SCOPe 2.06: Protein: Acetohydroxyacid synthase catalytic subunit

Lineage for Protein: Acetohydroxyacid synthase catalytic subunit

Root: SCOPe 2.06
Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families)

there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules

Family c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module [88724] (8 proteins)
the N-terminal, Pyr module is separated from the C-terminal, PP module by an alpha/beta domain of Rossmann-like topology
automatically mapped to Pfam PF02776

Protein Acetohydroxyacid synthase catalytic subunit [88733] (3 species)

Species:

Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [88734] (10 PDB entries)
Uniprot P07342 84-687
1. Domains for 1jsc:
  1. Domain d1jsca2: 1jsc A:83-270 [67225]
    Other proteins in same PDB: d1jsca1, d1jsca3, d1jscb1, d1jscb3
    complexed with 2hp, fad, k, mg, tpp
  2. Domain d1jscb2: 1jsc B:82-272 [67228]
    Other proteins in same PDB: d1jsca1, d1jsca3, d1jscb1, d1jscb3
    complexed with 2hp, fad, k, mg, tpp
2. Domains for 1n0h:
  1. Domain d1n0ha2: 1n0h A:83-270 [79735]
    Other proteins in same PDB: d1n0ha1, d1n0ha3, d1n0hb1, d1n0hb3
    complexed with ayd, cie, dtt, fad, k, mg, tpp
  2. Domain d1n0hb2: 1n0h B:83-270 [79738]
    Other proteins in same PDB: d1n0ha1, d1n0ha3, d1n0hb1, d1n0hb3
    complexed with ayd, cie, dtt, fad, k, mg, tpp
3. Domains for 1t9a:
  1. Domain d1t9aa2: 1t9a A:89-263 [112329]
    Other proteins in same PDB: d1t9aa1, d1t9aa3, d1t9ab1, d1t9ab3
    complexed with 1tb, fad, k, mg, p23, yf3, yf4
  2. Domain d1t9ab2: 1t9a B:89-263 [112332]
    Other proteins in same PDB: d1t9aa1, d1t9aa3, d1t9ab1, d1t9ab3
    complexed with 1tb, fad, k, mg, p23, yf3, yf4
4. Domains for 1t9b:
  1. Domain d1t9ba2: 1t9b A:89-263 [112335]
    Other proteins in same PDB: d1t9ba1, d1t9ba3, d1t9bb1, d1t9bb3
    complexed with 1cs, fad, k, mg, nsp, p22, p25, yf3
  2. Domain d1t9bb2: 1t9b B:89-263 [112338]
    Other proteins in same PDB: d1t9ba1, d1t9ba3, d1t9bb1, d1t9bb3
    complexed with 1cs, fad, k, mg, nsp, p22, p25, yf3
5. Domains for 1t9c:
  1. Domain d1t9ca2: 1t9c A:89-263 [112341]
    Other proteins in same PDB: d1t9ca1, d1t9ca3, d1t9cb1, d1t9cb3
    complexed with 1sm, fad, k, mg, p22, p23
  2. Domain d1t9cb2: 1t9c B:89-263 [112344]
    Other proteins in same PDB: d1t9ca1, d1t9ca3, d1t9cb1, d1t9cb3
    complexed with 1sm, fad, k, mg, p22, p23
6. Domains for 1t9d:
  1. Domain d1t9da2: 1t9d A:89-263 [112347]
    Other proteins in same PDB: d1t9da1, d1t9da3, d1t9db1, d1t9db3, d1t9dc1, d1t9dc3, d1t9dd1, d1t9dd3
    complexed with 1mm, fad, k, mg, p22, p25, pyd
  2. Domain d1t9db2: 1t9d B:89-263 [112350]
    Other proteins in same PDB: d1t9da1, d1t9da3, d1t9db1, d1t9db3, d1t9dc1, d1t9dc3, d1t9dd1, d1t9dd3
    complexed with 1mm, fad, k, mg, p22, p25, pyd
  3. Domain d1t9dc2: 1t9d C:89-263 [112353]
    Other proteins in same PDB: d1t9da1, d1t9da3, d1t9db1, d1t9db3, d1t9dc1, d1t9dc3, d1t9dd1, d1t9dd3
    complexed with 1mm, fad, k, mg, p22, p25, pyd
  4. Domain d1t9dd2: 1t9d D:89-263 [112356]
    Other proteins in same PDB: d1t9da1, d1t9da3, d1t9db1, d1t9db3, d1t9dc1, d1t9dc3, d1t9dd1, d1t9dd3
    complexed with 1mm, fad, k, mg, p22, p25, pyd
7. Domains for 5inu:
  1. Domain d5inua1: 5inu A:83-271 [329893]
    Other proteins in same PDB: d5inua2, d5inub2
    automated match to d1n0ha2
    complexed with fad, k, mg, oxy, po4, pyr, tpp
  2. Domain d5inub1: 5inu B:83-270 [329825]
    Other proteins in same PDB: d5inua2, d5inub2
    automated match to d1n0ha2
    complexed with fad, k, mg, oxy, po4, pyr, tpp
8. Domains for 5inv:
  1. Domain d5inva1: 5inv A:83-270 [329757]
    Other proteins in same PDB: d5inva2, d5invb2
    automated match to d1n0ha2
    complexed with bct, co2, fad, htl, k, mg, oxy, po4, tpp
  2. Domain d5invb1: 5inv B:84-270 [329784]
    Other proteins in same PDB: d5inva2, d5invb2
    automated match to d1n0ha2
    complexed with bct, co2, fad, htl, k, mg, oxy, po4, tpp
9. Domains for 6bd3:
  1. Domain d6bd3a1: 6bd3 A:83-270 [341189]
    Other proteins in same PDB: d6bd3a2, d6bd3b2
    automated match to d1n0ha2
    complexed with act, co2, fad, htl, k, mg, oxy, po4, tpp
  2. Domain d6bd3b1: 6bd3 B:84-270 [341191]
    Other proteins in same PDB: d6bd3a2, d6bd3b2
    automated match to d1n0ha2
    complexed with act, co2, fad, htl, k, mg, oxy, po4, tpp
10. Domains for 6bd9:
  1. Domain d6bd9a1: 6bd9 A:83-271 [341294]
    Other proteins in same PDB: d6bd9a2, d6bd9b2
    automated match to d1n0ha2
    complexed with fad, k, mg, oxy, po4, pyr, tpp
  2. Domain d6bd9b1: 6bd9 B:83-270 [341350]
    Other proteins in same PDB: d6bd9a2, d6bd9b2
    automated match to d1n0ha2
    complexed with fad, k, mg, oxy, po4, pyr, tpp
Saccharomyces cerevisiae [TaxId:559292] [314106] (2 PDB entries)
1. Domains for 5fem:
  1. Domain d5fema1: 5fem A:83-270 [314121]
    Other proteins in same PDB: d5fema2, d5fema3, d5femb2, d5femb3
    automated match to d1n0ha2
    complexed with 60g, fad, mg, tpp
  2. Domain d5femb1: 5fem B:83-270 [314107]
    Other proteins in same PDB: d5fema2, d5fema3, d5femb2, d5femb3
    automated match to d1n0ha2
    complexed with 60g, fad, mg, tpp
2. Domains for 5ims:
  1. Domain d5imsa1: 5ims A:83-271 [329726]
    Other proteins in same PDB: d5imsa2, d5imsb2
    automated match to d1n0ha2
    complexed with act, fad, k, mg, oxy, po4, tpp
  2. Domain d5imsb1: 5ims B:83-270 [329799]
    Other proteins in same PDB: d5imsa2, d5imsb2
    automated match to d1n0ha2
    complexed with act, fad, k, mg, oxy, po4, tpp
Thale cress (Arabidopsis thaliana), chloroplast [TaxId:3702] [142204] (11 PDB entries)
Uniprot P17597 86-280
1. Domain for 1ybh:
  - Domain d1ybha2: 1ybh A:86-280 [122892]
    Other proteins in same PDB: d1ybha1, d1ybha3
    complexed with cie, fad, mg, nhe, p22
2. Domain for 1yhy:
  - Domain d1yhya2: 1yhy A:86-280 [123216]
    Other proteins in same PDB: d1yhya1, d1yhya3
    automated match to d1ybha2
    complexed with 1mm, fad, mg, nhe, p22
3. Domain for 1yhz:
  - Domain d1yhza2: 1yhz A:86-280 [123219]
    Other proteins in same PDB: d1yhza1, d1yhza3
    automated match to d1ybha2
    complexed with 1cs, fad, mg, nhe, p22
4. Domain for 1yi0:
  - Domain d1yi0a2: 1yi0 A:86-280 [123222]
    Other proteins in same PDB: d1yi0a1, d1yi0a3
    automated match to d1ybha2
    complexed with 1sm, fad, mg, nhe, p22
5. Domain for 1yi1:
  - Domain d1yi1a2: 1yi1 A:86-280 [123225]
    Other proteins in same PDB: d1yi1a1, d1yi1a3
    automated match to d1ybha2
    complexed with 1tb, fad, mg, nhe, p22
6. Domain for 1z8n:
  - Domain d1z8na2: 1z8n A:86-280 [124720]
    Other proteins in same PDB: d1z8na1, d1z8na3
    automated match to d1ybha2
    complexed with 1iq, fad, mg, nhe, tpp
7. Domain for 5k2o:
  - Domain d5k2oa1: 5k2o A:86-280 [329452]
    Other proteins in same PDB: d5k2oa2, d5k2oa3, d5k2oa4
    automated match to d1ybha2
    complexed with 6qk, cit, fad, mg, tp9
8. Domain for 5k3s:
  - Domain d5k3sa1: 5k3s A:86-280 [329458]
    Other proteins in same PDB: d5k3sa2, d5k3sa3, d5k3sa4
    automated match to d1ybha2
    complexed with 6ql, fad, mg, tp9
9. Domain for 5k6q:
  - Domain d5k6qa1: 5k6q A:86-280 [334840]
    Other proteins in same PDB: d5k6qa2, d5k6qa3
    automated match to d1ybha2
    complexed with fad, mg, nhe, tdm
10. Domain for 5k6r:
  - Domain d5k6ra1: 5k6r A:86-280 [329462]
    Other proteins in same PDB: d5k6ra2, d5k6ra3
    automated match to d1ybha2
    complexed with 6r5, fad, k, mg, nhe, tzd
11. Domain for 5k6t:
  - Domain d5k6ta1: 5k6t A:86-280 [329467]
    Other proteins in same PDB: d5k6ta2, d5k6ta3
    automated match to d1ybha2
    complexed with 6r4, fad, k, mg, nhe, tzd

More info for Protein Acetohydroxyacid synthase catalytic subunit from c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module

Timeline for Protein Acetohydroxyacid synthase catalytic subunit from c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module:

Protein Acetohydroxyacid synthase catalytic subunit from c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module first appeared in SCOP 1.65
Protein Acetohydroxyacid synthase catalytic subunit from c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module appears in SCOPe 2.05
Protein Acetohydroxyacid synthase catalytic subunit from c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module appears in SCOPe 2.07
Protein Acetohydroxyacid synthase catalytic subunit from c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module appears in the current release, SCOPe 2.08