SCOPe 2.06: Protein: Transketolase (TK), Pyr module

Lineage for Protein: Transketolase (TK), Pyr module

Root: SCOPe 2.06
Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families)

there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules

Family c.36.1.6: TK-like Pyr module [88735] (2 proteins)
different order of the modules, PP module is N-terminal, Pyr module is next to it followed by a Rossmann-like domain
Protein Transketolase (TK), Pyr module [88736] (4 species)

Species:

Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [88737] (7 PDB entries)
1. Domains for 1ay0:
  1. Domain d1ay0a2: 1ay0 A:338-534 [31824]
    Other proteins in same PDB: d1ay0a1, d1ay0a3, d1ay0b1, d1ay0b3
    complexed with ca, tpp
  2. Domain d1ay0b2: 1ay0 B:338-534 [31826]
    Other proteins in same PDB: d1ay0a1, d1ay0a3, d1ay0b1, d1ay0b3
    complexed with ca, tpp
2. Domains for 1gpu:
  1. Domain d1gpua2: 1gpu A:338-534 [65455]
    Other proteins in same PDB: d1gpua1, d1gpua3, d1gpub1, d1gpub3
    complexed with ca, thd
  2. Domain d1gpub2: 1gpu B:338-534 [65458]
    Other proteins in same PDB: d1gpua1, d1gpua3, d1gpub1, d1gpub3
    complexed with ca, thd
3. Domains for 1ngs:
  1. Domain d1ngsa2: 1ngs A:338-534 [31820]
    Other proteins in same PDB: d1ngsa1, d1ngsa3, d1ngsb1, d1ngsb3
    complexed with ca, e4p, tpp
  2. Domain d1ngsb2: 1ngs B:338-534 [31822]
    Other proteins in same PDB: d1ngsa1, d1ngsa3, d1ngsb1, d1ngsb3
    complexed with ca, e4p, tpp
4. Domains for 1tka:
  1. Domain d1tkaa2: 1tka A:338-534 [31816]
    Other proteins in same PDB: d1tkaa1, d1tkaa3, d1tkab1, d1tkab3
    complexed with ca, n3t
  2. Domain d1tkab2: 1tka B:338-534 [31818]
    Other proteins in same PDB: d1tkaa1, d1tkaa3, d1tkab1, d1tkab3
    complexed with ca, n3t
5. Domains for 1tkb:
  1. Domain d1tkba2: 1tkb A:338-534 [31808]
    Other proteins in same PDB: d1tkba1, d1tkba3, d1tkbb1, d1tkbb3
    complexed with ca, n1t
  2. Domain d1tkbb2: 1tkb B:338-534 [31810]
    Other proteins in same PDB: d1tkba1, d1tkba3, d1tkbb1, d1tkbb3
    complexed with ca, n1t
6. Domains for 1tkc:
  1. Domain d1tkca2: 1tkc A:338-534 [31812]
    Other proteins in same PDB: d1tkca1, d1tkca3, d1tkcb1, d1tkcb3
    complexed with ca, m6t
  2. Domain d1tkcb2: 1tkc B:338-534 [31814]
    Other proteins in same PDB: d1tkca1, d1tkca3, d1tkcb1, d1tkcb3
    complexed with ca, m6t
7. Domains for 1trk:
  1. Domain d1trka2: 1trk A:338-534 [31804]
    Other proteins in same PDB: d1trka1, d1trka3, d1trkb1, d1trkb3
    complexed with ca, tpp
  2. Domain d1trkb2: 1trk B:338-534 [31806]
    Other proteins in same PDB: d1trka1, d1trka3, d1trkb1, d1trkb3
    complexed with ca, tpp
Escherichia coli [TaxId:562] [89650] (1 PDB entry)
- Domains for 1qgd:
  1. Domain d1qgda1: 1qgd A:333-527 [88367]
    Other proteins in same PDB: d1qgda2, d1qgda3, d1qgdb2, d1qgdb3
    complexed with ca, so4, tpp
  2. Domain d1qgdb1: 1qgd B:333-527 [88370]
    Other proteins in same PDB: d1qgda2, d1qgda3, d1qgdb2, d1qgdb3
    complexed with ca, so4, tpp
Leishmania mexicana mexicana [TaxId:44270] [117521] (1 PDB entry)
Uniprot Q8MPM3
- Domains for 1r9j:
  1. Domain d1r9ja1: 1r9j A:337-526 [111722]
    Other proteins in same PDB: d1r9ja2, d1r9ja3, d1r9ja4, d1r9jb2, d1r9jb3, d1r9jb4
    complexed with ca, tpp
  2. Domain d1r9jb1: 1r9j B:337-526 [111725]
    Other proteins in same PDB: d1r9ja2, d1r9ja3, d1r9ja4, d1r9jb2, d1r9jb3, d1r9jb4
    complexed with ca, tpp
Maize (Zea mays) [TaxId:4577] [88738] (1 PDB entry)
- Domains for 1itz:
  1. Domain d1itza2: 1itz A:348-539 [76798]
    Other proteins in same PDB: d1itza1, d1itza3, d1itzb1, d1itzb3, d1itzc1, d1itzc3
    complexed with mg, tpp
  2. Domain d1itzb2: 1itz B:348-539 [76801]
    Other proteins in same PDB: d1itza1, d1itza3, d1itzb1, d1itzb3, d1itzc1, d1itzc3
    complexed with mg, tpp
  3. Domain d1itzc2: 1itz C:348-539 [76804]
    Other proteins in same PDB: d1itza1, d1itza3, d1itzb1, d1itzb3, d1itzc1, d1itzc3
    complexed with mg, tpp

More info for Protein Transketolase (TK), Pyr module from c.36.1.6: TK-like Pyr module

Timeline for Protein Transketolase (TK), Pyr module from c.36.1.6: TK-like Pyr module:

Protein Transketolase (TK), Pyr module from c.36.1.6: TK-like Pyr module first appeared in SCOP 1.65
Protein Transketolase (TK), Pyr module from c.36.1.6: TK-like Pyr module appears in SCOPe 2.05
Protein Transketolase (TK), Pyr module from c.36.1.6: TK-like Pyr module appears in SCOPe 2.07
Protein Transketolase (TK), Pyr module from c.36.1.6: TK-like Pyr module appears in the current release, SCOPe 2.08