d2g25b3
    automatically matched to d1l8aa1
    complexed with mg, po4, tdk
  2. Domain d2g25b2: 2g25 B:56-470 [134527]
    Other proteins in same PDB: d2g25a1, d2g25a3, d2g25b1, d2g25b3
    automatically matched to d1l8aa1
    complexed with mg, po4, tdk
4. Domains for 2g28:
  1. Domain d2g28a2: 2g28 A:56-470 [134530]
    Other proteins in same PDB: d2g28a1, d2g28a3, d2g28b1, d2g28b3
    automatically matched to d1l8aa1
    complexed with mg, tdk
  2. Domain d2g28b2: 2g28 B:56-470 [134533]
    Other proteins in same PDB: d2g28a1, d2g28a3, d2g28b1, d2g28b3
    automatically matched to d1l8aa1
    complexed with mg, tdk
5. Domains for 2g67:
  1. Domain d2g67a2: 2g67 A:56-470 [134696]
    Other proteins in same PDB: d2g67a1, d2g67a3, d2g67b1, d2g67b3
    automatically matched to d1l8aa1
  2. Domain d2g67b2: 2g67 B:56-470 [134699]
    Other proteins in same PDB: d2g67a1, d2g67a3, d2g67b1, d2g67b3
    automatically matched to d1l8aa1
6. Domains for 2iea:
  1. Domain d2ieaa2: 2iea A:56-470 [137295]
    Other proteins in same PDB: d2ieaa1, d2ieaa3, d2ieab1, d2ieab3
    automatically matched to d1l8aa1
    complexed with mg, tdp
  2. Domain d2ieab2: 2iea B:56-470 [137298]
    Other proteins in same PDB: d2ieaa1, d2ieaa3, d2ieab1, d2ieab3
    automatically matched to d1l8aa1
    complexed with mg, tdp
7. Domains for 2qta:
  1. Domain d2qtaa2: 2qta A:56-470 [151334]
    Other proteins in same PDB: d2qtaa1, d2qtaa3, d2qtab1, d2qtab3
    automatically matched to d1l8aa1
    complexed with mg, tdp; mutant
  2. Domain d2qtab2: 2qta B:56-470 [151337]
    Other proteins in same PDB: d2qtaa1, d2qtaa3, d2qtab1, d2qtab3
    automatically matched to d1l8aa1
    complexed with mg, tdp; mutant
8. Domains for 2qtc:
  1. Domain d2qtca2: 2qtc A:56-470 [151344]
    Other proteins in same PDB: d2qtca1, d2qtca3, d2qtcb1, d2qtcb3
    automatically matched to d1l8aa1
    complexed with mg, tdk; mutant
  2. Domain d2qtcb2: 2qtc B:56-470 [151347]
    Other proteins in same PDB: d2qtca1, d2qtca3, d2qtcb1, d2qtcb3
    automatically matched to d1l8aa1
    complexed with mg, tdk; mutant

More info for Protein Pyruvate dehydrogenase E1 component, PP module from c.36.1.10: TK-like PP module

Timeline for Protein Pyruvate dehydrogenase E1 component, PP module from c.36.1.10: TK-like PP module:

Protein Pyruvate dehydrogenase E1 component, PP module from c.36.1.10: TK-like PP module first appeared in SCOP 1.65
Protein Pyruvate dehydrogenase E1 component, PP module from c.36.1.10: TK-like PP module appears in SCOP 1.73
Protein Pyruvate dehydrogenase E1 component, PP module from c.36.1.10: TK-like PP module appears in SCOPe 2.01
Protein Pyruvate dehydrogenase E1 component, PP module from c.36.1.10: TK-like PP module appears in the current release, SCOPe 2.08