Lineage for Protein: Immunoglobulin light chain lambda variable domain, VL-lambda

  1. Root: SCOP 1.69
  2. 450777Class b: All beta proteins [48724] (144 folds)
  3. 450778Fold b.1: Immunoglobulin-like beta-sandwich [48725] (23 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 450779Superfamily b.1.1: Immunoglobulin [48726] (4 families) (S)
  5. 450780Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (27 proteins)
  6. 452262Protein Immunoglobulin light chain lambda variable domain, VL-lambda [88534] (9 species)
    VL-lambda domains of human antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the human genome; mouse VL-lambda domains belong to a single germline family

Species:

  1. 452263Hamster (Cricetulus griseus) [TaxId:10029] [88542] (1 PDB entry)
  2. 452266Human (Homo sapiens), cluster 1 [TaxId:9606] [88535] (4 PDB entries)
    1. Domains for 1cd0:
      1. 452269Domain d1cd0a_: 1cd0 A: [20559]
      2. 452270Domain d1cd0b_: 1cd0 B: [20560]
        VL dimer of Bence-Jones protein JTO
    2. Domains for 1pew:
      1. 452267Domain d1pewa_: 1pew A: [104135]
      2. 452268Domain d1pewb_: 1pew B: [104136]
    3. Domains for 1pw3:
      1. 452271Domain d1pw3a_: 1pw3 A: [104335]
      2. 452272Domain d1pw3b_: 1pw3 B: [104336]
    4. Domains for 2cd0:
      1. 452273Domain d2cd0a_: 2cd0 A: [20561]
      2. 452274Domain d2cd0b_: 2cd0 B: [20562]
        VL dimer of Bence-Jones protein WIL
  3. 452275Human (Homo sapiens), cluster 2 [TaxId:9606] [88536] (9 PDB entries)
    1. Domains for 1bjm:
      1. 452279Domain d1bjma1: 1bjm A:1-111 [20524]
        Other proteins in same PDB: d1bjma2, d1bjmb2
      2. 452280Domain d1bjmb1: 1bjm B:1-111 [20525]
        Other proteins in same PDB: d1bjma2, d1bjmb2
        VL dimer of Bence-Jones protein LOC
    2. Domain for 1nl0:
    3. Domains for 1q1j:
      1. 452286Domain d1q1jl1: 1q1j L:1-108 [95585]
        Other proteins in same PDB: d1q1jh1, d1q1jh2, d1q1ji1, d1q1ji2, d1q1jl2, d1q1jm2
      2. 452287Domain d1q1jm1: 1q1j M:1-108 [95587]
        Other proteins in same PDB: d1q1jh1, d1q1jh2, d1q1ji1, d1q1ji2, d1q1jl2, d1q1jm2
        part of anti HIV-1 Fab 447-52d
    4. Domain for 1rzf:
    5. Domain for 2fb4:
    6. Domain for 2ig2:
    7. Domain for 2rhe:
    8. Domains for 3bjl:
      1. 452282Domain d3bjla1: 3bjl A:1-111 [20526]
        Other proteins in same PDB: d3bjla2, d3bjlb2
      2. 452283Domain d3bjlb1: 3bjl B:1-111 [20527]
        Other proteins in same PDB: d3bjla2, d3bjlb2
        VL dimer of Bence-Jones protein LOC
    9. Domains for 4bjl:
      1. 452284Domain d4bjla1: 4bjl A:1-111 [20528]
        Other proteins in same PDB: d4bjla2, d4bjlb2
      2. 452285Domain d4bjlb1: 4bjl B:1-111 [20529]
        Other proteins in same PDB: d4bjla2, d4bjlb2
        VL dimer of Bence-Jones protein LOC
  4. 452289Human (Homo sapiens), cluster 3.1 [TaxId:9606] [88537] (1 PDB entry)
  5. 452291Human (Homo sapiens), cluster 3.2 [TaxId:9606] [88538] (1 PDB entry)
  6. 452293Human (Homo sapiens), cluster 4 [TaxId:9606] [88539] (23 PDB entries)
    1. Domains for 1a8j:
      1. 452332Domain d1a8jh1: 1a8j H:1-111 [20598]
        Other proteins in same PDB: d1a8jh2, d1a8jl2
        part of the antibody MCG light chain dimer
      2. 452333Domain d1a8jl1: 1a8j L:1-111 [20597]
        Other proteins in same PDB: d1a8jh2, d1a8jl2
    2. Domains for 1dcl:
      1. 452300Domain d1dcla1: 1dcl A:1-111 [20565]
        Other proteins in same PDB: d1dcla2, d1dclb2
      2. 452301Domain d1dclb1: 1dcl B:1-111 [20566]
        Other proteins in same PDB: d1dcla2, d1dclb2
        part of the antibody MCG light chain dimer
    3. Domains for 1jvk:
      1. 452296Domain d1jvka1: 1jvk A:1-112 [71897]
        Other proteins in same PDB: d1jvka2, d1jvkb2
      2. 452297Domain d1jvkb1: 1jvk B:1-112 [71899]
        Other proteins in same PDB: d1jvka2, d1jvkb2
        part of amyloidogenic protein BUR
    4. Domains for 1lgv:
      1. 452294Domain d1lgva1: 1lgv A:1-112 [84608]
        Other proteins in same PDB: d1lgva2, d1lgvb2
      2. 452295Domain d1lgvb1: 1lgv B:1-112 [84610]
        Other proteins in same PDB: d1lgva2, d1lgvb2
        part of amyloidogenic protein BUR
    5. Domains for 1lhz:
      1. 452298Domain d1lhza1: 1lhz A:1-112 [84612]
        Other proteins in same PDB: d1lhza2, d1lhzb2
      2. 452299Domain d1lhzb1: 1lhz B:1-112 [84614]
        Other proteins in same PDB: d1lhza2, d1lhzb2
        part of amyloidogenic protein BUR
    6. Domains for 1mcb:
      1. 452310Domain d1mcba1: 1mcb A:1-111 [20575]
        Other proteins in same PDB: d1mcba2, d1mcbb2
      2. 452311Domain d1mcbb1: 1mcb B:1-111 [20576]
        Other proteins in same PDB: d1mcba2, d1mcbb2
        part of the antibody MCG light chain dimer
    7. Domains for 1mcc:
      1. 452316Domain d1mcca1: 1mcc A:1-111 [20583]
        Other proteins in same PDB: d1mcca2, d1mccb2
      2. 452317Domain d1mccb1: 1mcc B:1-111 [20584]
        Other proteins in same PDB: d1mcca2, d1mccb2
        part of the antibody MCG light chain dimer
    8. Domains for 1mcd:
      1. 452306Domain d1mcda1: 1mcd A:1-111 [20571]
        Other proteins in same PDB: d1mcda2, d1mcdb2
      2. 452307Domain d1mcdb1: 1mcd B:1-111 [20572]
        Other proteins in same PDB: d1mcda2, d1mcdb2
        part of the antibody MCG light chain dimer
    9. Domains for 1mce:
      1. 452320Domain d1mcea1: 1mce A:1-111 [20587]
        Other proteins in same PDB: d1mcea2, d1mceb2
      2. 452321Domain d1mceb1: 1mce B:1-111 [20588]
        Other proteins in same PDB: d1mcea2, d1mceb2
        part of the antibody MCG light chain dimer
    10. Domains for 1mcf:
      1. 452312Domain d1mcfa1: 1mcf A:1-111 [20579]
        Other proteins in same PDB: d1mcfa2, d1mcfb2
      2. 452313Domain d1mcfb1: 1mcf B:1-111 [20580]
        Other proteins in same PDB: d1mcfa2, d1mcfb2
        part of the antibody MCG light chain dimer
    11. Domains for 1mch:
      1. 452334Domain d1mcha1: 1mch A:1-111 [20599]
        Other proteins in same PDB: d1mcha2, d1mchb2
      2. 452335Domain d1mchb1: 1mch B:1-111 [20600]
        Other proteins in same PDB: d1mcha2, d1mchb2
        part of the antibody MCG light chain dimer
    12. Domains for 1mci:
      1. 452318Domain d1mcia1: 1mci A:1-111 [20581]
        Other proteins in same PDB: d1mcia2, d1mcib2
      2. 452319Domain d1mcib1: 1mci B:1-111 [20582]
        Other proteins in same PDB: d1mcia2, d1mcib2
        part of the antibody MCG light chain dimer
    13. Domains for 1mcj:
      1. 452328Domain d1mcja1: 1mcj A:1-111 [20595]
        Other proteins in same PDB: d1mcja2, d1mcjb2
      2. 452329Domain d1mcjb1: 1mcj B:1-111 [20596]
        Other proteins in same PDB: d1mcja2, d1mcjb2
        part of the antibody MCG light chain dimer
    14. Domains for 1mck:
      1. 452308Domain d1mcka1: 1mck A:1-111 [20573]
        Other proteins in same PDB: d1mcka2, d1mckb2
      2. 452309Domain d1mckb1: 1mck B:1-111 [20574]
        Other proteins in same PDB: d1mcka2, d1mckb2
        part of the antibody MCG light chain dimer
    15. Domains for 1mcl:
      1. 452322Domain d1mcla1: 1mcl A:1-111 [20589]
        Other proteins in same PDB: d1mcla2, d1mclb2
      2. 452323Domain d1mclb1: 1mcl B:1-111 [20590]
        Other proteins in same PDB: d1mcla2, d1mclb2
        part of the antibody MCG light chain dimer
    16. Domains for 1mcn:
      1. 452326Domain d1mcna1: 1mcn A:1-111 [20591]
        Other proteins in same PDB: d1mcna2, d1mcnb2
      2. 452327Domain d1mcnb1: 1mcn B:1-111 [20592]
        Other proteins in same PDB: d1mcna2, d1mcnb2
        part of the antibody MCG light chain dimer
    17. Domain for 1mco:
    18. Domains for 1mcq:
      1. 452314Domain d1mcqa1: 1mcq A:1-111 [20577]
        Other proteins in same PDB: d1mcqa2, d1mcqb2
      2. 452315Domain d1mcqb1: 1mcq B:1-111 [20578]
        Other proteins in same PDB: d1mcqa2, d1mcqb2
        part of the antibody MCG light chain dimer
    19. Domains for 1mcr:
      1. 452330Domain d1mcra1: 1mcr A:1-111 [20593]
        Other proteins in same PDB: d1mcra2, d1mcrb2
      2. 452331Domain d1mcrb1: 1mcr B:1-111 [20594]
        Other proteins in same PDB: d1mcra2, d1mcrb2
        part of the antibody MCG light chain dimer
    20. Domains for 1mcs:
      1. 452324Domain d1mcsa1: 1mcs A:1-111 [20585]
        Other proteins in same PDB: d1mcsa2, d1mcsb2
      2. 452325Domain d1mcsb1: 1mcs B:1-111 [20586]
        Other proteins in same PDB: d1mcsa2, d1mcsb2
        part of the antibody MCG light chain dimer
    21. Domains for 1mcw:
      1. 452336Domain d1mcwm1: 1mcw M:1-111 [20601]
        Other proteins in same PDB: d1mcwm2, d1mcww2
      2. 452337Domain d1mcww1: 1mcw W:1-111 [20602]
        Other proteins in same PDB: d1mcwm2, d1mcww2
        part of heterologous L chain dimer MCG-WEIR
    22. Domains for 2mcg:
      1. 452302Domain d2mcg11: 2mcg 1:1-111 [20567]
        Other proteins in same PDB: d2mcg12, d2mcg22
      2. 452303Domain d2mcg21: 2mcg 2:1-111 [20568]
        Other proteins in same PDB: d2mcg12, d2mcg22
        part of the antibody MCG light chain dimer
    23. Domains for 3mcg:
      1. 452304Domain d3mcg11: 3mcg 1:1-111 [20569]
        Other proteins in same PDB: d3mcg12, d3mcg22
      2. 452305Domain d3mcg21: 3mcg 2:1-111 [20570]
        Other proteins in same PDB: d3mcg12, d3mcg22
        part of the antibody MCG light chain dimer
  7. 452339Human (Homo sapiens), cluster 5 [TaxId:9606] [88540] (3 PDB entries)
    1. Domain for 1adq:
    2. Domains for 1lil:
      1. 452342Domain d1lila1: 1lil A:2-107 [20557]
        Other proteins in same PDB: d1lila2, d1lilb2
      2. 452343Domain d1lilb1: 1lil B:2-107 [20558]
        Other proteins in same PDB: d1lila2, d1lilb2
        part of Bence-Jones protein CLE
    3. Domains for 8fab:
      1. 452340Domain d8faba1: 8fab A:3-105 [19772]
        Other proteins in same PDB: d8faba2, d8fabb1, d8fabb2, d8fabc2, d8fabd1, d8fabd2
      2. 452341Domain d8fabc1: 8fab C:3-105 [19774]
        Other proteins in same PDB: d8faba2, d8fabb1, d8fabb2, d8fabc2, d8fabd1, d8fabd2
        part of Fab HIL
  8. 452345Mouse (Mus musculus) [TaxId:10090] [88541] (33 PDB entries)
    1. Domain for 1a6u:
    2. Domains for 1a6v:
      1. 452362Domain d1a6vl_: 1a6v L: [20256]
        Other proteins in same PDB: d1a6vh_, d1a6vi_, d1a6vj_
      2. 452363Domain d1a6vm_: 1a6v M: [20258]
        Other proteins in same PDB: d1a6vh_, d1a6vi_, d1a6vj_
      3. 452364Domain d1a6vn_: 1a6v N: [20260]
        Other proteins in same PDB: d1a6vh_, d1a6vi_, d1a6vj_
        part of Fv B1-8
    3. Domain for 1a6w:
    4. Domain for 1dl7:
      • 452373Domain d1dl7l_: 1dl7 L: [20498]
        Other proteins in same PDB: d1dl7h_
        part of Fv M3C65; conflict: annotated in PDB as human protein
    5. Domains for 1etz:
      1. 452382Domain d1etza1: 1etz A:1-110 [20480]
        Other proteins in same PDB: d1etza2, d1etzb1, d1etzb2, d1etzh1, d1etzh2, d1etzl2
        part of anti-sweetener Fab NC10.14
      2. 452383Domain d1etzl1: 1etz L:1-110 [20478]
        Other proteins in same PDB: d1etza2, d1etzb1, d1etzb2, d1etzh1, d1etzh2, d1etzl2
    6. Domain for 1f4w:
    7. Domain for 1f4x:
    8. Domain for 1f4y:
    9. Domain for 1gig:
    10. Domain for 1ind:
    11. Domain for 1ine:
    12. Domain for 1jn6:
    13. Domains for 1jnh:
      1. 452374Domain d1jnha1: 1jnh A:1-108 [66939]
        Other proteins in same PDB: d1jnha2, d1jnhb1, d1jnhb2, d1jnhc2, d1jnhd1, d1jnhd2, d1jnhe2, d1jnhf1, d1jnhf2, d1jnhg2, d1jnhh1, d1jnhh2
      2. 452375Domain d1jnhc1: 1jnh C:1-108 [66943]
        Other proteins in same PDB: d1jnha2, d1jnhb1, d1jnhb2, d1jnhc2, d1jnhd1, d1jnhd2, d1jnhe2, d1jnhf1, d1jnhf2, d1jnhg2, d1jnhh1, d1jnhh2
      3. 452376Domain d1jnhe1: 1jnh E:1-108 [66947]
        Other proteins in same PDB: d1jnha2, d1jnhb1, d1jnhb2, d1jnhc2, d1jnhd1, d1jnhd2, d1jnhe2, d1jnhf1, d1jnhf2, d1jnhg2, d1jnhh1, d1jnhh2
      4. 452377Domain d1jnhg1: 1jnh G:1-108 [66951]
        Other proteins in same PDB: d1jnha2, d1jnhb1, d1jnhb2, d1jnhc2, d1jnhd1, d1jnhd2, d1jnhe2, d1jnhf1, d1jnhf2, d1jnhg2, d1jnhh1, d1jnhh2
        part of anti-estradiol Fab 10G6D6
    14. Domain for 1mfa:
    15. Domain for 1mfb:
    16. Domain for 1mfc:
    17. Domain for 1mfd:
    18. Domain for 1mfe:
    19. Domains for 1nc2:
      1. 452356Domain d1nc2a1: 1nc2 A:1-110 [91781]
        Other proteins in same PDB: d1nc2a2, d1nc2b1, d1nc2b2, d1nc2c2, d1nc2d1, d1nc2d2
      2. 452357Domain d1nc2c1: 1nc2 C:1-110 [91785]
        Other proteins in same PDB: d1nc2a2, d1nc2b1, d1nc2b2, d1nc2c2, d1nc2d1, d1nc2d2
        part of Fab 2d12.5
    20. Domains for 1nc4:
      1. 452359Domain d1nc4a1: 1nc4 A:1-110 [91789]
        Other proteins in same PDB: d1nc4a2, d1nc4b1, d1nc4b2, d1nc4c2, d1nc4d1, d1nc4d2
      2. 452360Domain d1nc4c1: 1nc4 C:1-110 [91793]
        Other proteins in same PDB: d1nc4a2, d1nc4b1, d1nc4b2, d1nc4c2, d1nc4d1, d1nc4d2
        part of Fab 2d12.5
    21. Domain for 1ngp:
    22. Domain for 1ngq:
    23. Domains for 1nj9:
      1. 452370Domain d1nj9a1: 1nj9 A:1-108 [91897]
        Other proteins in same PDB: d1nj9a2, d1nj9b1, d1nj9b2, d1nj9h1, d1nj9h2, d1nj9l2
      2. 452371Domain d1nj9l1: 1nj9 L:1-108 [91903]
        Other proteins in same PDB: d1nj9a2, d1nj9b1, d1nj9b2, d1nj9h1, d1nj9h2, d1nj9l2
        part of cocaine hydrolytic Fab 15a10
    24. Domain for 1p4b:
    25. Domain for 1p4i:
    26. Domains for 1pg7:
      1. 452387Domain d1pg7w1: 1pg7 W:1-108 [94682]
        Other proteins in same PDB: d1pg7h1, d1pg7h2, d1pg7i1, d1pg7i2, d1pg7l1, d1pg7l2, d1pg7m1, d1pg7m2, d1pg7w2, d1pg7x1, d1pg7x2, d1pg7y2, d1pg7z1, d1pg7z2
      2. 452388Domain d1pg7y1: 1pg7 Y:1-108 [94686]
        Other proteins in same PDB: d1pg7h1, d1pg7h2, d1pg7i1, d1pg7i2, d1pg7l1, d1pg7l2, d1pg7m1, d1pg7m2, d1pg7w2, d1pg7x1, d1pg7x2, d1pg7y2, d1pg7z1, d1pg7z2
        part of Fab 6A6
    27. Domain for 1q0x:
    28. Domain for 1q0y:
    29. Domain for 1sm3:
    30. Domains for 1yuh:
      1. 452385Domain d1yuha1: 1yuh A:2-109 [20098]
        Other proteins in same PDB: d1yuha2, d1yuhb1, d1yuhb2, d1yuhh1, d1yuhh2, d1yuhl2
        part of an anti-nitrophenol Fab
      2. 452386Domain d1yuhl1: 1yuh L:2-109 [20096]
        Other proteins in same PDB: d1yuha2, d1yuhb1, d1yuhb2, d1yuhh1, d1yuhh2, d1yuhl2
    31. Domain for 2vir:
    32. Domain for 2vis:
    33. Domain for 2vit:
  9. 452390Rat (Rattus norvegicus) [TaxId:10116] [101504] (7 PDB entries)
    1. Domain for 1oaq:
    2. Domains for 1oar:
      1. 452396Domain d1oarl_: 1oar L: [92713]
        Other proteins in same PDB: d1oarh_, d1oari_, d1oarj_, d1oark_
      2. 452397Domain d1oarm_: 1oar M: [92714]
        Other proteins in same PDB: d1oarh_, d1oari_, d1oarj_, d1oark_
      3. 452398Domain d1oarn_: 1oar N: [92715]
        Other proteins in same PDB: d1oarh_, d1oari_, d1oarj_, d1oark_
      4. 452399Domain d1oaro_: 1oar O: [92716]
        Other proteins in same PDB: d1oarh_, d1oari_, d1oarj_, d1oark_
        part of IgE Fv spe-7
    3. Domains for 1oau:
      1. 452392Domain d1oaul_: 1oau L: [92721]
        Other proteins in same PDB: d1oauh_, d1oaui_, d1oauj_, d1oauk_
      2. 452393Domain d1oaum_: 1oau M: [92722]
        Other proteins in same PDB: d1oauh_, d1oaui_, d1oauj_, d1oauk_
      3. 452394Domain d1oaun_: 1oau N: [92723]
        Other proteins in same PDB: d1oauh_, d1oaui_, d1oauj_, d1oauk_
      4. 452395Domain d1oauo_: 1oau O: [92724]
        Other proteins in same PDB: d1oauh_, d1oaui_, d1oauj_, d1oauk_
        part of IgE Fv spe-7
    4. Domains for 1oax:
      1. 452401Domain d1oaxl_: 1oax L: [92729]
        Other proteins in same PDB: d1oaxh_, d1oaxi_, d1oaxj_, d1oaxk_
      2. 452402Domain d1oaxm_: 1oax M: [92730]
        Other proteins in same PDB: d1oaxh_, d1oaxi_, d1oaxj_, d1oaxk_
      3. 452403Domain d1oaxn_: 1oax N: [92731]
        Other proteins in same PDB: d1oaxh_, d1oaxi_, d1oaxj_, d1oaxk_
      4. 452404Domain d1oaxo_: 1oax O: [92732]
        Other proteins in same PDB: d1oaxh_, d1oaxi_, d1oaxj_, d1oaxk_
        part of IgE Fv spe-7
    5. Domains for 1oay:
      1. 452405Domain d1oayl_: 1oay L: [92737]
        Other proteins in same PDB: d1oayh_, d1oayi_, d1oayj_, d1oayk_
      2. 452406Domain d1oaym_: 1oay M: [92738]
        Other proteins in same PDB: d1oayh_, d1oayi_, d1oayj_, d1oayk_
      3. 452407Domain d1oayn_: 1oay N: [92739]
        Other proteins in same PDB: d1oayh_, d1oayi_, d1oayj_, d1oayk_
      4. 452408Domain d1oayo_: 1oay O: [92740]
        Other proteins in same PDB: d1oayh_, d1oayi_, d1oayj_, d1oayk_
        part of IgE Fv spe-7
    6. Domains for 1oaz:
      1. 452409Domain d1oazl_: 1oaz L: [92745]
        Other proteins in same PDB: d1oaza_, d1oazb_, d1oazh_, d1oazj_
      2. 452410Domain d1oazn_: 1oaz N: [92746]
        Other proteins in same PDB: d1oaza_, d1oazb_, d1oazh_, d1oazj_
        part of IgE Fv spe-7
    7. Domain for 1ocw:

More info for Protein Immunoglobulin light chain lambda variable domain, VL-lambda from b.1.1.1: V set domains (antibody variable domain-like)

Timeline for Protein Immunoglobulin light chain lambda variable domain, VL-lambda from b.1.1.1: V set domains (antibody variable domain-like):

  • Protein Immunoglobulin light chain lambda variable domain, VL-lambda from b.1.1.1: V set domains (antibody variable domain-like) first appeared in SCOP 1.65
  • Protein Immunoglobulin light chain lambda variable domain, VL-lambda from b.1.1.1: V set domains (antibody variable domain-like) appears in SCOP 1.67
  • Protein Immunoglobulin light chain lambda variable domain, VL-lambda from b.1.1.1: V set domains (antibody variable domain-like) appears in SCOP 1.71
  • Protein Immunoglobulin light chain lambda variable domain, VL-lambda from b.1.1.1: V set domains (antibody variable domain-like) appears in the current release, SCOPe 2.07