Lineage for Protein: Branched-chain alpha-keto acid dehydrogenase, Pyr module

  1. Root: SCOP 1.69
  2. 473232Class c: Alpha and beta proteins (a/b) [51349] (136 folds)
  3. 483377Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. 483378Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (8 families) (S)
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
  5. 483487Family c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module [88741] (3 proteins)
    parent family to TK and PFOR
    heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module
  6. 483491Protein Branched-chain alpha-keto acid dehydrogenase, Pyr module [88742] (2 species)

Species:

  1. 483492Human (Homo sapiens) [TaxId:9606] [88743] (8 PDB entries)
    1. Domain for 1dtw:
    2. Domain for 1ols:
    3. Domain for 1olu:
    4. Domain for 1olx:
    5. Domain for 1v11:
    6. Domain for 1v16:
    7. Domain for 1v1m:
    8. Domain for 1v1r:
  2. 483501Thermus thermophilus [TaxId:274] [102332] (4 PDB entries)
    1. Domains for 1um9:
      1. 483506Domain d1um9b1: 1um9 B:2-187 [99582]
        Other proteins in same PDB: d1um9a_, d1um9b2, d1um9c_, d1um9d2
      2. 483507Domain d1um9d1: 1um9 D:2-187 [99585]
        Other proteins in same PDB: d1um9a_, d1um9b2, d1um9c_, d1um9d2
    2. Domains for 1umb:
      1. 483504Domain d1umbb1: 1umb B:2-187 [99588]
        Other proteins in same PDB: d1umba_, d1umbb2, d1umbc_, d1umbd2
      2. 483505Domain d1umbd1: 1umb D:2-187 [99591]
        Other proteins in same PDB: d1umba_, d1umbb2, d1umbc_, d1umbd2
    3. Domains for 1umc:
      1. 483508Domain d1umcb1: 1umc B:2-187 [99594]
        Other proteins in same PDB: d1umca_, d1umcb2, d1umcc_, d1umcd2
      2. 483509Domain d1umcd1: 1umc D:2-187 [99597]
        Other proteins in same PDB: d1umca_, d1umcb2, d1umcc_, d1umcd2
    4. Domains for 1umd:
      1. 483502Domain d1umdb1: 1umd B:2-187 [99600]
        Other proteins in same PDB: d1umda_, d1umdb2, d1umdc_, d1umdd2
      2. 483503Domain d1umdd1: 1umd D:2-187 [99603]
        Other proteins in same PDB: d1umda_, d1umdb2, d1umdc_, d1umdd2

More info for Protein Branched-chain alpha-keto acid dehydrogenase, Pyr module from c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module

Timeline for Protein Branched-chain alpha-keto acid dehydrogenase, Pyr module from c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module:

  • Protein Branched-chain alpha-keto acid dehydrogenase, Pyr module from c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module first appeared in SCOP 1.65
  • Protein Branched-chain alpha-keto acid dehydrogenase, Pyr module from c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module appears in SCOP 1.67
  • Protein Branched-chain alpha-keto acid dehydrogenase, Pyr module from c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module appears in SCOP 1.71
  • Protein Branched-chain alpha-keto acid dehydrogenase, Pyr module from c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module appears in the current release, SCOPe 2.08