SCOPe 2.08: Protein: Acetohydroxyacid synthase catalytic subunit

Lineage for Protein: Acetohydroxyacid synthase catalytic subunit

Root: SCOPe 2.08
Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families)

(S)

there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules

Family c.36.1.9: Pyruvate oxidase and decarboxylase PP module [88749] (8 proteins)
the N-terminal, Pyr module is separated from the C-terminal, PP module by an alpa/beta domain of Rossmann-like topology

Protein Acetohydroxyacid synthase catalytic subunit [88758] (3 species)

Species:

Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [88759] (8 PDB entries)
Uniprot P07342 84-687
1. Domains for 1jsc:
  1. Domain d1jsca3: 1jsc A:461-648 [67226]
    Other proteins in same PDB: d1jsca1, d1jsca2, d1jscb1, d1jscb2
    complexed with 2hp, fad, k, mg, tpp
  2. Domain d1jscb3: 1jsc B:464-649 [67229]
    Other proteins in same PDB: d1jsca1, d1jsca2, d1jscb1, d1jscb2
    complexed with 2hp, fad, k, mg, tpp
2. Domains for 1n0h:
  1. Domain d1n0ha3: 1n0h A:461-687 [79736]
    Other proteins in same PDB: d1n0ha1, d1n0ha2, d1n0hb1, d1n0hb2
    complexed with ayd, cie, dtt, fad, k, mg, tpp
  2. Domain d1n0hb3: 1n0h B:461-687 [79739]
    Other proteins in same PDB: d1n0ha1, d1n0ha2, d1n0hb1, d1n0hb2
    complexed with ayd, cie, dtt, fad, k, mg, tpp
3. Domains for 1t9a:
  1. Domain d1t9aa3: 1t9a A:461-687 [112330]
    Other proteins in same PDB: d1t9aa1, d1t9aa2, d1t9ab1, d1t9ab2
    complexed with 1tb, fad, k, mg, p23, yf3, yf4
  2. Domain d1t9ab3: 1t9a B:461-687 [112333]
    Other proteins in same PDB: d1t9aa1, d1t9aa2, d1t9ab1, d1t9ab2
    complexed with 1tb, fad, k, mg, p23, yf3, yf4
4. Domains for 1t9b:
  1. Domain d1t9ba3: 1t9b A:461-687 [112336]
    Other proteins in same PDB: d1t9ba1, d1t9ba2, d1t9bb1, d1t9bb2
    complexed with 1cs, fad, k, mg, nsp, p22, p25, yf3
  2. Domain d1t9bb3: 1t9b B:461-687 [112339]
    Other proteins in same PDB: d1t9ba1, d1t9ba2, d1t9bb1, d1t9bb2
    complexed with 1cs, fad, k, mg, nsp, p22, p25, yf3
5. Domains for 1t9c:
  1. Domain d1t9ca3: 1t9c A:461-687 [112342]
    Other proteins in same PDB: d1t9ca1, d1t9ca2, d1t9cb1, d1t9cb2
    complexed with 1sm, fad, k, mg, p22, p23
  2. Domain d1t9cb3: 1t9c B:461-687 [112345]
    Other proteins in same PDB: d1t9ca1, d1t9ca2, d1t9cb1, d1t9cb2
    complexed with 1sm, fad, k, mg, p22, p23
6. Domains for 1t9d:
  1. Domain d1t9da3: 1t9d A:461-687 [112348]
    Other proteins in same PDB: d1t9da1, d1t9da2, d1t9db1, d1t9db2, d1t9dc1, d1t9dc2, d1t9dd1, d1t9dd2
    complexed with 1mm, fad, k, mg, p22, p25, pyd
  2. Domain d1t9db3: 1t9d B:461-687 [112351]
    Other proteins in same PDB: d1t9da1, d1t9da2, d1t9db1, d1t9db2, d1t9dc1, d1t9dc2, d1t9dd1, d1t9dd2
    complexed with 1mm, fad, k, mg, p22, p25, pyd
  3. Domain d1t9dc3: 1t9d C:461-687 [112354]
    Other proteins in same PDB: d1t9da1, d1t9da2, d1t9db1, d1t9db2, d1t9dc1, d1t9dc2, d1t9dd1, d1t9dd2
    complexed with 1mm, fad, k, mg, p22, p25, pyd
  4. Domain d1t9dd3: 1t9d D:461-687 [112357]
    Other proteins in same PDB: d1t9da1, d1t9da2, d1t9db1, d1t9db2, d1t9dc1, d1t9dc2, d1t9dd1, d1t9dd2
    complexed with 1mm, fad, k, mg, p22, p25, pyd
7. Domains for 6bd3:
  1. Domain d6bd3a3: 6bd3 A:461-648 [344489]
    Other proteins in same PDB: d6bd3a1, d6bd3a2, d6bd3b1, d6bd3b2
    complexed with act, co2, fad, htl, k, mg, oxy, po4, tpp
  2. Domain d6bd3b3: 6bd3 B:461-649 [344490]
    Other proteins in same PDB: d6bd3a1, d6bd3a2, d6bd3b1, d6bd3b2
    complexed with act, co2, fad, htl, k, mg, oxy, po4, tpp
8. Domains for 6bd9:
  1. Domain d6bd9a3: 6bd9 A:461-648 [344491]
    Other proteins in same PDB: d6bd9a1, d6bd9a2, d6bd9b1, d6bd9b2
    complexed with fad, k, mg, oxy, po4, pyr, tpp
  2. Domain d6bd9b3: 6bd9 B:461-646 [344492]
    Other proteins in same PDB: d6bd9a1, d6bd9a2, d6bd9b1, d6bd9b2
    complexed with fad, k, mg, oxy, po4, pyr, tpp

Baker's yeast (Saccharomyces cerevisiae) [TaxId:559292] [314110] (3 PDB entries)

Domains for 5fem:
1. Domain d5fema3: 5fem A:461-687 [314123]
  Other proteins in same PDB: d5fema1, d5fema2, d5femb1, d5femb2
  automated match to d1n0ha3
  complexed with 60g, fad, mg, tpp
2. Domain d5femb3: 5fem B:461-687 [314111]
  Other proteins in same PDB: d5fema1, d5fema2, d5femb1, d5femb2
  automated match to d1n0ha3
  complexed with 60g, fad, mg, tpp
Domains for 5ims:
1. Domain d5imsa3: 5ims A:461-647 [344276]
  Other proteins in same PDB: d5imsa1, d5imsa2, d5imsb1, d5imsb2
  complexed with act, fad, k, mg, oxy, po4, tpp
2. Domain d5imsb3: 5ims B:461-647 [344277]
  Other proteins in same PDB: d5imsa1, d5imsa2, d5imsb1, d5imsb2
  complexed with act, fad, k, mg, oxy, po4, tpp

Domains for 5wkc:

Domain d5wkca3: 5wkc A:461-687 [348198]
Other proteins in same PDB: d5wkca1, d5wkca2, d5wkcb1, d5wkcb2, d5wkcd1, d5wkcd2, d5wkce1, d5wkce2
automated match to d1n0ha3
complexed with auj, f50, fad, mg, pxd, tp9

Domain d5wkcb3: 5wkc B:461-687 [348348]
Other proteins in same PDB: d5wkca1, d5wkca2, d5wkcb1, d5wkcb2, d5wkcd1, d5wkcd2, d5wkce1, d5wkce2
automated match to d1n0ha3
complexed with auj, f50, fad, mg, pxd, tp9

Domain d5wkcd3: 5wkc D:461-687 [348218]
Other proteins in same PDB: d5wkca1, d5wkca2, d5wkcb1, d5wkcb2, d5wkcd1, d5wkcd2, d5wkce1, d5wkce2
automated match to d1n0ha3
complexed with auj, f50, fad, mg, pxd, tp9

Domain d5wkce3: 5wkc E:461-687 [348304]
Other proteins in same PDB: d5wkca1, d5wkca2, d5wkcb1, d5wkcb2, d5wkcd1, d5wkcd2, d5wkce1, d5wkce2
automated match to d1n0ha3
complexed with auj, f50, fad, mg, pxd, tp9

Thale cress (Arabidopsis thaliana), chloroplast [TaxId:3702] [142208] (12 PDB entries)
Uniprot P17597 460-667
1. Domain for 1ybh:
  - Domain d1ybha3: 1ybh A:460-667 [122893]
    Other proteins in same PDB: d1ybha1, d1ybha2
    complexed with cie, fad, mg, nhe, p22
2. Domain for 1yhy:
  - Domain d1yhya3: 1yhy A:460-667 [123217]
    Other proteins in same PDB: d1yhya1, d1yhya2
    automated match to d1ybha3
    complexed with 1mm, fad, mg, nhe, p22
3. Domain for 1yhz:
  - Domain d1yhza3: 1yhz A:460-667 [123220]
    Other proteins in same PDB: d1yhza1, d1yhza2
    automated match to d1ybha3
    complexed with 1cs, fad, mg, nhe, p22
4. Domain for 1yi0:
  - Domain d1yi0a3: 1yi0 A:460-667 [123223]
    Other proteins in same PDB: d1yi0a1, d1yi0a2
    automated match to d1ybha3
    complexed with 1sm, fad, mg, nhe, p22
5. Domain for 1yi1:
  - Domain d1yi1a3: 1yi1 A:460-667 [123226]
    Other proteins in same PDB: d1yi1a1, d1yi1a2
    automated match to d1ybha3
    complexed with 1tb, fad, mg, nhe, p22
6. Domain for 1z8n:
  - Domain d1z8na3: 1z8n A:460-667 [124721]
    Other proteins in same PDB: d1z8na1, d1z8na2
    automated match to d1ybha3
    complexed with 1iq, fad, mg, nhe, tpp
7. Domain for 5k2o:
  - Domain d5k2oa3: 5k2o A:460-667 [329454]
    Other proteins in same PDB: d5k2oa1, d5k2oa2, d5k2oa4
    automated match to d1ybha3
    complexed with 6qk, cit, fad, mg, tp9
8. Domain for 5k3s:
  - Domain d5k3sa3: 5k3s A:460-667 [329460]
    Other proteins in same PDB: d5k3sa1, d5k3sa2, d5k3sa4
    automated match to d1ybha3
    complexed with 6ql, fad, mg, tp9
9. Domain for 5k6q:
  - Domain d5k6qa3: 5k6q A:460-667 [334842]
    Other proteins in same PDB: d5k6qa1, d5k6qa2
    automated match to d1ybha3
    complexed with fad, mg, nhe, tdm
10. Domain for 5k6r:
  - Domain d5k6ra3: 5k6r A:460-667 [329464]
    Other proteins in same PDB: d5k6ra1, d5k6ra2
    automated match to d1ybha3
    complexed with 6r5, fad, k, mg, nhe, tzd
11. Domain for 5k6t:
  - Domain d5k6ta3: 5k6t A:460-667 [329469]
    Other proteins in same PDB: d5k6ta1, d5k6ta2
    automated match to d1ybha3
    complexed with 6r4, fad, k, mg, nhe, tzd
12. Domain for 5wj1:
  - Domain d5wj1a3: 5wj1 A:460-667 [348143]
    Other proteins in same PDB: d5wj1a1, d5wj1a2
    automated match to d1ybha3
    complexed with f50, fad, k, mg, pxd, tp9

More info for Protein Acetohydroxyacid synthase catalytic subunit from c.36.1.9: Pyruvate oxidase and decarboxylase PP module

Timeline for Protein Acetohydroxyacid synthase catalytic subunit from c.36.1.9: Pyruvate oxidase and decarboxylase PP module:

Protein Acetohydroxyacid synthase catalytic subunit from c.36.1.9: Pyruvate oxidase and decarboxylase PP module first appeared in SCOP 1.65
Protein Acetohydroxyacid synthase catalytic subunit from c.36.1.9: Pyruvate oxidase and decarboxylase PP module appears in SCOPe 2.07