Lineage for Species: Human (Homo sapiens)
- Root: SCOP 1.67
Class c: Alpha and beta proteins (a/b) [51349] (130 folds) 
Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (8 families) 
there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
Family c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module [88741] (3 proteins)
parent family to TK and PFOR
heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr moduleProtein Branched-chain alpha-keto acid dehydrogenase, Pyr module [88742] (2 species) Species Human (Homo sapiens) [TaxId:9606] [88743] (4 PDB entries)
PDB entries in Species: Human (Homo sapiens):
- Domain(s) for 1dtw:
Domain d1dtwb1: 1dtw B:17-204 [31828]
Other proteins in same PDB: d1dtwa_, d1dtwb2
complexed with k, mg, tdp
- Domain(s) for 1ols:
Domain d1olsb1: 1ols B:2-204 [93332]
Other proteins in same PDB: d1olsa_, d1olsb2
complexed with gol, k, mn, tdp
- Domain(s) for 1olu:
Domain d1olub1: 1olu B:2-204 [93336]
Other proteins in same PDB: d1olua_, d1olub2
complexed with gol, k, mg, tdp; mutant
- Domain(s) for 1olx:
Domain d1olxb1: 1olx B:2-204 [93339]
Other proteins in same PDB: d1olxa_, d1olxb2
complexed with gol, k, mn, tdp; mutant
More info for Species Human (Homo sapiens) [TaxId:9606] from c.36.1.7 Branched-chain alpha-keto acid dehydrogenase, Pyr module
Timeline for Species Human (Homo sapiens) [TaxId:9606] from c.36.1.7 Branched-chain alpha-keto acid dehydrogenase, Pyr module:
- Species Human (Homo sapiens) [TaxId:9606] from c.36.1.7 Branched-chain alpha-keto acid dehydrogenase, Pyr module first appeared in SCOP 1.65
- Species Human (Homo sapiens) [TaxId:9606] from c.36.1.7 Branched-chain alpha-keto acid dehydrogenase, Pyr module appears in SCOP 1.69
- Species Human (Homo sapiens) [TaxId:9606] from c.36.1.7 Branched-chain alpha-keto acid dehydrogenase, Pyr module appears in the current release, SCOPe 2.08