Lineage for Species: Engineered (including hybrid species)

  1. Root: SCOP 1.67
  2. 362614Class b: All beta proteins [48724] (141 folds)
  3. 362615Fold b.1: Immunoglobulin-like beta-sandwich [48725] (22 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 362616Superfamily b.1.1: Immunoglobulin [48726] (4 families) (S)
  5. 362617Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (24 proteins)
  6. 362751Protein Immunoglobulin heavy chain variable domain, VH [88543] (20 species)
    VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species
  7. 362752Species Engineered (including hybrid species) [88562] (28 PDB entries)

PDB entries in Species: Engineered (including hybrid species):

  1. Domain(s) for 1ad0:
    1. 362773Domain d1ad0b1: 1ad0 B:1-113 [20125]
      Other proteins in same PDB: d1ad0a1, d1ad0a2, d1ad0b2, d1ad0c1, d1ad0c2, d1ad0d2
    2. 362774Domain d1ad0d1: 1ad0 D:1-113 [20127]
      Other proteins in same PDB: d1ad0a1, d1ad0a2, d1ad0b2, d1ad0c1, d1ad0c2, d1ad0d2
      part of humanized Fab A5B7
  2. Domain(s) for 1ad9:
    1. 362780Domain d1ad9b1: 1ad9 B:1-113 [20215]
      Other proteins in same PDB: d1ad9a1, d1ad9a2, d1ad9b2, d1ad9h2, d1ad9l1, d1ad9l2
      part of humanized Fab CTM01
      complexed with so4
    2. 362781Domain d1ad9h1: 1ad9 H:1-113 [20213]
      Other proteins in same PDB: d1ad9a1, d1ad9a2, d1ad9b2, d1ad9h2, d1ad9l1, d1ad9l2
  3. Domain(s) for 1b2w:
  4. Domain(s) for 1bvk:
    1. 362784Domain d1bvkb_: 1bvk B: [20279]
      Other proteins in same PDB: d1bvka_, d1bvkc_, d1bvkd_, d1bvkf_
    2. 362785Domain d1bvke_: 1bvk E: [20281]
      Other proteins in same PDB: d1bvka_, d1bvkc_, d1bvkd_, d1bvkf_
      part of humanized anti-lysozyme Fv HuLys11
  5. Domain(s) for 1bvl:
    1. 362787Domain d1bvla_: 1bvl A: [20282]
      Other proteins in same PDB: d1bvlb_, d1bvld_
    2. 362788Domain d1bvlc_: 1bvl C: [20284]
      Other proteins in same PDB: d1bvlb_, d1bvld_
      part of humanized anti-lysozyme Fv HuLys11
  6. Domain(s) for 1fgv:
  7. Domain(s) for 1fvc:
    1. 362766Domain d1fvcb_: 1fvc B: [19863]
      Other proteins in same PDB: d1fvca_, d1fvcc_
    2. 362767Domain d1fvcd_: 1fvc D: [19865]
      Other proteins in same PDB: d1fvca_, d1fvcc_
      part of humanized Fv 4D5, herceptin
  8. Domain(s) for 1fvd:
    1. 362771Domain d1fvdb1: 1fvd B:1-120 [19867]
      Other proteins in same PDB: d1fvda1, d1fvda2, d1fvdb2, d1fvdc1, d1fvdc2, d1fvdd2
    2. 362772Domain d1fvdd1: 1fvd D:1-120 [19869]
      Other proteins in same PDB: d1fvda1, d1fvda2, d1fvdb2, d1fvdc1, d1fvdc2, d1fvdd2
      part of humanized Fab 4D5, herceptin
  9. Domain(s) for 1fve:
    1. 362775Domain d1fveb1: 1fve B:1-120 [19871]
      Other proteins in same PDB: d1fvea1, d1fvea2, d1fveb2, d1fvec1, d1fvec2, d1fved2
    2. 362776Domain d1fved1: 1fve D:1-120 [19873]
      Other proteins in same PDB: d1fvea1, d1fvea2, d1fveb2, d1fvec1, d1fvec2, d1fved2
      part of humanized Fab 4D5, herceptin
  10. Domain(s) for 1gpo:
    1. 362763Domain d1gpoh1: 1gpo H:1-113 [20225]
      Other proteins in same PDB: d1gpoh2, d1gpoi2, d1gpol1, d1gpol2, d1gpom1, d1gpom2
    2. 362764Domain d1gpoi1: 1gpo I:1-113 [20227]
      Other proteins in same PDB: d1gpoh2, d1gpoi2, d1gpol1, d1gpol2, d1gpom1, d1gpom2
      part of Fab M41 (artificial design)
      complexed with so4
  11. Domain(s) for 1i9r:
    1. 362791Domain d1i9rh1: 1i9r H:1-118 [71151]
      Other proteins in same PDB: d1i9ra_, d1i9rb_, d1i9rc_, d1i9rh2, d1i9rk2, d1i9rl1, d1i9rl2, d1i9rm1, d1i9rm2, d1i9rx2, d1i9ry1, d1i9ry2
    2. 362792Domain d1i9rk1: 1i9r K:1-118 [71153]
      Other proteins in same PDB: d1i9ra_, d1i9rb_, d1i9rc_, d1i9rh2, d1i9rk2, d1i9rl1, d1i9rl2, d1i9rm1, d1i9rm2, d1i9rx2, d1i9ry1, d1i9ry2
    3. 362793Domain d1i9rx1: 1i9r X:1-118 [71159]
      Other proteins in same PDB: d1i9ra_, d1i9rb_, d1i9rc_, d1i9rh2, d1i9rk2, d1i9rl1, d1i9rl2, d1i9rm1, d1i9rm2, d1i9rx2, d1i9ry1, d1i9ry2
      complexed with zn
  12. Domain(s) for 1it9:
  13. Domain(s) for 1jps:
  14. Domain(s) for 1jpt:
  15. Domain(s) for 1l7i:
  16. Domain(s) for 1mhp:
    1. 362778Domain d1mhph1: 1mhp H:1-118 [84967]
      Other proteins in same PDB: d1mhpa_, d1mhpb_, d1mhph2, d1mhpl1, d1mhpl2, d1mhpy_
      part of humanized anti-alpha1 integrin I-domain Fab
      complexed with mn; mutant
    2. 362779Domain d1mhpx_: 1mhp X: [84971]
      Other proteins in same PDB: d1mhpa_, d1mhpb_, d1mhph2, d1mhpl1, d1mhpl2, d1mhpy_
      part of humanized anti-alpha1 integrin I-domain Fab; only V domain is ordered
      complexed with mn; mutant
  17. Domain(s) for 1n8z:
  18. Domain(s) for 1ohq:
    1. 362761Domain d1ohqa_: 1ohq A: [93027]
    2. 362762Domain d1ohqb_: 1ohq B: [93028]
      soluble VH Hel4, resistant to aggregation
  19. Domain(s) for 1ol0:
    1. 362753Domain d1ol0a_: 1ol0 A: [93296]
    2. 362754Domain d1ol0b_: 1ol0 B: [93297]
      camelized human VH
      complexed with gol, so4
  20. Domain(s) for 1om3:
    1. 362769Domain d1om3h1: 1om3 H:1-115 [87059]
      Other proteins in same PDB: d1om3h2, d1om3k2, d1om3l1, d1om3l2, d1om3m1, d1om3m2
    2. 362770Domain d1om3k1: 1om3 K:1-115 [87061]
      Other proteins in same PDB: d1om3h2, d1om3k2, d1om3l1, d1om3l2, d1om3m1, d1om3m2
      part of engineered Fab 2G12
  21. Domain(s) for 1op3:
    1. 362759Domain d1op3h1: 1op3 H:1-115 [87208]
      Other proteins in same PDB: d1op3h2, d1op3k1, d1op3k2, d1op3l1, d1op3l2, d1op3m2
    2. 362760Domain d1op3m1: 1op3 M:1-115 [87214]
      Other proteins in same PDB: d1op3h2, d1op3k1, d1op3k2, d1op3l1, d1op3l2, d1op3m2
      part of engineered Fab 2G12
      complexed with box, man
  22. Domain(s) for 1op5:
    1. 362796Domain d1op5h1: 1op5 H:1-115 [87216]
      Other proteins in same PDB: d1op5h2, d1op5k1, d1op5k2, d1op5l1, d1op5l2, d1op5m2
    2. 362797Domain d1op5m1: 1op5 M:1-115 [87222]
      Other proteins in same PDB: d1op5h2, d1op5k1, d1op5k2, d1op5l1, d1op5l2, d1op5m2
      part of engineered Fab 2G12
      complexed with man, nag
  23. Domain(s) for 1pg7:
    1. 362789Domain d1pg7h1: 1pg7 H:1-117 [94674]
      Other proteins in same PDB: d1pg7h2, d1pg7i2, d1pg7l1, d1pg7l2, d1pg7m1, d1pg7m2, d1pg7w1, d1pg7w2, d1pg7x1, d1pg7x2, d1pg7y1, d1pg7y2, d1pg7z1, d1pg7z2
    2. 362790Domain d1pg7i1: 1pg7 I:1-117 [94676]
      Other proteins in same PDB: d1pg7h2, d1pg7i2, d1pg7l1, d1pg7l2, d1pg7m1, d1pg7m2, d1pg7w1, d1pg7w2, d1pg7x1, d1pg7x2, d1pg7y1, d1pg7y2, d1pg7z1, d1pg7z2
      part of humanized Fab D3H44 against human tissue factor
  24. Domain(s) for 1s78:
    1. 362794Domain d1s78d1: 1s78 D:1-113 [98626]
      Other proteins in same PDB: d1s78a1, d1s78a2, d1s78a3, d1s78a4, d1s78b1, d1s78b2, d1s78b3, d1s78b4, d1s78c1, d1s78c2, d1s78d2, d1s78e1, d1s78e2, d1s78f2
    2. 362795Domain d1s78f1: 1s78 F:1-113 [98630]
      Other proteins in same PDB: d1s78a1, d1s78a2, d1s78a3, d1s78a4, d1s78b1, d1s78b2, d1s78b3, d1s78b4, d1s78c1, d1s78c2, d1s78d2, d1s78e1, d1s78e2, d1s78f2
      part of anti-ERBb2 Fab Pertuzumab
      complexed with man, nag
  25. Domain(s) for 1vhp:
  26. Domain(s) for 2f5a:
  27. Domain(s) for 2f5b:
  28. Domain(s) for 2fgw:

More info for Species Engineered (including hybrid species) from b.1.1.1 Immunoglobulin heavy chain variable domain, VH

Timeline for Species Engineered (including hybrid species) from b.1.1.1 Immunoglobulin heavy chain variable domain, VH: