Class c: Alpha and beta proteins (a/b) [51349] (147 folds) |
Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily) 3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465 |
Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (8 families) there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules |
Family c.36.1.10: TK-like PP module [88760] (2 proteins) different order of the modules, PP module is N-terminal, Pyr module is next to it followed by a Rossmann-like domain |
Pyruvate dehydrogenase E1 component, PP module [88764] (1 species) E1A and E1B fused together in a single-chain protein |
Species Escherichia coli [TaxId:562] [88765] (8 PDB entries) |
Transketolase (TK), PP module [88761] (4 species) |
Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [88762] (7 PDB entries) |
Species Escherichia coli [TaxId:562] [89656] (4 PDB entries) |
Species Leishmania mexicana mexicana [TaxId:44270] [117524] (1 PDB entry) Uniprot Q8MPM3 |
Species Maize (Zea mays) [TaxId:4577] [88763] (1 PDB entry) |
Timeline for Family c.36.1.10: TK-like PP module: