SCOP 1.73: Protein: Pyruvate decarboxylase

Lineage for Protein: Pyruvate decarboxylase

Root: SCOP 1.73
Class c: Alpha and beta proteins (a/b) [51349] (141 folds)
Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (8 families)

there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules

Family c.36.1.9: Pyruvate oxidase and decarboxylase PP module [88749] (8 proteins)
the N-terminal, Pyr module is separated from the C-terminal, PP module by an alpa/beta domain of Rossmann-like topology

Protein Pyruvate decarboxylase [88750] (3 species)

Species:

Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [88752] (2 PDB entries)
1. Domains for 1pvd:
  1. Domain d1pvda3: 1pvd A:361-556 [31778]
    Other proteins in same PDB: d1pvda1, d1pvda2, d1pvdb1, d1pvdb2
  2. Domain d1pvdb3: 1pvd B:361-556 [31780]
    Other proteins in same PDB: d1pvda1, d1pvda2, d1pvdb1, d1pvdb2
    complexed with mg, tpp
2. Domains for 1qpb:
  1. Domain d1qpba3: 1qpb A:361-556 [31782]
    Other proteins in same PDB: d1qpba1, d1qpba2, d1qpbb1, d1qpbb2
  2. Domain d1qpbb3: 1qpb B:361-556 [31784]
    Other proteins in same PDB: d1qpba1, d1qpba2, d1qpbb1, d1qpbb2
Brewer's yeast (Saccharomyces), uvarum strain [TaxId:230603] [88751] (1 PDB entry)
- Domains for 1pyd:
  1. Domain d1pyda3: 1pyd A:361-556 [31774]
    Other proteins in same PDB: d1pyda1, d1pyda2, d1pydb1, d1pydb2
  2. Domain d1pydb3: 1pyd B:361-556 [31776]
    Other proteins in same PDB: d1pyda1, d1pyda2, d1pydb1, d1pydb2
    complexed with mg, tdp
Zymomonas mobilis [TaxId:542] [88753] (1 PDB entry)
- Domains for 1zpd:
  1. Domain d1zpda3: 1zpd A:363-566 [31786]
    Other proteins in same PDB: d1zpda1, d1zpda2, d1zpdb1, d1zpdb2, d1zpde1, d1zpde2, d1zpdf1, d1zpdf2
  2. Domain d1zpdb3: 1zpd B:363-566 [31788]
    Other proteins in same PDB: d1zpda1, d1zpda2, d1zpdb1, d1zpdb2, d1zpde1, d1zpde2, d1zpdf1, d1zpdf2
  3. Domain d1zpde3: 1zpd E:363-566 [31790]
    Other proteins in same PDB: d1zpda1, d1zpda2, d1zpdb1, d1zpdb2, d1zpde1, d1zpde2, d1zpdf1, d1zpdf2
  4. Domain d1zpdf3: 1zpd F:363-566 [31792]
    Other proteins in same PDB: d1zpda1, d1zpda2, d1zpdb1, d1zpdb2, d1zpde1, d1zpde2, d1zpdf1, d1zpdf2
    complexed with cit, dpx, mg

More info for Protein Pyruvate decarboxylase from c.36.1.9: Pyruvate oxidase and decarboxylase PP module

Timeline for Protein Pyruvate decarboxylase from c.36.1.9: Pyruvate oxidase and decarboxylase PP module:

Protein Pyruvate decarboxylase from c.36.1.9: Pyruvate oxidase and decarboxylase PP module first appeared in SCOP 1.65
Protein Pyruvate decarboxylase from c.36.1.9: Pyruvate oxidase and decarboxylase PP module appears in SCOP 1.71
Protein Pyruvate decarboxylase from c.36.1.9: Pyruvate oxidase and decarboxylase PP module appears in SCOP 1.75
Protein Pyruvate decarboxylase from c.36.1.9: Pyruvate oxidase and decarboxylase PP module appears in the current release, SCOPe 2.08