Lineage for Species: Engineered (including hybrid species)

  1. Root: SCOP 1.65
  2. 287094Class b: All beta proteins [48724] (126 folds)
  3. 287095Fold b.1: Immunoglobulin-like beta-sandwich [48725] (20 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 287096Superfamily b.1.1: Immunoglobulin [48726] (4 families) (S)
  5. 287097Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (21 proteins)
  6. 287195Protein Immunoglobulin heavy chain variable domain, VH [88543] (19 species)
    VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogeneous CDRs are listed as engineered species
  7. 287196Species Engineered (including hybrid species) [88562] (24 PDB entries)

PDB entries in Species: Engineered (including hybrid species):

  1. Domain(s) for 1ad0:
    1. 287213Domain d1ad0b1: 1ad0 B:1-113 [20125]
      Other proteins in same PDB: d1ad0a1, d1ad0a2, d1ad0b2, d1ad0c1, d1ad0c2, d1ad0d2
    2. 287214Domain d1ad0d1: 1ad0 D:1-113 [20127]
      Other proteins in same PDB: d1ad0a1, d1ad0a2, d1ad0b2, d1ad0c1, d1ad0c2, d1ad0d2
      part of humanized Fab A5B7
  2. Domain(s) for 1ad9:
    1. 287220Domain d1ad9b1: 1ad9 B:1-113 [20215]
      Other proteins in same PDB: d1ad9a1, d1ad9a2, d1ad9b2, d1ad9h2, d1ad9l1, d1ad9l2
      part of humanized Fab CTM01
      complexed with so4
    2. 287221Domain d1ad9h1: 1ad9 H:1-113 [20213]
      Other proteins in same PDB: d1ad9a1, d1ad9a2, d1ad9b2, d1ad9h2, d1ad9l1, d1ad9l2
  3. Domain(s) for 1b2w:
  4. Domain(s) for 1bvk:
    1. 287224Domain d1bvkb_: 1bvk B: [20279]
      Other proteins in same PDB: d1bvka_, d1bvkc_, d1bvkd_, d1bvkf_
    2. 287225Domain d1bvke_: 1bvk E: [20281]
      Other proteins in same PDB: d1bvka_, d1bvkc_, d1bvkd_, d1bvkf_
      part of humanized anti-lysozyme Fv HuLys11
  5. Domain(s) for 1bvl:
    1. 287227Domain d1bvla_: 1bvl A: [20282]
      Other proteins in same PDB: d1bvlb_, d1bvld_
    2. 287228Domain d1bvlc_: 1bvl C: [20284]
      Other proteins in same PDB: d1bvlb_, d1bvld_
      part of humanized anti-lysozyme Fv HuLys11
  6. Domain(s) for 1fgv:
  7. Domain(s) for 1fvc:
    1. 287206Domain d1fvcb_: 1fvc B: [19863]
      Other proteins in same PDB: d1fvca_, d1fvcc_
    2. 287207Domain d1fvcd_: 1fvc D: [19865]
      Other proteins in same PDB: d1fvca_, d1fvcc_
      part of humanized Fv 4D5, herceptin
  8. Domain(s) for 1fvd:
    1. 287211Domain d1fvdb1: 1fvd B:1-120 [19867]
      Other proteins in same PDB: d1fvda1, d1fvda2, d1fvdb2, d1fvdc1, d1fvdc2, d1fvdd2
    2. 287212Domain d1fvdd1: 1fvd D:1-120 [19869]
      Other proteins in same PDB: d1fvda1, d1fvda2, d1fvdb2, d1fvdc1, d1fvdc2, d1fvdd2
      part of humanized Fab 4D5, herceptin
  9. Domain(s) for 1fve:
    1. 287215Domain d1fveb1: 1fve B:1-120 [19871]
      Other proteins in same PDB: d1fvea1, d1fvea2, d1fveb2, d1fvec1, d1fvec2, d1fved2
    2. 287216Domain d1fved1: 1fve D:1-120 [19873]
      Other proteins in same PDB: d1fvea1, d1fvea2, d1fveb2, d1fvec1, d1fvec2, d1fved2
      part of humanized Fab 4D5, herceptin
  10. Domain(s) for 1gpo:
    1. 287203Domain d1gpoh1: 1gpo H:1-113 [20225]
      Other proteins in same PDB: d1gpoh2, d1gpoi2, d1gpol1, d1gpol2, d1gpom1, d1gpom2
    2. 287204Domain d1gpoi1: 1gpo I:1-113 [20227]
      Other proteins in same PDB: d1gpoh2, d1gpoi2, d1gpol1, d1gpol2, d1gpom1, d1gpom2
      part of Fab M41 (artificial design)
      complexed with so4
  11. Domain(s) for 1i9r:
    1. 287229Domain d1i9rh1: 1i9r H:1-118 [71151]
      Other proteins in same PDB: d1i9ra_, d1i9rb_, d1i9rc_, d1i9rh2, d1i9rk2, d1i9rl1, d1i9rl2, d1i9rm1, d1i9rm2, d1i9rx2, d1i9ry1, d1i9ry2
    2. 287230Domain d1i9rk1: 1i9r K:1-118 [71153]
      Other proteins in same PDB: d1i9ra_, d1i9rb_, d1i9rc_, d1i9rh2, d1i9rk2, d1i9rl1, d1i9rl2, d1i9rm1, d1i9rm2, d1i9rx2, d1i9ry1, d1i9ry2
    3. 287231Domain d1i9rx1: 1i9r X:1-118 [71159]
      Other proteins in same PDB: d1i9ra_, d1i9rb_, d1i9rc_, d1i9rh2, d1i9rk2, d1i9rl1, d1i9rl2, d1i9rm1, d1i9rm2, d1i9rx2, d1i9ry1, d1i9ry2
      complexed with zn
  12. Domain(s) for 1it9:
  13. Domain(s) for 1jps:
  14. Domain(s) for 1jpt:
  15. Domain(s) for 1l7i:
  16. Domain(s) for 1mhp:
    1. 287218Domain d1mhph1: 1mhp H:1-118 [84967]
      Other proteins in same PDB: d1mhpa_, d1mhpb_, d1mhph2, d1mhpl1, d1mhpl2, d1mhpy_
      part of humanized anti-alpha1 integrin I-domain Fab
      complexed with mn; mutant
    2. 287219Domain d1mhpx_: 1mhp X: [84971]
      Other proteins in same PDB: d1mhpa_, d1mhpb_, d1mhph2, d1mhpl1, d1mhpl2, d1mhpy_
      part of humanized anti-alpha1 integrin I-domain Fab; only V domain is ordered
      complexed with mn; mutant
  17. Domain(s) for 1n8z:
  18. Domain(s) for 1om3:
    1. 287209Domain d1om3h1: 1om3 H:1-115 [87059]
      Other proteins in same PDB: d1om3h2, d1om3k2, d1om3l1, d1om3l2, d1om3m1, d1om3m2
    2. 287210Domain d1om3k1: 1om3 K:1-115 [87061]
      Other proteins in same PDB: d1om3h2, d1om3k2, d1om3l1, d1om3l2, d1om3m1, d1om3m2
      part of engineered Fab 2G12
  19. Domain(s) for 1op3:
    1. 287201Domain d1op3h1: 1op3 H:1-115 [87208]
      Other proteins in same PDB: d1op3h2, d1op3k1, d1op3k2, d1op3l1, d1op3l2, d1op3m2
    2. 287202Domain d1op3m1: 1op3 M:1-115 [87214]
      Other proteins in same PDB: d1op3h2, d1op3k1, d1op3k2, d1op3l1, d1op3l2, d1op3m2
      part of engineered Fab 2G12
      complexed with box, man
  20. Domain(s) for 1op5:
    1. 287232Domain d1op5h1: 1op5 H:1-115 [87216]
      Other proteins in same PDB: d1op5h2, d1op5k1, d1op5k2, d1op5l1, d1op5l2, d1op5m2
    2. 287233Domain d1op5m1: 1op5 M:1-115 [87222]
      Other proteins in same PDB: d1op5h2, d1op5k1, d1op5k2, d1op5l1, d1op5l2, d1op5m2
      part of engineered Fab 2G12
      complexed with man, nag
  21. Domain(s) for 1vhp:
  22. Domain(s) for 2f5a:
  23. Domain(s) for 2f5b:
  24. Domain(s) for 2fgw:

More info for Species Engineered (including hybrid species) from b.1.1.1 Immunoglobulin heavy chain variable domain, VH

Timeline for Species Engineered (including hybrid species) from b.1.1.1 Immunoglobulin heavy chain variable domain, VH: