Lineage for Family c.36.1.10: TK-like PP module

  1. Root: SCOP 1.75
  2. 814173Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 828800Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. 828801Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (8 families) (S)
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
  5. 829218Family c.36.1.10: TK-like PP module [88760] (2 proteins)
    different order of the modules, PP module is N-terminal, Pyr module is next to it followed by a Rossmann-like domain

Proteins:

  1. 829219Pyruvate dehydrogenase E1 component, PP module [88764] (1 species)
    E1A and E1B fused together in a single-chain protein
  2. 829237Transketolase (TK), PP module [88761] (4 species)
    1. 829238Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [88762] (7 PDB entries)
    2. 829253Species Escherichia coli [TaxId:562] [89656] (4 PDB entries)
    3. 829262Species Leishmania mexicana mexicana [TaxId:44270] [117524] (1 PDB entry)
      Uniprot Q8MPM3
    4. 829265Species Maize (Zea mays) [TaxId:4577] [88763] (1 PDB entry)

More info for Family c.36.1.10: TK-like PP module

Timeline for Family c.36.1.10: TK-like PP module: