SCOP 1.73: Protein: Pyruvate oxidase

Lineage for Protein: Pyruvate oxidase

Root: SCOP 1.73
Class c: Alpha and beta proteins (a/b) [51349] (141 folds)
Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (8 families)

there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules

Family c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module [88724] (8 proteins)
the N-terminal, Pyr module is separated from the C-terminal, PP module by an alpha/beta domain of Rossmann-like topology

Protein Pyruvate oxidase [88729] (2 species)

Species:

Aerococcus viridans [TaxId:1377] [142203] (4 PDB entries)
1. Domain for 1v5e:
  - Domain d1v5ea2: 1v5e A:3-186 [119845]
    Other proteins in same PDB: d1v5ea1, d1v5ea3
    complexed with fad, so4
2. Domain for 1v5f:
  - Domain d1v5fa2: 1v5f A:4-186 [119848]
    Other proteins in same PDB: d1v5fa1, d1v5fa3
    automatically matched to 1V5E A:3-186
    complexed with fad, mg, so4, tpp
3. Domain for 1v5g:
  - Domain d1v5ga2: 1v5g A:4-186 [119851]
    Other proteins in same PDB: d1v5ga1, d1v5ga3
    automatically matched to 1V5E A:3-186
    complexed with fad, htl, mg
4. Domain for 2dji:
  - Domain d2djia2: 2dji A:3-186 [131545]
    Other proteins in same PDB: d2djia1, d2djia3
    automatically matched to 1V5E A:3-186
    complexed with fad, so4
Lactobacillus plantarum [TaxId:1590] [88730] (7 PDB entries)
1. Domains for 1pow:
  1. Domain d1powa2: 1pow A:9-182 [31797]
    Other proteins in same PDB: d1powa1, d1powa3, d1powb1, d1powb3
  2. Domain d1powb2: 1pow B:9-182 [31799]
    Other proteins in same PDB: d1powa1, d1powa3, d1powb1, d1powb3
    complexed with fad, mg, tpp
2. Domains for 1pox:
  1. Domain d1poxa2: 1pox A:9-182 [31793]
    Other proteins in same PDB: d1poxa1, d1poxa3, d1poxb1, d1poxb3
  2. Domain d1poxb2: 1pox B:9-182 [31795]
    Other proteins in same PDB: d1poxa1, d1poxa3, d1poxb1, d1poxb3
    complexed with fad, gol, mg, na, tpp; mutant
3. Domains for 2ez4:
  1. Domain d2ez4a2: 2ez4 A:9-182 [132611]
    Other proteins in same PDB: d2ez4a1, d2ez4a3, d2ez4b1, d2ez4b3
    automatically matched to d1powa2
    complexed with fad, mg, na, po4, tpp; mutant
  2. Domain d2ez4b2: 2ez4 B:9-182 [132614]
    Other proteins in same PDB: d2ez4a1, d2ez4a3, d2ez4b1, d2ez4b3
    automatically matched to d1powa2
    complexed with fad, mg, na, po4, tpp; mutant
4. Domains for 2ez8:
  1. Domain d2ez8a2: 2ez8 A:9-182 [132622]
    Other proteins in same PDB: d2ez8a1, d2ez8a3, d2ez8b1, d2ez8b3
    automatically matched to d1powa2
    complexed with fad, mg, na, pyr, tdl; mutant
  2. Domain d2ez8b2: 2ez8 B:9-182 [132625]
    Other proteins in same PDB: d2ez8a1, d2ez8a3, d2ez8b1, d2ez8b3
    automatically matched to d1powa2
    complexed with fad, mg, na, pyr, tdl; mutant
5. Domains for 2ez9:
  1. Domain d2ez9a2: 2ez9 A:9-182 [132628]
    Other proteins in same PDB: d2ez9a1, d2ez9a3, d2ez9b1, d2ez9b3
    automatically matched to d1powa2
    complexed with fad, mg, na, tdk; mutant
  2. Domain d2ez9b2: 2ez9 B:9-182 [132631]
    Other proteins in same PDB: d2ez9a1, d2ez9a3, d2ez9b1, d2ez9b3
    automatically matched to d1powa2
    complexed with fad, mg, na, tdk; mutant
6. Domains for 2ezt:
  1. Domain d2ezta2: 2ezt A:9-182 [132634]
    Other proteins in same PDB: d2ezta1, d2ezta3, d2eztb1, d2eztb3
    automatically matched to d1powa2
    complexed with fad, mg, na, po4, pyr, tdm; mutant
  2. Domain d2eztb2: 2ezt B:9-182 [132637]
    Other proteins in same PDB: d2ezta1, d2ezta3, d2eztb1, d2eztb3
    automatically matched to d1powa2
    complexed with fad, mg, na, po4, pyr, tdm; mutant
7. Domains for 2ezu:
  1. Domain d2ezua2: 2ezu A:9-182 [132640]
    Other proteins in same PDB: d2ezua1, d2ezua3, d2ezub1, d2ezub3
    automatically matched to d1powa2
    complexed with fad, htl, mg, na, pyr; mutant
  2. Domain d2ezub2: 2ezu B:9-182 [132643]
    Other proteins in same PDB: d2ezua1, d2ezua3, d2ezub1, d2ezub3
    automatically matched to d1powa2
    complexed with fad, htl, mg, na, pyr; mutant

More info for Protein Pyruvate oxidase from c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module

Timeline for Protein Pyruvate oxidase from c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module:

Protein Pyruvate oxidase from c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module first appeared in SCOP 1.65
Protein Pyruvate oxidase from c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module appears in SCOP 1.71
Protein Pyruvate oxidase from c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module appears in SCOP 1.75
Protein Pyruvate oxidase from c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module appears in the current release, SCOPe 2.08