Lineage for Species: Human (Homo sapiens) [TaxId: 9606]
- Root: SCOPe 2.03
Class c: Alpha and beta proteins (a/b) [51349] (147 folds) 
Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families) 
there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
Family c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module [88741] (4 proteins)
parent family to TK and PFOR
heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module
automatically mapped to Pfam PF02779Protein Branched-chain alpha-keto acid dehydrogenase, Pyr module [88742] (2 species) Species Human (Homo sapiens) [TaxId:9606] [88743] (23 PDB entries)
Uniprot P21953 52-392
PDB entries in Species: Human (Homo sapiens) [TaxId: 9606]:
- Domain(s) for 1dtw:
Domain d1dtwb1: 1dtw B:17-204 [31828]
Other proteins in same PDB: d1dtwa_, d1dtwb2
complexed with k, mg, tdp
- Domain(s) for 1ols:
Domain d1olsb1: 1ols B:2-204 [93332]
Other proteins in same PDB: d1olsa_, d1olsb2
complexed with gol, k, mn, tdp
- Domain(s) for 1olu:
Domain d1olub1: 1olu B:2-204 [93336]
Other proteins in same PDB: d1olua_, d1olub2
complexed with gol, k, mg, tdp
- Domain(s) for 1olx:
Domain d1olxb1: 1olx B:2-204 [93339]
Other proteins in same PDB: d1olxa_, d1olxb2
complexed with gol, k, mn, tdp
- Domain(s) for 1u5b:
Domain d1u5bb1: 1u5b B:14-204 [113035]
Other proteins in same PDB: d1u5ba_, d1u5bb2
complexed with gol, k, mn, tdp
- Domain(s) for 1v11:
Domain d1v11b1: 1v11 B:2-204 [108228]
Other proteins in same PDB: d1v11a_, d1v11b2
complexed with ben, cl, gol, k, mn, tdp
- Domain(s) for 1v16:
Domain d1v16b1: 1v16 B:2-204 [108241]
Other proteins in same PDB: d1v16a_, d1v16b2
complexed with ben, cl, gol, k, mn, tdp
- Domain(s) for 1v1m:
Domain d1v1mb1: 1v1m B:2-204 [108262]
Other proteins in same PDB: d1v1ma_, d1v1mb2
complexed with ben, cl, gol, k, mn, tdp
- Domain(s) for 1v1r:
Domain d1v1rb1: 1v1r B:2-204 [108273]
Other proteins in same PDB: d1v1ra_, d1v1rb2
complexed with cl, gol, k, na, so4
- Domain(s) for 1wci:
Domain d1wcib1: 1wci B:2-204 [120891]
Other proteins in same PDB: d1wcia_, d1wcib2
automated match to d1v16b1
complexed with cl, gol, k, mn, wwf
- Domain(s) for 1x7w:
Domain d1x7wb1: 1x7w B:14-204 [114939]
Other proteins in same PDB: d1x7wa_, d1x7wb2
complexed with cl, gol, k, mn, tdp
- Domain(s) for 1x7x:
Domain d1x7xb1: 1x7x B:14-204 [114942]
Other proteins in same PDB: d1x7xa_, d1x7xb2
complexed with cl, gol, k, mn, tdp
- Domain(s) for 1x7y:
Domain d1x7yb1: 1x7y B:14-204 [114945]
Other proteins in same PDB: d1x7ya_, d1x7yb2
complexed with cl, gol, k, mn, tdp
- Domain(s) for 1x7z:
Domain d1x7zb1: 1x7z B:14-204 [114948]
Other proteins in same PDB: d1x7za_, d1x7zb2
complexed with cl, gol, k, mn, tdp
- Domain(s) for 1x80:
Domain d1x80b1: 1x80 B:14-204 [114951]
Other proteins in same PDB: d1x80a_, d1x80b2
complexed with cl, gol, k, mn, tdp
- Domain(s) for 2beu:
Domain d2beub1: 2beu B:2-204 [128390]
Other proteins in same PDB: d2beua_, d2beub2
automated match to d1v16b1
complexed with cl, gol, k, mn, so4, thv
- Domain(s) for 2bev:
Domain d2bevb1: 2bev B:2-204 [128393]
Other proteins in same PDB: d2beva_, d2bevb2
automated match to d1v16b1
complexed with cl, gol, k, mn, thy
- Domain(s) for 2bew:
Domain d2bewb1: 2bew B:2-204 [128396]
Other proteins in same PDB: d2bewa_, d2bewb2
automated match to d1v16b1
complexed with cl, gol, k, mn, thw
- Domain(s) for 2bfb:
Domain d2bfbb1: 2bfb B:14-204 [197786]
Other proteins in same PDB: d2bfba1, d2bfbb2
automated match to d1x7yb1
complexed with cl, gol, k, mn, mrd, tdp
- Domain(s) for 2bfc:
Domain d2bfcb1: 2bfc B:2-204 [128417]
Other proteins in same PDB: d2bfca1, d2bfcb2
automated match to d1v16b1
complexed with gol, k, mn, tzd
- Domain(s) for 2bfd:
Domain d2bfdb1: 2bfd B:2-204 [128419]
Other proteins in same PDB: d2bfda1, d2bfdb2
automated match to d1v16b1
complexed with cl, gol, k, mn, mpd, tdp
- Domain(s) for 2bfe:
Domain d2bfeb1: 2bfe B:14-204 [197788]
Other proteins in same PDB: d2bfea1, d2bfeb2
automated match to d1x7yb1
complexed with cl, gol, k, mn, mrd, tdp
- Domain(s) for 2bff:
Domain d2bffb1: 2bff B:2-204 [128421]
Other proteins in same PDB: d2bffa1, d2bffb2
automated match to d1v16b1
complexed with gol, k, mn, tzd
More info for Species Human (Homo sapiens) [TaxId:9606] from c.36.1.7 Branched-chain alpha-keto acid dehydrogenase, Pyr module
Timeline for Species Human (Homo sapiens) [TaxId:9606] from c.36.1.7 Branched-chain alpha-keto acid dehydrogenase, Pyr module:
- Species Human (Homo sapiens) [TaxId:9606] from c.36.1.7 Branched-chain alpha-keto acid dehydrogenase, Pyr module first appeared in SCOP 1.65
- Species Human (Homo sapiens) [TaxId:9606] from c.36.1.7 Branched-chain alpha-keto acid dehydrogenase, Pyr module appears in SCOPe 2.02
- Species Human (Homo sapiens) [TaxId:9606] from c.36.1.7 Branched-chain alpha-keto acid dehydrogenase, Pyr module appears in SCOPe 2.04
- Species Human (Homo sapiens) [TaxId:9606] from c.36.1.7 Branched-chain alpha-keto acid dehydrogenase, Pyr module appears in the current release, SCOPe 2.08