Lineage for Species: Engineered (including hybrid species)

  1. Root: SCOPe 2.06
  2. 2021373Class b: All beta proteins [48724] (177 folds)
  3. 2021374Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 2021375Superfamily b.1.1: Immunoglobulin [48726] (5 families) (S)
  5. 2021376Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 proteins)
  6. 2022563Protein Immunoglobulin light chain kappa variable domain, VL-kappa [88519] (16 species)
    VL-kappa domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VL-kappa domains with artificial or grafted exogenous CDRs are listed as engineered species
  7. 2022564Species Engineered (including hybrid species) [88533] (61 PDB entries)
    SQ NA # humanized antidoby; bactericidal Fab-h6831 ! SQ NA # Humanized antibody ! SQ NA # humanized antibody ! SQ NA # engineered antibody

PDB entries in Species: Engineered (including hybrid species):

  1. Domain(s) for 1ad0:
    1. 2022605Domain d1ad0a1: 1ad0 A:1-107 [20124]
      Other proteins in same PDB: d1ad0a2, d1ad0b1, d1ad0b2, d1ad0c2, d1ad0d1, d1ad0d2
      part of humanized Fab A5B7
    2. 2022606Domain d1ad0c1: 1ad0 C:1-107 [20126]
      Other proteins in same PDB: d1ad0a2, d1ad0b1, d1ad0b2, d1ad0c2, d1ad0d1, d1ad0d2
      part of humanized Fab A5B7
  2. Domain(s) for 1ad9:
    1. 2022620Domain d1ad9a1: 1ad9 A:1-107 [20214]
      Other proteins in same PDB: d1ad9a2, d1ad9b1, d1ad9b2, d1ad9h1, d1ad9h2, d1ad9l2
      part of humanized Fab CTM01
      complexed with so4
    2. 2022621Domain d1ad9l1: 1ad9 L:1-107 [20212]
      Other proteins in same PDB: d1ad9a2, d1ad9b1, d1ad9b2, d1ad9h1, d1ad9h2, d1ad9l2
      part of humanized Fab CTM01
      complexed with so4
  3. Domain(s) for 1b2w:
  4. Domain(s) for 1bvk:
    1. 2022625Domain d1bvka_: 1bvk A: [20278]
      Other proteins in same PDB: d1bvkb_, d1bvkc_, d1bvke_, d1bvkf_
      part of humanized anti-lysozyme Fv HuLys11
    2. 2022626Domain d1bvkd_: 1bvk D: [20280]
      Other proteins in same PDB: d1bvkb_, d1bvkc_, d1bvke_, d1bvkf_
      part of humanized anti-lysozyme Fv HuLys11
  5. Domain(s) for 1bvl:
    1. 2022634Domain d1bvlb_: 1bvl B: [20283]
      Other proteins in same PDB: d1bvla_, d1bvlc_
      part of humanized anti-lysozyme Fv HuLys11
    2. 2022635Domain d1bvld_: 1bvl D: [20285]
      Other proteins in same PDB: d1bvla_, d1bvlc_
      part of humanized anti-lysozyme Fv HuLys11
  6. Domain(s) for 1fgv:
  7. Domain(s) for 1fvc:
    1. 2022586Domain d1fvca_: 1fvc A: [19862]
      Other proteins in same PDB: d1fvcb_, d1fvcd_
      part of humanized Fv 4D5, herceptin
    2. 2022587Domain d1fvcc_: 1fvc C: [19864]
      Other proteins in same PDB: d1fvcb_, d1fvcd_
      part of humanized Fv 4D5, herceptin
  8. Domain(s) for 1fvd:
    1. 2022603Domain d1fvda1: 1fvd A:1-107 [19866]
      Other proteins in same PDB: d1fvda2, d1fvdb1, d1fvdb2, d1fvdc2, d1fvdd1, d1fvdd2
      part of humanized Fab 4D5, herceptin
    2. 2022604Domain d1fvdc1: 1fvd C:1-107 [19868]
      Other proteins in same PDB: d1fvda2, d1fvdb1, d1fvdb2, d1fvdc2, d1fvdd1, d1fvdd2
      part of humanized Fab 4D5, herceptin
  9. Domain(s) for 1fve:
    1. 2022613Domain d1fvea1: 1fve A:1-107 [19870]
      Other proteins in same PDB: d1fvea2, d1fveb1, d1fveb2, d1fvec2, d1fved1, d1fved2
      part of humanized Fab 4D5, herceptin
    2. 2022614Domain d1fvec1: 1fve C:1-107 [19872]
      Other proteins in same PDB: d1fvea2, d1fveb1, d1fveb2, d1fvec2, d1fved1, d1fved2
      part of humanized Fab 4D5, herceptin
  10. Domain(s) for 1gpo:
    1. 2022578Domain d1gpol1: 1gpo L:1-112 [20224]
      Other proteins in same PDB: d1gpoh1, d1gpoh2, d1gpoi1, d1gpoi2, d1gpol2, d1gpom2
      complexed with so4
    2. 2022579Domain d1gpom1: 1gpo M:1-112 [20226]
      Other proteins in same PDB: d1gpoh1, d1gpoh2, d1gpoi1, d1gpoi2, d1gpol2, d1gpom2
      complexed with so4
  11. Domain(s) for 1i9r:
    1. 2022636Domain d1i9rl1: 1i9r L:1-111 [71155]
      Other proteins in same PDB: d1i9ra_, d1i9rb_, d1i9rc_, d1i9rh1, d1i9rh2, d1i9rk1, d1i9rk2, d1i9rl2, d1i9rm2, d1i9rx1, d1i9rx2, d1i9ry2
      part of humanized Fab 5C8 against C40 ligand
      complexed with zn
    2. 2022637Domain d1i9rm1: 1i9r M:1-111 [71157]
      Other proteins in same PDB: d1i9ra_, d1i9rb_, d1i9rc_, d1i9rh1, d1i9rh2, d1i9rk1, d1i9rk2, d1i9rl2, d1i9rm2, d1i9rx1, d1i9rx2, d1i9ry2
      part of humanized Fab 5C8 against C40 ligand
      complexed with zn
    3. 2022638Domain d1i9ry1: 1i9r Y:1-111 [71161]
      Other proteins in same PDB: d1i9ra_, d1i9rb_, d1i9rc_, d1i9rh1, d1i9rh2, d1i9rk1, d1i9rk2, d1i9rl2, d1i9rm2, d1i9rx1, d1i9rx2, d1i9ry2
      part of humanized Fab 5C8 against C40 ligand
      complexed with zn
  12. Domain(s) for 1it9:
  13. Domain(s) for 1ivl:
    1. 2022601Domain d1ivla_: 1ivl A: [20516]
      VL domain of synthetic antibody M29B; "reversed" dimerisation mode
      complexed with ipa
    2. 2022602Domain d1ivlb_: 1ivl B: [20517]
      VL domain of synthetic antibody M29B; "reversed" dimerisation mode
      complexed with ipa
  14. Domain(s) for 1jps:
  15. Domain(s) for 1jpt:
  16. Domain(s) for 1jv5:
  17. Domain(s) for 1l7i:
  18. Domain(s) for 1mhp:
    1. 2022617Domain d1mhpl1: 1mhp L:2-106 [84969]
      Other proteins in same PDB: d1mhpa_, d1mhpb_, d1mhph1, d1mhph2, d1mhpl2, d1mhpx_
      part of humanized anti-alpha1 integrin I-domain Fab
      complexed with mn
    2. 2022618Domain d1mhpy_: 1mhp Y: [84972]
      Other proteins in same PDB: d1mhpa_, d1mhpb_, d1mhph1, d1mhph2, d1mhpl2, d1mhpx_
      part of humanized anti-alpha1 integrin I-domain Fab; only V domain is ordered
      complexed with mn
  19. Domain(s) for 1n8z:
  20. Domain(s) for 1om3:
    1. 2022593Domain d1om3l1: 1om3 L:2-107 [87063]
      Other proteins in same PDB: d1om3h1, d1om3h2, d1om3k1, d1om3k2, d1om3l2, d1om3m2
      part of engineered Fab 2G12
    2. 2022594Domain d1om3m1: 1om3 M:2-107 [87065]
      Other proteins in same PDB: d1om3h1, d1om3h2, d1om3k1, d1om3k2, d1om3l2, d1om3m2
      part of engineered Fab 2G12
  21. Domain(s) for 1op3:
    1. 2022571Domain d1op3k1: 1op3 K:2-107 [87210]
      Other proteins in same PDB: d1op3h1, d1op3h2, d1op3k2, d1op3l2, d1op3m1, d1op3m2
      part of engineered Fab 2G12
      complexed with bez, man
    2. 2022572Domain d1op3l1: 1op3 L:2-107 [87212]
      Other proteins in same PDB: d1op3h1, d1op3h2, d1op3k2, d1op3l2, d1op3m1, d1op3m2
      part of engineered Fab 2G12
      complexed with bez, man
  22. Domain(s) for 1op5:
    1. 2022639Domain d1op5k1: 1op5 K:2-107 [87218]
      Other proteins in same PDB: d1op5h1, d1op5h2, d1op5k2, d1op5l2, d1op5m1, d1op5m2
      part of engineered Fab 2G12
      complexed with man
    2. 2022640Domain d1op5l1: 1op5 L:2-107 [87220]
      Other proteins in same PDB: d1op5h1, d1op5h2, d1op5k2, d1op5l2, d1op5m1, d1op5m2
      part of engineered Fab 2G12
      complexed with man
  23. Domain(s) for 1pg7:
    1. 2022623Domain d1pg7l1: 1pg7 L:1-107 [94678]
      Other proteins in same PDB: d1pg7h1, d1pg7h2, d1pg7i1, d1pg7i2, d1pg7l2, d1pg7m2, d1pg7w1, d1pg7w2, d1pg7x1, d1pg7x2, d1pg7y1, d1pg7y2, d1pg7z1, d1pg7z2
      part of humanized Fab D3H44 against human tissue factor
    2. 2022624Domain d1pg7m1: 1pg7 M:1-107 [94680]
      Other proteins in same PDB: d1pg7h1, d1pg7h2, d1pg7i1, d1pg7i2, d1pg7l2, d1pg7m2, d1pg7w1, d1pg7w2, d1pg7x1, d1pg7x2, d1pg7y1, d1pg7y2, d1pg7z1, d1pg7z2
      part of humanized Fab D3H44 against human tissue factor
  24. Domain(s) for 1rjl:
  25. Domain(s) for 1s3k:
  26. Domain(s) for 1s78:
    1. 2022641Domain d1s78c1: 1s78 C:1-107 [98624]
      Other proteins in same PDB: d1s78a1, d1s78a2, d1s78a3, d1s78a4, d1s78b1, d1s78b2, d1s78b3, d1s78b4, d1s78c2, d1s78d1, d1s78d2, d1s78e2, d1s78f1, d1s78f2
      part of anti-ERBb2 Fab Pertuzumab
      complexed with nag
    2. 2022642Domain d1s78e1: 1s78 E:1-107 [98628]
      Other proteins in same PDB: d1s78a1, d1s78a2, d1s78a3, d1s78a4, d1s78b1, d1s78b2, d1s78b3, d1s78b4, d1s78c2, d1s78d1, d1s78d2, d1s78e2, d1s78f1, d1s78f2
      part of anti-ERBb2 Fab Pertuzumab
      complexed with nag
  27. Domain(s) for 1t04:
    1. 2022631Domain d1t04a1: 1t04 A:1-108 [112182]
      Other proteins in same PDB: d1t04a2, d1t04b1, d1t04b2, d1t04c2, d1t04d1, d1t04d2
    2. 2022632Domain d1t04c1: 1t04 C:1-108 [112186]
      Other proteins in same PDB: d1t04a2, d1t04b1, d1t04b2, d1t04c2, d1t04d1, d1t04d2
  28. Domain(s) for 1t3f:
  29. Domain(s) for 1tjg:
  30. Domain(s) for 1tjh:
  31. Domain(s) for 1tji:
  32. Domain(s) for 1tzh:
    1. 2022615Domain d1tzha1: 1tzh A:1-107 [107477]
      Other proteins in same PDB: d1tzha2, d1tzhb1, d1tzhb2, d1tzhh1, d1tzhh2, d1tzhl2, d1tzhv_, d1tzhw_
    2. 2022616Domain d1tzhl1: 1tzh L:1-107 [107483]
      Other proteins in same PDB: d1tzha2, d1tzhb1, d1tzhb2, d1tzhh1, d1tzhh2, d1tzhl2, d1tzhv_, d1tzhw_
  33. Domain(s) for 1tzi:
  34. Domain(s) for 1u8h:
  35. Domain(s) for 1u8i:
  36. Domain(s) for 1u8j:
  37. Domain(s) for 1u8k:
  38. Domain(s) for 1u8l:
  39. Domain(s) for 1u8m:
  40. Domain(s) for 1u8n:
  41. Domain(s) for 1u8o:
  42. Domain(s) for 1u8p:
  43. Domain(s) for 1u8q:
  44. Domain(s) for 1u91:
  45. Domain(s) for 1u92:
  46. Domain(s) for 1u93:
  47. Domain(s) for 1u95:
  48. Domain(s) for 1uj3:
  49. Domain(s) for 2f5a:
  50. Domain(s) for 2f5b:
  51. Domain(s) for 2fgw:
  52. Domain(s) for 2imn:
    • 2022566Domain d2imna_: 2imn A: [19856]
      VL domain only of humanized antibody MCPC603
      complexed with act, so4; mutant
  53. Domain(s) for 2pr4:
  54. Domain(s) for 3eyv:
    1. 2022608Domain d3eyvb1: 3eyv B:1-119 [209745]
      Other proteins in same PDB: d3eyva2, d3eyvb2, d3eyvh2, d3eyvl2
      automated match to d1s3kh1
      complexed with gol, zn
    2. 2022609Domain d3eyvh1: 3eyv H:1-119 [209747]
      Other proteins in same PDB: d3eyva2, d3eyvb2, d3eyvh2, d3eyvl2
      automated match to d1s3kh1
      complexed with gol, zn
  55. Domain(s) for 3idg:
  56. Domain(s) for 3idi:
  57. Domain(s) for 3idj:
  58. Domain(s) for 3idm:
  59. Domain(s) for 3idn:
  60. Domain(s) for 3lev:
  61. Domain(s) for 3oau:

More info for Species Engineered (including hybrid species) from b.1.1.1 Immunoglobulin light chain kappa variable domain, VL-kappa

Timeline for Species Engineered (including hybrid species) from b.1.1.1 Immunoglobulin light chain kappa variable domain, VL-kappa: