Lineage for Family c.36.1.10: TK-like PP module

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2108258Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. 2108259Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families) (S)
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
  5. 2108664Family c.36.1.10: TK-like PP module [88760] (3 protein domains)
    different order of the modules, PP module is N-terminal, Pyr module is next to it followed by a Rossmann-like domain

Protein Domains:

  1. 2108665Pyruvate dehydrogenase E1 component, PP module [88764] (1 species)
    E1A and E1B fused together in a single-chain protein
  2. 2108683Transketolase (TK), PP module [88761] (4 species)
    1. 2108684Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [88762] (7 PDB entries)
    2. 2108699Species Escherichia coli [TaxId:562] [89656] (4 PDB entries)
    3. 2108708Species Leishmania mexicana mexicana [TaxId:44270] [117524] (1 PDB entry)
      Uniprot Q8MPM3
    4. 2108711Species Maize (Zea mays) [TaxId:4577] [88763] (1 PDB entry)
  3. 2108715automated matches [254698] (1 species)
    not a true protein

More info for Family c.36.1.10: TK-like PP module

Timeline for Family c.36.1.10: TK-like PP module: