SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Superfamily b.121.4: Positive stranded ssRNA viruses

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2075417Fold b.121: Nucleoplasmin-like/VP (viral coat and capsid proteins) [88632] (7 superfamilies)
    sandwich; 8 strands in 2 sheets; jelly-roll; some members can have additional 1-2 strands
    characteristic interaction between the domains of this fold allows the formation of five-fold and pseudo six-fold assemblies
  4. 2075626Superfamily b.121.4: Positive stranded ssRNA viruses [88633] (10 families) (S)

Families:

  1. 2075627b.121.4.1: Picornaviridae-like VP (VP1, VP2, VP3 and VP4) [88634] (10 protein domains)
    the order of the chains N-VP0-VP3-VP1-C is as in the polyprotein; VP0 is cleaved later upon capsid assembly to VP4 and VP2
    there is a different order in the shuffled genome of insect picorna-like proteins (Cricket paralysis virus)
  2. 2075967b.121.4.2: Comoviridae-like VP [88636] (3 protein domains)
    duplication: mature coat protein consists of three similar domains that can be in a single chain or in two separate chains
  3. 2075995b.121.4.3: Caliciviridae-like VP [88637] (1 protein)
  4. 2076001b.121.4.4: Nodaviridae-like VP [88638] (1 protein)
  5. 2076015b.121.4.5: Bromoviridae-like VP [88639] (2 protein domains)
  6. 2076068b.121.4.6: Tymoviridae-like VP [88641] (2 protein domains)
    automatically mapped to Pfam PF00983
  7. 2076096b.121.4.7: Tombusviridae-like VP [88643] (5 protein domains)
  8. 2076140b.121.4.8: Tetraviridae-like VP [101568] (1 protein)
    automatically mapped to Pfam PF03566
  9. 2076147b.121.4.9: Birnaviridae-like VP [141109] (2 protein domains)
    dsRNA virus but unlike the other dsRNA viruses has a genomic arrangement and genomic replication strategy similar to +sRNA viruses; includes Pfam PF01766; Birnavirus VP2 protein
  10. 2076195b.121.4.0: automated matches [191569] (1 protein)
    not a true family

More info for Superfamily b.121.4: Positive stranded ssRNA viruses

Timeline for Superfamily b.121.4: Positive stranded ssRNA viruses: