SCOP 1.67: Protein: Acetohydroxyacid synthase catalytic subunit

Lineage for Protein: Acetohydroxyacid synthase catalytic subunit

Root: SCOP 1.67
Class c: Alpha and beta proteins (a/b) [51349] (130 folds)
Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (8 families)

there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules

Family c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module [88724] (7 proteins)
the N-terminal, Pyr module is separated from the C-terminal, PP module by an alpha/beta domain of Rossmann-like topology

Protein Acetohydroxyacid synthase catalytic subunit [88733] (1 species)

Species:

Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [88734] (2 PDB entries)
1. Domains for 1jsc:
  1. Domain d1jsca2: 1jsc A:83-270 [67225]
    Other proteins in same PDB: d1jsca1, d1jsca3, d1jscb1, d1jscb3
  2. Domain d1jscb2: 1jsc B:82-272 [67228]
    Other proteins in same PDB: d1jsca1, d1jsca3, d1jscb1, d1jscb3
    complexed with 2hp, fad, k, mg, tpp
2. Domains for 1n0h:
  1. Domain d1n0ha2: 1n0h A:83-270 [79735]
    Other proteins in same PDB: d1n0ha1, d1n0ha3, d1n0hb1, d1n0hb3
  2. Domain d1n0hb2: 1n0h B:83-270 [79738]
    Other proteins in same PDB: d1n0ha1, d1n0ha3, d1n0hb1, d1n0hb3
    complexed with ayd, cie, dtt, fad, k, mg, tpp

More info for Protein Acetohydroxyacid synthase catalytic subunit from c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module

Timeline for Protein Acetohydroxyacid synthase catalytic subunit from c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module:

Protein Acetohydroxyacid synthase catalytic subunit from c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module first appeared in SCOP 1.65
Protein Acetohydroxyacid synthase catalytic subunit from c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module appears in SCOP 1.69
Protein Acetohydroxyacid synthase catalytic subunit from c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module appears in the current release, SCOPe 2.08