SCOP 1.67: Protein: Branched-chain alpha-keto acid dehydrogenase, Pyr module

Lineage for Protein: Branched-chain alpha-keto acid dehydrogenase, Pyr module

Root: SCOP 1.67
Class c: Alpha and beta proteins (a/b) [51349] (130 folds)
Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (8 families)

there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules

Family c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module [88741] (3 proteins)
parent family to TK and PFOR
heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module

Protein Branched-chain alpha-keto acid dehydrogenase, Pyr module [88742] (2 species)

Species:

Human (Homo sapiens) [TaxId:9606] [88743] (4 PDB entries)
1. Domain for 1dtw:
  - Domain d1dtwb1: 1dtw B:17-204 [31828]
    Other proteins in same PDB: d1dtwa_, d1dtwb2
    complexed with k, mg, tdp
2. Domain for 1ols:
  - Domain d1olsb1: 1ols B:2-204 [93332]
    Other proteins in same PDB: d1olsa_, d1olsb2
    complexed with gol, k, mn, tdp
3. Domain for 1olu:
  - Domain d1olub1: 1olu B:2-204 [93336]
    Other proteins in same PDB: d1olua_, d1olub2
    complexed with gol, k, mg, tdp; mutant
4. Domain for 1olx:
  - Domain d1olxb1: 1olx B:2-204 [93339]
    Other proteins in same PDB: d1olxa_, d1olxb2
    complexed with gol, k, mn, tdp; mutant
Thermus thermophilus [TaxId:274] [102332] (4 PDB entries)
1. Domains for 1um9:
  1. Domain d1um9b1: 1um9 B:2-187 [99582]
    Other proteins in same PDB: d1um9a_, d1um9b2, d1um9c_, d1um9d2
  2. Domain d1um9d1: 1um9 D:2-187 [99585]
    Other proteins in same PDB: d1um9a_, d1um9b2, d1um9c_, d1um9d2
    complexed with so4
2. Domains for 1umb:
  1. Domain d1umbb1: 1umb B:2-187 [99588]
    Other proteins in same PDB: d1umba_, d1umbb2, d1umbc_, d1umbd2
  2. Domain d1umbd1: 1umb D:2-187 [99591]
    Other proteins in same PDB: d1umba_, d1umbb2, d1umbc_, d1umbd2
    complexed with mg, tdp
3. Domains for 1umc:
  1. Domain d1umcb1: 1umc B:2-187 [99594]
    Other proteins in same PDB: d1umca_, d1umcb2, d1umcc_, d1umcd2
  2. Domain d1umcd1: 1umc D:2-187 [99597]
    Other proteins in same PDB: d1umca_, d1umcb2, d1umcc_, d1umcd2
    complexed with 4mv, mg, tdp
4. Domains for 1umd:
  1. Domain d1umdb1: 1umd B:2-187 [99600]
    Other proteins in same PDB: d1umda_, d1umdb2, d1umdc_, d1umdd2
  2. Domain d1umdd1: 1umd D:2-187 [99603]
    Other proteins in same PDB: d1umda_, d1umdb2, d1umdc_, d1umdd2
    complexed with coi, mg, tdp

More info for Protein Branched-chain alpha-keto acid dehydrogenase, Pyr module from c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module

Timeline for Protein Branched-chain alpha-keto acid dehydrogenase, Pyr module from c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module:

Protein Branched-chain alpha-keto acid dehydrogenase, Pyr module from c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module first appeared in SCOP 1.65
Protein Branched-chain alpha-keto acid dehydrogenase, Pyr module from c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module appears in SCOP 1.69
Protein Branched-chain alpha-keto acid dehydrogenase, Pyr module from c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module appears in the current release, SCOPe 2.08