SCOP 1.73: Species: Human (Homo sapiens), cluster 3 [TaxId: 9606]

Lineage for Species: Human (Homo sapiens), cluster 3 [TaxId: 9606]

Root: SCOP 1.73
Class b: All beta proteins [48724] (165 folds)
Fold b.1: Immunoglobulin-like beta-sandwich [48725] (27 superfamilies)
sandwich; 7 strands in 2 sheets; greek-key
some members of the fold have additional strands
Superfamily b.1.1: Immunoglobulin [48726] (4 families)
Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (29 proteins)

Protein Immunoglobulin heavy chain variable domain, VH [88543] (20 species)
VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species

Species Human (Homo sapiens), cluster 3 [TaxId:9606] [88547] (19 PDB entries)

PDB entries in Species: Human (Homo sapiens), cluster 3 [TaxId: 9606]:

Domain(s) for 1adq:
- Domain d1adqh1: 1adq H:1-113 [20273]
  Other proteins in same PDB: d1adqa1, d1adqa2, d1adqh2, d1adql1, d1adql2
  part of IgM rheumatoid factor Fab
Domain(s) for 1aqk:
- Domain d1aqkh1: 1aqk H:1-123 [20193]
  Other proteins in same PDB: d1aqkh2, d1aqkl1, d1aqkl2
  part of Fab B7-15A2
Domain(s) for 1dee:
1. Domain d1deeb1: 1dee B:501-621 [20443]
  Other proteins in same PDB: d1deea1, d1deea2, d1deeb2, d1deec1, d1deec2, d1deed2, d1deee1, d1deee2, d1deef2, d1deeg_, d1deeh_
2. Domain d1deed1: 1dee D:1501-1621 [20445]
  Other proteins in same PDB: d1deea1, d1deea2, d1deeb2, d1deec1, d1deec2, d1deed2, d1deee1, d1deee2, d1deef2, d1deeg_, d1deeh_
3. Domain d1deef1: 1dee F:2501-2621 [20447]
  Other proteins in same PDB: d1deea1, d1deea2, d1deeb2, d1deec1, d1deec2, d1deed2, d1deee1, d1deee2, d1deef2, d1deeg_, d1deeh_
  part of IgM RF 2A2
Domain(s) for 1dfb:
- Domain d1dfbh1: 1dfb H:1-126 [19811]
  Other proteins in same PDB: d1dfbh2, d1dfbl1, d1dfbl2
  part of Fab 3D6
Domain(s) for 1dql:
- Domain d1dqlh_: 1dql H: [19829]
  Other proteins in same PDB: d1dqll_
  part of IgM Fv MEZ
Domain(s) for 1hez:
1. Domain d1hezb1: 1hez B:1-121 [60985]
  Other proteins in same PDB: d1heza1, d1heza2, d1hezb2, d1hezc1, d1hezc2, d1hezd2, d1heze_
2. Domain d1hezd1: 1hez D:1-121 [60989]
  Other proteins in same PDB: d1heza1, d1heza2, d1hezb2, d1hezc1, d1hezc2, d1hezd2, d1heze_
  part of IgM RF 2A2
  complexed with imd
Domain(s) for 1igm:
- Domain d1igmh_: 1igm H: [19827]
  Other proteins in same PDB: d1igml_
  part of IgM Fv POT
Domain(s) for 1nl0:
- Domain d1nl0h1: 1nl0 H:1-113 [91945]
  Other proteins in same PDB: d1nl0g_, d1nl0h2, d1nl0l1, d1nl0l2
  part of Fab 10c12 against factor IX Gla domain
  complexed with ca, so4
Domain(s) for 1u6a:
- Domain d1u6ah1: 1u6a H:2-113 [119564]
  Other proteins in same PDB: d1u6ah2, d1u6al1, d1u6al2
  automatically matched to d1aqkh1
Domain(s) for 1w72:
1. Domain d1w72h1: 1w72 H:1-113 [114299]
  Other proteins in same PDB: d1w72a1, d1w72a2, d1w72b_, d1w72d1, d1w72d2, d1w72e_, d1w72h2, d1w72i2, d1w72l1, d1w72l2, d1w72m1, d1w72m2
2. Domain d1w72i1: 1w72 I:1-113 [114301]
  Other proteins in same PDB: d1w72a1, d1w72a2, d1w72b_, d1w72d1, d1w72d2, d1w72e_, d1w72h2, d1w72i2, d1w72l1, d1w72l2, d1w72m1, d1w72m2
  complexed with gol

Domain(s) for 1y0l:

Domain d1y0lb1: 1y0l B:1-113 [122488]
Other proteins in same PDB: d1y0la1, d1y0la2, d1y0lb2, d1y0lc1, d1y0lc2, d1y0ld2, d1y0le1, d1y0le2, d1y0lf2, d1y0lh2, d1y0ll1, d1y0ll2
automatically matched to d1aqkh1
complexed with cl, han

Domain d1y0ld1: 1y0l D:1-113 [122492]
Other proteins in same PDB: d1y0la1, d1y0la2, d1y0lb2, d1y0lc1, d1y0lc2, d1y0ld2, d1y0le1, d1y0le2, d1y0lf2, d1y0lh2, d1y0ll1, d1y0ll2
automatically matched to d1aqkh1
complexed with cl, han

Domain d1y0lf1: 1y0l F:1-113 [122496]
Other proteins in same PDB: d1y0la1, d1y0la2, d1y0lb2, d1y0lc1, d1y0lc2, d1y0ld2, d1y0le1, d1y0le2, d1y0lf2, d1y0lh2, d1y0ll1, d1y0ll2
automatically matched to d1aqkh1
complexed with cl, han

Domain d1y0lh1: 1y0l H:1-113 [122498]
Other proteins in same PDB: d1y0la1, d1y0la2, d1y0lb2, d1y0lc1, d1y0lc2, d1y0ld2, d1y0le1, d1y0le2, d1y0lf2, d1y0lh2, d1y0ll1, d1y0ll2
automatically matched to d1aqkh1
complexed with cl, han

Domain(s) for 1y18:

Domain d1y18b1: 1y18 B:1-113 [122523]
Other proteins in same PDB: d1y18a1, d1y18a2, d1y18b2, d1y18c1, d1y18c2, d1y18d2, d1y18e1, d1y18e2, d1y18f2, d1y18h2, d1y18l1, d1y18l2
automatically matched to d1aqkh1
complexed with cl, han; mutant

Domain d1y18d1: 1y18 D:1-113 [122527]
Other proteins in same PDB: d1y18a1, d1y18a2, d1y18b2, d1y18c1, d1y18c2, d1y18d2, d1y18e1, d1y18e2, d1y18f2, d1y18h2, d1y18l1, d1y18l2
automatically matched to d1aqkh1
complexed with cl, han; mutant

Domain d1y18f1: 1y18 F:1-113 [122531]
Other proteins in same PDB: d1y18a1, d1y18a2, d1y18b2, d1y18c1, d1y18c2, d1y18d2, d1y18e1, d1y18e2, d1y18f2, d1y18h2, d1y18l1, d1y18l2
automatically matched to d1aqkh1
complexed with cl, han; mutant

Domain d1y18h1: 1y18 H:1-113 [122533]
Other proteins in same PDB: d1y18a1, d1y18a2, d1y18b2, d1y18c1, d1y18c2, d1y18d2, d1y18e1, d1y18e2, d1y18f2, d1y18h2, d1y18l1, d1y18l2
automatically matched to d1aqkh1
complexed with cl, han; mutant

Domain(s) for 1zls:
- Domain d1zlsh1: 1zls H:1-112 [125255]
  Other proteins in same PDB: d1zlsh2
  automatically matched to d1aqkh1
  complexed with man
Domain(s) for 1zlu:
1. Domain d1zluh1: 1zlu H:1-112 [125258]
  Other proteins in same PDB: d1zluh2, d1zlum2
  automatically matched to d1aqkh1
  complexed with man
2. Domain d1zlum1: 1zlu M:1-112 [125260]
  Other proteins in same PDB: d1zluh2, d1zlum2
  automatically matched to d1aqkh1
  complexed with man
Domain(s) for 1zlv:
1. Domain d1zlvh1: 1zlv H:1-112 [125262]
  Other proteins in same PDB: d1zlvh2, d1zlvm2
  automatically matched to d1aqkh1
  complexed with man
2. Domain d1zlvm1: 1zlv M:1-112 [125264]
  Other proteins in same PDB: d1zlvh2, d1zlvm2
  automatically matched to d1aqkh1
  complexed with man
Domain(s) for 1zlw:
1. Domain d1zlwh1: 1zlw H:1-112 [125266]
  Other proteins in same PDB: d1zlwh2, d1zlwm2
  automatically matched to d1aqkh1
  complexed with bma, man
2. Domain d1zlwm1: 1zlw M:1-112 [125268]
  Other proteins in same PDB: d1zlwh2, d1zlwm2
  automatically matched to d1aqkh1
  complexed with bma, man
Domain(s) for 2fb4:
- Domain d2fb4h1: 2fb4 H:1-119 [19847]
  Other proteins in same PDB: d2fb4h2, d2fb4l1, d2fb4l2
  part of Fab KOL
Domain(s) for 2ig2:
- Domain d2ig2h1: 2ig2 H:1-119 [19849]
  Other proteins in same PDB: d2ig2h2, d2ig2l1, d2ig2l2
  part of antibody KOL; intact protein but only Fab's can be seen in the crystal structure
Domain(s) for 8fab:
1. Domain d8fabb1: 8fab B:1-121 [19773]
  Other proteins in same PDB: d8faba1, d8faba2, d8fabb2, d8fabc1, d8fabc2, d8fabd2
2. Domain d8fabd1: 8fab D:1-121 [19775]
  Other proteins in same PDB: d8faba1, d8faba2, d8fabb2, d8fabc1, d8fabc2, d8fabd2
  part of Fab HIL

More info for Species Human (Homo sapiens), cluster 3 [TaxId:9606] from b.1.1.1 Immunoglobulin heavy chain variable domain, VH

Timeline for Species Human (Homo sapiens), cluster 3 [TaxId:9606] from b.1.1.1 Immunoglobulin heavy chain variable domain, VH:

Species Human (Homo sapiens), cluster 3 [TaxId:9606] from b.1.1.1 Immunoglobulin heavy chain variable domain, VH first appeared in SCOP 1.65
Species Human (Homo sapiens), cluster 3 [TaxId:9606] from b.1.1.1 Immunoglobulin heavy chain variable domain, VH appears in SCOP 1.71
Species Human (Homo sapiens), cluster 3 [TaxId:9606] from b.1.1.1 Immunoglobulin heavy chain variable domain, VH appears in SCOP 1.75
Species Human (Homo sapiens), cluster 3 [TaxId:9606] from b.1.1.1 Immunoglobulin heavy chain variable domain, VH appears in the current release, SCOPe 2.08