Lineage for Family c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2108258Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. 2108259Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families) (S)
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
  5. 2108430Family c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module [88741] (5 protein domains)
    parent family to TK and PFOR
    heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module
    automatically mapped to Pfam PF02779

Protein Domains:

  1. 21084312-oxoisovalerate dehydrogenase (E1B), Pyr module [88744] (1 species)
    chain A is alpha-subunit and chain B is beta-subunit
  2. 2108434Branched-chain alpha-keto acid dehydrogenase, Pyr module [88742] (2 species)
    1. 2108435Species Human (Homo sapiens) [TaxId:9606] [88743] (23 PDB entries)
      Uniprot P21953 52-392
    2. 2108459Species Thermus thermophilus [TaxId:274] [102332] (4 PDB entries)
  3. 2108468E1-beta subunit of pyruvate dehydrogenase, Pyr module [69472] (2 species)
    1. 2108469Species Human (Homo sapiens) [TaxId:9606] [89653] (4 PDB entries)
    2. 2108494Species Pyrobaculum aerophilum [TaxId:13773] [69473] (1 PDB entry)
  4. 2108496Pyruvate dehydrogenase E1-beta, PdhB, N-terminal domain [117522] (1 species)
  5. automated matches [254489] (1 species)
    not a true protein

More info for Family c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module

Timeline for Family c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module: