SCOPe 2.08: Family c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module

Lineage for Family c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

4. Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families)
   there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
   two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules

5. Family c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module [88741] (5 proteins)
   parent family to TK and PFOR
   heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module
   automatically mapped to Pfam PF02779

Proteins:

1. 2-oxoisovalerate dehydrogenase (E1B), Pyr module [88744] (1 species)
   chain A is alpha-subunit and chain B is beta-subunit

   • Species Pseudomonas putida [TaxId:303] [88745] (1 PDB entry)

2. Branched-chain alpha-keto acid dehydrogenase, Pyr module [88742] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [88743] (23 PDB entries)
      Uniprot P21953 52-392

   2. Species Thermus thermophilus [TaxId:274] [102332] (4 PDB entries)

3. E1-beta subunit of pyruvate dehydrogenase, Pyr module [69472] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [89653] (4 PDB entries)

   2. Species Pyrobaculum aerophilum [TaxId:13773] [69473] (1 PDB entry)

4. Pyruvate dehydrogenase E1-beta, PdhB, N-terminal domain [117522] (1 species)

   • Species Bacillus stearothermophilus [TaxId:1422] [117523] (2 PDB entries)
     Uniprot P21874

5. automated matches [254489] (1 species)
   not a true protein

   • Species Pseudomonas putida [TaxId:303] [255058] (1 PDB entry)

More info for Family c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module

Timeline for Family c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module:

• Family c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module first appeared in SCOP 1.65
  
• Family c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module appears in SCOPe 2.07