SCOPe 2.01: Family a.8.3.1: alpha-mannosidase, domain 2

Lineage for Family a.8.3.1: alpha-mannosidase, domain 2

1. Root: SCOPe 2.01

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.8: immunoglobulin/albumin-binding domain-like [46996] (11 superfamilies)
   3 helices; bundle, closed, left-handed twist; up-and-down; mirror topology to the spectrin-like fold

4. Superfamily a.8.3: Families 57/38 glycoside transferase middle domain [88688] (3 families)

5. Family a.8.3.1: alpha-mannosidase, domain 2 [88693] (2 proteins)
   family 38 glycoside hydrolase; overall domain organization is similar to that of the 4-alpha-glucanotransferase family

Proteins:

1. Golgi alpha-mannosidase II [88694] (1 species)

   • Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [88695] (46 PDB entries)
     Uniprot Q24451 94-1107

2. Lysosomal alpha-mannosidase [89016] (1 species)
   the single-chain precursor is processed into 5 peptides; heavily glycosylated

   • Species Cow (Bos taurus) [TaxId:9913] [89017] (1 PDB entry)

More info for Family a.8.3.1: alpha-mannosidase, domain 2

Timeline for Family a.8.3.1: alpha-mannosidase, domain 2:

• Family a.8.3.1: alpha-mannosidase, domain 2 first appeared in SCOP 1.65
  
• Family a.8.3.1: alpha-mannosidase, domain 2 appears in SCOP 1.75
  
• Family a.8.3.1: alpha-mannosidase, domain 2 appears in SCOPe 2.02
  
• Family a.8.3.1: alpha-mannosidase, domain 2 appears in the current release, SCOPe 2.08