SCOPe 2.02: Protein: Pyruvate oxidase

Lineage for Protein: Pyruvate oxidase

Root: SCOPe 2.02
Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (8 families)

there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules

Family c.36.1.9: Pyruvate oxidase and decarboxylase PP module [88749] (8 proteins)
the N-terminal, Pyr module is separated from the C-terminal, PP module by an alpa/beta domain of Rossmann-like topology

Protein Pyruvate oxidase [88754] (2 species)

Species:

Aerococcus viridans [TaxId:1377] [142207] (4 PDB entries)
1. Domain for 1v5e:
  - Domain d1v5ea3: 1v5e A:364-592 [119846]
    Other proteins in same PDB: d1v5ea1, d1v5ea2
    complexed with fad, so4
2. Domain for 1v5f:
  - Domain d1v5fa3: 1v5f A:364-592 [119849]
    Other proteins in same PDB: d1v5fa1, d1v5fa2
    automatically matched to 1V5E A:364-592
    complexed with fad, mg, so4, tpp
3. Domain for 1v5g:
  - Domain d1v5ga3: 1v5g A:364-592 [119852]
    Other proteins in same PDB: d1v5ga1, d1v5ga2
    automatically matched to 1V5E A:364-592
    complexed with fad, htl, mg
4. Domain for 2dji:
  - Domain d2djia3: 2dji A:364-592 [131546]
    Other proteins in same PDB: d2djia1, d2djia2
    automatically matched to 1V5E A:364-592
    complexed with fad, so4
Lactobacillus plantarum [TaxId:1590] [88755] (7 PDB entries)
1. Domains for 1pow:
  1. Domain d1powa3: 1pow A:366-593 [31798]
    Other proteins in same PDB: d1powa1, d1powa2, d1powb1, d1powb2
    complexed with fad, mg, tpp; mutant
  2. Domain d1powb3: 1pow B:366-593 [31800]
    Other proteins in same PDB: d1powa1, d1powa2, d1powb1, d1powb2
    complexed with fad, mg, tpp; mutant
2. Domains for 1pox:
  1. Domain d1poxa3: 1pox A:366-593 [31794]
    Other proteins in same PDB: d1poxa1, d1poxa2, d1poxb1, d1poxb2
    complexed with fad, gol, mg, na, tpp; mutant
  2. Domain d1poxb3: 1pox B:366-593 [31796]
    Other proteins in same PDB: d1poxa1, d1poxa2, d1poxb1, d1poxb2
    complexed with fad, gol, mg, na, tpp; mutant
3. Domains for 2ez4:
  1. Domain d2ez4a3: 2ez4 A:366-593 [132612]
    Other proteins in same PDB: d2ez4a1, d2ez4a2, d2ez4b1, d2ez4b2
    automatically matched to d1powa3
    complexed with fad, mg, na, po4, tpp
  2. Domain d2ez4b3: 2ez4 B:366-593 [132615]
    Other proteins in same PDB: d2ez4a1, d2ez4a2, d2ez4b1, d2ez4b2
    automatically matched to d1powa3
    complexed with fad, mg, na, po4, tpp
4. Domains for 2ez8:
  1. Domain d2ez8a3: 2ez8 A:366-593 [132623]
    Other proteins in same PDB: d2ez8a1, d2ez8a2, d2ez8b1, d2ez8b2
    automatically matched to d1powa3
    complexed with fad, mg, na, pyr, tdl
  2. Domain d2ez8b3: 2ez8 B:366-593 [132626]
    Other proteins in same PDB: d2ez8a1, d2ez8a2, d2ez8b1, d2ez8b2
    automatically matched to d1powa3
    complexed with fad, mg, na, pyr, tdl
5. Domains for 2ez9:
  1. Domain d2ez9a3: 2ez9 A:366-593 [132629]
    Other proteins in same PDB: d2ez9a1, d2ez9a2, d2ez9b1, d2ez9b2
    automatically matched to d1powa3
    complexed with fad, mg, na, tdk
  2. Domain d2ez9b3: 2ez9 B:366-593 [132632]
    Other proteins in same PDB: d2ez9a1, d2ez9a2, d2ez9b1, d2ez9b2
    automatically matched to d1powa3
    complexed with fad, mg, na, tdk
6. Domains for 2ezt:
  1. Domain d2ezta3: 2ezt A:366-593 [132635]
    Other proteins in same PDB: d2ezta1, d2ezta2, d2eztb1, d2eztb2
    automatically matched to d1powa3
    complexed with fad, mg, na, po4, pyr, tdm
  2. Domain d2eztb3: 2ezt B:366-593 [132638]
    Other proteins in same PDB: d2ezta1, d2ezta2, d2eztb1, d2eztb2
    automatically matched to d1powa3
    complexed with fad, mg, na, po4, pyr, tdm
7. Domains for 2ezu:
  1. Domain d2ezua3: 2ezu A:366-593 [132641]
    Other proteins in same PDB: d2ezua1, d2ezua2, d2ezub1, d2ezub2
    automatically matched to d1powa3
    complexed with fad, htl, mg, na, pyr
  2. Domain d2ezub3: 2ezu B:366-593 [132644]
    Other proteins in same PDB: d2ezua1, d2ezua2, d2ezub1, d2ezub2
    automatically matched to d1powa3
    complexed with fad, htl, mg, na, pyr

More info for Protein Pyruvate oxidase from c.36.1.9: Pyruvate oxidase and decarboxylase PP module

Timeline for Protein Pyruvate oxidase from c.36.1.9: Pyruvate oxidase and decarboxylase PP module:

Protein Pyruvate oxidase from c.36.1.9: Pyruvate oxidase and decarboxylase PP module first appeared in SCOP 1.65
Protein Pyruvate oxidase from c.36.1.9: Pyruvate oxidase and decarboxylase PP module appears in SCOPe 2.01
Protein Pyruvate oxidase from c.36.1.9: Pyruvate oxidase and decarboxylase PP module appears in SCOPe 2.03
Protein Pyruvate oxidase from c.36.1.9: Pyruvate oxidase and decarboxylase PP module appears in the current release, SCOPe 2.08