SCOPe 2.06: Protein: Pyruvate oxidase

Lineage for Protein: Pyruvate oxidase

Root: SCOPe 2.06
Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families)

there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules

Family c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module [88724] (8 proteins)
the N-terminal, Pyr module is separated from the C-terminal, PP module by an alpha/beta domain of Rossmann-like topology
automatically mapped to Pfam PF02776

Protein Pyruvate oxidase [88729] (2 species)

Species:

Aerococcus viridans [TaxId:1377] [142203] (2 PDB entries)
1. Domain for 1v5e:
  - Domain d1v5ea2: 1v5e A:3-186 [119845]
    Other proteins in same PDB: d1v5ea1, d1v5ea3
    complexed with fad, so4
2. Domain for 2dji:
  - Domain d2djia2: 2dji A:3-186 [131545]
    Other proteins in same PDB: d2djia1, d2djia3
    automated match to d1v5ea2
    complexed with fad, so4
Lactobacillus plantarum [TaxId:1590] [88730] (2 PDB entries)
1. Domains for 1pow:
  1. Domain d1powa2: 1pow A:9-182 [31797]
    Other proteins in same PDB: d1powa1, d1powa3, d1powb1, d1powb3
    complexed with fad, mg, tpp; mutant
  2. Domain d1powb2: 1pow B:9-182 [31799]
    Other proteins in same PDB: d1powa1, d1powa3, d1powb1, d1powb3
    complexed with fad, mg, tpp; mutant
2. Domains for 1pox:
  1. Domain d1poxa2: 1pox A:9-182 [31793]
    Other proteins in same PDB: d1poxa1, d1poxa3, d1poxb1, d1poxb3
    complexed with fad, gol, mg, na, tpp; mutant
  2. Domain d1poxb2: 1pox B:9-182 [31795]
    Other proteins in same PDB: d1poxa1, d1poxa3, d1poxb1, d1poxb3
    complexed with fad, gol, mg, na, tpp; mutant

More info for Protein Pyruvate oxidase from c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module

Timeline for Protein Pyruvate oxidase from c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module:

Protein Pyruvate oxidase from c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module first appeared in SCOP 1.65
Protein Pyruvate oxidase from c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module appears in SCOPe 2.05
Protein Pyruvate oxidase from c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module appears in SCOPe 2.07
Protein Pyruvate oxidase from c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module appears in the current release, SCOPe 2.08