Class c: Alpha and beta proteins (a/b) [51349] (148 folds) |
Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily) 3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465 |
Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families) there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules |
Family c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module [88741] (5 proteins) parent family to TK and PFOR heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module automatically mapped to Pfam PF02779 |
Protein Branched-chain alpha-keto acid dehydrogenase, Pyr module [88742] (2 species) |
Species Human (Homo sapiens) [TaxId:9606] [88743] (23 PDB entries) Uniprot P21953 52-392 |
Domain d1dtwb1: 1dtw B:17-204 [31828] Other proteins in same PDB: d1dtwa_, d1dtwb2 complexed with k, mg, tdp |
Domain d1olsb1: 1ols B:2-204 [93332] Other proteins in same PDB: d1olsa_, d1olsb2 complexed with gol, k, mn, tdp |
Domain d1olub1: 1olu B:2-204 [93336] Other proteins in same PDB: d1olua_, d1olub2 complexed with gol, k, mg, tdp |
Domain d1olxb1: 1olx B:2-204 [93339] Other proteins in same PDB: d1olxa_, d1olxb2 complexed with gol, k, mn, tdp |
Domain d1u5bb1: 1u5b B:14-204 [113035] Other proteins in same PDB: d1u5ba_, d1u5bb2 complexed with gol, k, mn, tdp |
Domain d1v11b1: 1v11 B:2-204 [108228] Other proteins in same PDB: d1v11a_, d1v11b2 complexed with ben, cl, gol, k, mn, tdp |
Domain d1v16b1: 1v16 B:2-204 [108241] Other proteins in same PDB: d1v16a_, d1v16b2 complexed with ben, cl, gol, k, mn, tdp |
Domain d1v1mb1: 1v1m B:2-204 [108262] Other proteins in same PDB: d1v1ma_, d1v1mb2 complexed with ben, cl, gol, k, mn, tdp |
Domain d1v1rb1: 1v1r B:2-204 [108273] Other proteins in same PDB: d1v1ra_, d1v1rb2 complexed with cl, gol, k, na, so4 |
Domain d1wcib1: 1wci B:2-204 [120891] Other proteins in same PDB: d1wcia_, d1wcib2 automated match to d1v16b1 complexed with cl, gol, k, mn, wwf |
Domain d1x7wb1: 1x7w B:14-204 [114939] Other proteins in same PDB: d1x7wa_, d1x7wb2 complexed with cl, gol, k, mn, tdp |
Domain d1x7xb1: 1x7x B:14-204 [114942] Other proteins in same PDB: d1x7xa_, d1x7xb2 complexed with cl, gol, k, mn, tdp |
Domain d1x7yb1: 1x7y B:14-204 [114945] Other proteins in same PDB: d1x7ya_, d1x7yb2 complexed with cl, gol, k, mn, tdp |
Domain d1x7zb1: 1x7z B:14-204 [114948] Other proteins in same PDB: d1x7za_, d1x7zb2 complexed with cl, gol, k, mn, tdp |
Domain d1x80b1: 1x80 B:14-204 [114951] Other proteins in same PDB: d1x80a_, d1x80b2 complexed with cl, gol, k, mn, tdp |
Domain d2beub1: 2beu B:2-204 [128390] Other proteins in same PDB: d2beua_, d2beub2 automated match to d1v16b1 complexed with cl, gol, k, mn, so4, thv |
Domain d2bevb1: 2bev B:2-204 [128393] Other proteins in same PDB: d2beva_, d2bevb2 automated match to d1v16b1 complexed with cl, gol, k, mn, thy |
Domain d2bewb1: 2bew B:2-204 [128396] Other proteins in same PDB: d2bewa_, d2bewb2 automated match to d1v16b1 complexed with cl, gol, k, mn, thw |
Domain d2bfbb1: 2bfb B:14-204 [197786] Other proteins in same PDB: d2bfba1, d2bfbb2 automated match to d1x7yb1 complexed with cl, gol, k, mn, mrd, tdp |
Domain d2bfcb1: 2bfc B:2-204 [128417] Other proteins in same PDB: d2bfca1, d2bfcb2 automated match to d1v16b1 complexed with gol, k, mn, tzd |
Domain d2bfdb1: 2bfd B:2-204 [128419] Other proteins in same PDB: d2bfda1, d2bfdb2 automated match to d1v16b1 complexed with cl, gol, k, mn, mpd, tdp |
Domain d2bfeb1: 2bfe B:14-204 [197788] Other proteins in same PDB: d2bfea1, d2bfeb2 automated match to d1x7yb1 complexed with cl, gol, k, mn, mrd, tdp |
Domain d2bffb1: 2bff B:2-204 [128421] Other proteins in same PDB: d2bffa1, d2bffb2 automated match to d1v16b1 complexed with gol, k, mn, tzd |
Timeline for Species Human (Homo sapiens) [TaxId:9606] from c.36.1.7 Branched-chain alpha-keto acid dehydrogenase, Pyr module: