Lineage for Family c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module

  1. Root: SCOP 1.67
  2. 383641Class c: Alpha and beta proteins (a/b) [51349] (130 folds)
  3. 393047Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. 393048Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (8 families) (S)
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
  5. 393157Family c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module [88741] (3 proteins)
    parent family to TK and PFOR
    heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module

Proteins:

  1. 3931582-oxoisovalerate dehydrogenase (E1B), Pyr module [88744] (1 species)
    chain A is alpha-subunit and chain B is beta-subunit
  2. 393161Branched-chain alpha-keto acid dehydrogenase, Pyr module [88742] (2 species)
    1. 393162Species Human (Homo sapiens) [TaxId:9606] [88743] (4 PDB entries)
    2. 393167Species Thermus thermophilus [TaxId:274] [102332] (4 PDB entries)
  3. 393176E1-beta subunit of pyruvate dehydrogenase, Pyr module [69472] (2 species)
    1. 393177Species Archaeon Pyrobaculum aerophilum [TaxId:13773] [69473] (1 PDB entry)
    2. 393179Species Human (Homo sapiens) [TaxId:9606] [89653] (1 PDB entry)

More info for Family c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module

Timeline for Family c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module: