SCOP 1.73: Protein: Branched-chain alpha-keto acid dehydrogenase, Pyr module

Lineage for Protein: Branched-chain alpha-keto acid dehydrogenase, Pyr module

Root: SCOP 1.73
Class c: Alpha and beta proteins (a/b) [51349] (141 folds)
Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (8 families)

there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules

Family c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module [88741] (4 proteins)
parent family to TK and PFOR
heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module

Protein Branched-chain alpha-keto acid dehydrogenase, Pyr module [88742] (2 species)

Species:

Human (Homo sapiens) [TaxId:9606] [88743] (21 PDB entries)
1. Domain for 1dtw:
  - Domain d1dtwb1: 1dtw B:17-204 [31828]
    Other proteins in same PDB: d1dtwa_, d1dtwb2
    complexed with k, mg, tdp
2. Domain for 1ols:
  - Domain d1olsb1: 1ols B:2-204 [93332]
    Other proteins in same PDB: d1olsa_, d1olsb2
    complexed with gol, k, mn, tdp
3. Domain for 1olu:
  - Domain d1olub1: 1olu B:2-204 [93336]
    Other proteins in same PDB: d1olua_, d1olub2
    complexed with gol, k, mg, tdp; mutant
4. Domain for 1olx:
  - Domain d1olxb1: 1olx B:2-204 [93339]
    Other proteins in same PDB: d1olxa_, d1olxb2
    complexed with gol, k, mn, tdp; mutant
5. Domain for 1u5b:
  - Domain d1u5bb1: 1u5b B:14-204 [113035]
    Other proteins in same PDB: d1u5ba_, d1u5bb2
    complexed with gol, k, mn, tdp
6. Domain for 1v11:
  - Domain d1v11b1: 1v11 B:2-204 [108228]
    Other proteins in same PDB: d1v11a_, d1v11b2
    complexed with bdn, cl, gol, k, mn, tdp; mutant
7. Domain for 1v16:
  - Domain d1v16b1: 1v16 B:2-204 [108241]
    Other proteins in same PDB: d1v16a_, d1v16b2
    complexed with bdn, cl, gol, k, mn, tdp; mutant
8. Domain for 1v1m:
  - Domain d1v1mb1: 1v1m B:2-204 [108262]
    Other proteins in same PDB: d1v1ma_, d1v1mb2
    complexed with bdn, cl, gol, k, mn, tdp; mutant
9. Domain for 1v1r:
  - Domain d1v1rb1: 1v1r B:2-204 [108273]
    Other proteins in same PDB: d1v1ra_, d1v1rb2
    complexed with cl, gol, k, na, so4
10. Domain for 1wci:
  - Domain d1wcib1: 1wci B:2-204 [120891]
    Other proteins in same PDB: d1wcia1, d1wcib2
    automatically matched to d1olsb1
    complexed with cl, gol, k, mn, wwf
11. Domain for 1x7w:
  - Domain d1x7wb1: 1x7w B:14-204 [114939]
    Other proteins in same PDB: d1x7wa_, d1x7wb2
    complexed with cl, gol, k, mn, tdp; mutant
12. Domain for 1x7x:
  - Domain d1x7xb1: 1x7x B:14-204 [114942]
    Other proteins in same PDB: d1x7xa_, d1x7xb2
    complexed with cl, gol, k, mn, tdp; mutant
13. Domain for 1x7y:
  - Domain d1x7yb1: 1x7y B:14-204 [114945]
    Other proteins in same PDB: d1x7ya_, d1x7yb2
    complexed with cl, gol, k, mn, tdp; mutant
14. Domain for 1x7z:
  - Domain d1x7zb1: 1x7z B:14-204 [114948]
    Other proteins in same PDB: d1x7za_, d1x7zb2
    complexed with cl, gol, k, mn, tdp; mutant
15. Domain for 1x80:
  - Domain d1x80b1: 1x80 B:14-204 [114951]
    Other proteins in same PDB: d1x80a_, d1x80b2
    complexed with cl, gol, k, mn, tdp
16. Domain for 2beu:
  - Domain d2beub1: 2beu B:2-204 [128390]
    Other proteins in same PDB: d2beua1, d2beub2
    automatically matched to d1olsb1
    complexed with cl, gol, k, mn, so4, thv
17. Domain for 2bev:
  - Domain d2bevb1: 2bev B:2-204 [128393]
    Other proteins in same PDB: d2beva1, d2bevb2
    automatically matched to d1olsb1
    complexed with cl, gol, k, mn, thy
18. Domain for 2bew:
  - Domain d2bewb1: 2bew B:2-204 [128396]
    Other proteins in same PDB: d2bewa1, d2bewb2
    automatically matched to d1olsb1
    complexed with cl, gol, k, mn, thw
19. Domain for 2bfc:
  - Domain d2bfcb1: 2bfc B:2-204 [128417]
    Other proteins in same PDB: d2bfcb2
    automatically matched to d1olsb1
    complexed with gol, k, mn, tzd; mutant
20. Domain for 2bfd:
  - Domain d2bfdb1: 2bfd B:2-204 [128419]
    Other proteins in same PDB: d2bfdb2
    automatically matched to d1olsb1
    complexed with cl, gol, k, mn, mpd, tdp; mutant
21. Domain for 2bff:
  - Domain d2bffb1: 2bff B:2-204 [128421]
    Other proteins in same PDB: d2bffb2
    automatically matched to d1olsb1
    complexed with gol, k, mn, tzd
Thermus thermophilus [TaxId:274] [102332] (4 PDB entries)
1. Domains for 1um9:
  1. Domain d1um9b1: 1um9 B:2-187 [99582]
    Other proteins in same PDB: d1um9a_, d1um9b2, d1um9c_, d1um9d2
  2. Domain d1um9d1: 1um9 D:2-187 [99585]
    Other proteins in same PDB: d1um9a_, d1um9b2, d1um9c_, d1um9d2
    complexed with so4
2. Domains for 1umb:
  1. Domain d1umbb1: 1umb B:2-187 [99588]
    Other proteins in same PDB: d1umba_, d1umbb2, d1umbc_, d1umbd2
  2. Domain d1umbd1: 1umb D:2-187 [99591]
    Other proteins in same PDB: d1umba_, d1umbb2, d1umbc_, d1umbd2
    complexed with mg, tdp
3. Domains for 1umc:
  1. Domain d1umcb1: 1umc B:2-187 [99594]
    Other proteins in same PDB: d1umca_, d1umcb2, d1umcc_, d1umcd2
  2. Domain d1umcd1: 1umc D:2-187 [99597]
    Other proteins in same PDB: d1umca_, d1umcb2, d1umcc_, d1umcd2
    complexed with 4mv, mg, tdp
4. Domains for 1umd:
  1. Domain d1umdb1: 1umd B:2-187 [99600]
    Other proteins in same PDB: d1umda_, d1umdb2, d1umdc_, d1umdd2
  2. Domain d1umdd1: 1umd D:2-187 [99603]
    Other proteins in same PDB: d1umda_, d1umdb2, d1umdc_, d1umdd2
    complexed with coi, mg, tdp

More info for Protein Branched-chain alpha-keto acid dehydrogenase, Pyr module from c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module

Timeline for Protein Branched-chain alpha-keto acid dehydrogenase, Pyr module from c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module:

Protein Branched-chain alpha-keto acid dehydrogenase, Pyr module from c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module first appeared in SCOP 1.65
Protein Branched-chain alpha-keto acid dehydrogenase, Pyr module from c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module appears in SCOP 1.71
Protein Branched-chain alpha-keto acid dehydrogenase, Pyr module from c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module appears in SCOP 1.75
Protein Branched-chain alpha-keto acid dehydrogenase, Pyr module from c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module appears in the current release, SCOPe 2.08