SCOPe 2.05: Family c.6.2.1: alpha-mannosidase

Lineage for Family c.6.2.1: alpha-mannosidase

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.6: 7-stranded beta/alpha barrel [51988] (3 superfamilies)
   variant of beta/alpha barrel; parallel beta-sheet barrel, closed, n=7, S=8; strand order 1234567; some members may have fewer strands

4. Superfamily c.6.2: Glycoside hydrolase/deacetylase [88713] (9 families)
   in the different families beta-barrels are similarly distorted but may vary in the number of strands

5. Family c.6.2.1: alpha-mannosidase [88714] (2 proteins)
   family 38 glycoside hydrolase; overall domain organization is similar to that of the 4-alpha-glucanotransferase family

Proteins:

1. Golgi alpha-mannosidase II [88715] (1 species)

   • Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [88716] (57 PDB entries)
     Uniprot Q24451 94-1107

2. Lysosomal alpha-mannosidase [89557] (1 species)
   the single-chain precursor is processed into 5 peptides; heavily glycosylated

   • Species Cow (Bos taurus) [TaxId:9913] [89558] (1 PDB entry)

More info for Family c.6.2.1: alpha-mannosidase

Timeline for Family c.6.2.1: alpha-mannosidase:

• Family c.6.2.1: alpha-mannosidase first appeared in SCOP 1.65
  
• Family c.6.2.1: alpha-mannosidase appears in SCOPe 2.04
  
• Family c.6.2.1: alpha-mannosidase appears in SCOPe 2.06
  
• Family c.6.2.1: alpha-mannosidase appears in the current release, SCOPe 2.08