Lineage for Protein: Pyruvate decarboxylase

  1. Root: SCOP 1.65
  2. 305035Class c: Alpha and beta proteins (a/b) [51349] (121 folds)
  3. 312976Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. 312977Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (8 families) (S)
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
  5. 313084Family c.36.1.9: Pyruvate oxidase and decarboxylase PP module [88749] (5 proteins)
    the N-terminal, Pyr module is separated from the C-terminal, PP module by an alpa/beta domain of Rossmann-like topology
  6. 313116Protein Pyruvate decarboxylase [88750] (3 species)

Species:

  1. 313117Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [88752] (2 PDB entries)
    1. Domains for 1pvd:
      1. 313118Domain d1pvda3: 1pvd A:361-556 [31778]
        Other proteins in same PDB: d1pvda1, d1pvda2, d1pvdb1, d1pvdb2
      2. 313119Domain d1pvdb3: 1pvd B:361-556 [31780]
        Other proteins in same PDB: d1pvda1, d1pvda2, d1pvdb1, d1pvdb2
        complexed with mg, tpp
    2. Domains for 1qpb:
      1. 313120Domain d1qpba3: 1qpb A:361-556 [31782]
        Other proteins in same PDB: d1qpba1, d1qpba2, d1qpbb1, d1qpbb2
      2. 313121Domain d1qpbb3: 1qpb B:361-556 [31784]
        Other proteins in same PDB: d1qpba1, d1qpba2, d1qpbb1, d1qpbb2
  2. 313122Brewer's yeast (Saccharomyces), uvarum strain [TaxId:230603] [88751] (1 PDB entry)
  3. 313125Zymomonas mobilis [TaxId:542] [88753] (1 PDB entry)

More info for Protein Pyruvate decarboxylase from c.36.1.9: Pyruvate oxidase and decarboxylase PP module

Timeline for Protein Pyruvate decarboxylase from c.36.1.9: Pyruvate oxidase and decarboxylase PP module: