Lineage for Species: Engineered (including hybrid species)

  1. Root: SCOPe 2.03
  2. 1287432Class b: All beta proteins [48724] (174 folds)
  3. 1287433Fold b.1: Immunoglobulin-like beta-sandwich [48725] (28 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 1287434Superfamily b.1.1: Immunoglobulin [48726] (5 families) (S)
  5. 1287435Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 proteins)
  6. 1288590Protein Immunoglobulin light chain kappa variable domain, VL-kappa [88519] (16 species)
    VL-kappa domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VL-kappa domains with artificial or grafted exogenous CDRs are listed as engineered species
  7. 1288591Species Engineered (including hybrid species) [88533] (61 PDB entries)
    SQ NA # humanized antidoby; bactericidal Fab-h6831 ! SQ NA # Humanized antibody ! SQ NA # humanized antibody ! SQ NA # engineered antibody

PDB entries in Species: Engineered (including hybrid species):

  1. Domain(s) for 1ad0:
    1. 1288632Domain d1ad0a1: 1ad0 A:1-107 [20124]
      Other proteins in same PDB: d1ad0a2, d1ad0b1, d1ad0b2, d1ad0c2, d1ad0d1, d1ad0d2
      part of humanized Fab A5B7
    2. 1288633Domain d1ad0c1: 1ad0 C:1-107 [20126]
      Other proteins in same PDB: d1ad0a2, d1ad0b1, d1ad0b2, d1ad0c2, d1ad0d1, d1ad0d2
      part of humanized Fab A5B7
  2. Domain(s) for 1ad9:
    1. 1288651Domain d1ad9a1: 1ad9 A:1-107 [20214]
      Other proteins in same PDB: d1ad9a2, d1ad9b1, d1ad9b2, d1ad9h1, d1ad9h2, d1ad9l2
      part of humanized Fab CTM01
      complexed with so4
    2. 1288652Domain d1ad9l1: 1ad9 L:1-107 [20212]
      Other proteins in same PDB: d1ad9a2, d1ad9b1, d1ad9b2, d1ad9h1, d1ad9h2, d1ad9l2
      part of humanized Fab CTM01
      complexed with so4
  3. Domain(s) for 1b2w:
  4. Domain(s) for 1bvk:
    1. 1288654Domain d1bvka_: 1bvk A: [20278]
      Other proteins in same PDB: d1bvkb_, d1bvkc_, d1bvke_, d1bvkf_
      part of humanized anti-lysozyme Fv HuLys11
    2. 1288655Domain d1bvkd_: 1bvk D: [20280]
      Other proteins in same PDB: d1bvkb_, d1bvkc_, d1bvke_, d1bvkf_
      part of humanized anti-lysozyme Fv HuLys11
  5. Domain(s) for 1bvl:
    1. 1288661Domain d1bvlb_: 1bvl B: [20283]
      Other proteins in same PDB: d1bvla_, d1bvlc_
      part of humanized anti-lysozyme Fv HuLys11
    2. 1288662Domain d1bvld_: 1bvl D: [20285]
      Other proteins in same PDB: d1bvla_, d1bvlc_
      part of humanized anti-lysozyme Fv HuLys11
  6. Domain(s) for 1fgv:
  7. Domain(s) for 1fvc:
    1. 1288615Domain d1fvca_: 1fvc A: [19862]
      Other proteins in same PDB: d1fvcb_, d1fvcd_
      part of humanized Fv 4D5, herceptin
    2. 1288616Domain d1fvcc_: 1fvc C: [19864]
      Other proteins in same PDB: d1fvcb_, d1fvcd_
      part of humanized Fv 4D5, herceptin
  8. Domain(s) for 1fvd:
    1. 1288630Domain d1fvda1: 1fvd A:1-107 [19866]
      Other proteins in same PDB: d1fvda2, d1fvdb1, d1fvdb2, d1fvdc2, d1fvdd1, d1fvdd2
      part of humanized Fab 4D5, herceptin
    2. 1288631Domain d1fvdc1: 1fvd C:1-107 [19868]
      Other proteins in same PDB: d1fvda2, d1fvdb1, d1fvdb2, d1fvdc2, d1fvdd1, d1fvdd2
      part of humanized Fab 4D5, herceptin
  9. Domain(s) for 1fve:
    1. 1288642Domain d1fvea1: 1fve A:1-107 [19870]
      Other proteins in same PDB: d1fvea2, d1fveb1, d1fveb2, d1fvec2, d1fved1, d1fved2
      part of humanized Fab 4D5, herceptin
    2. 1288643Domain d1fvec1: 1fve C:1-107 [19872]
      Other proteins in same PDB: d1fvea2, d1fveb1, d1fveb2, d1fvec2, d1fved1, d1fved2
      part of humanized Fab 4D5, herceptin
  10. Domain(s) for 1gpo:
    1. 1288604Domain d1gpol1: 1gpo L:1-112 [20224]
      Other proteins in same PDB: d1gpoh1, d1gpoh2, d1gpoi1, d1gpoi2, d1gpol2, d1gpom2
      complexed with so4
    2. 1288605Domain d1gpom1: 1gpo M:1-112 [20226]
      Other proteins in same PDB: d1gpoh1, d1gpoh2, d1gpoi1, d1gpoi2, d1gpol2, d1gpom2
      complexed with so4
  11. Domain(s) for 1i9r:
    1. 1288663Domain d1i9rl1: 1i9r L:1-111 [71155]
      Other proteins in same PDB: d1i9ra_, d1i9rb_, d1i9rc_, d1i9rh1, d1i9rh2, d1i9rk1, d1i9rk2, d1i9rl2, d1i9rm2, d1i9rx1, d1i9rx2, d1i9ry2
      part of humanized Fab 5C8 against C40 ligand
      complexed with zn
    2. 1288664Domain d1i9rm1: 1i9r M:1-111 [71157]
      Other proteins in same PDB: d1i9ra_, d1i9rb_, d1i9rc_, d1i9rh1, d1i9rh2, d1i9rk1, d1i9rk2, d1i9rl2, d1i9rm2, d1i9rx1, d1i9rx2, d1i9ry2
      part of humanized Fab 5C8 against C40 ligand
      complexed with zn
    3. 1288665Domain d1i9ry1: 1i9r Y:1-111 [71161]
      Other proteins in same PDB: d1i9ra_, d1i9rb_, d1i9rc_, d1i9rh1, d1i9rh2, d1i9rk1, d1i9rk2, d1i9rl2, d1i9rm2, d1i9rx1, d1i9rx2, d1i9ry2
      part of humanized Fab 5C8 against C40 ligand
      complexed with zn
  12. Domain(s) for 1it9:
  13. Domain(s) for 1ivl:
    1. 1288609Domain d1ivla_: 1ivl A: [20516]
      VL domain of synthetic antibody M29B; "reversed" dimerisation mode
      complexed with ipa
    2. 1288610Domain d1ivlb_: 1ivl B: [20517]
      VL domain of synthetic antibody M29B; "reversed" dimerisation mode
      complexed with ipa
  14. Domain(s) for 1jps:
  15. Domain(s) for 1jpt:
  16. Domain(s) for 1jv5:
  17. Domain(s) for 1l7i:
  18. Domain(s) for 1mhp:
    1. 1288647Domain d1mhpl1: 1mhp L:2-106 [84969]
      Other proteins in same PDB: d1mhpa_, d1mhpb_, d1mhph1, d1mhph2, d1mhpl2, d1mhpx_
      part of humanized anti-alpha1 integrin I-domain Fab
      complexed with mn
    2. 1288648Domain d1mhpy_: 1mhp Y: [84972]
      Other proteins in same PDB: d1mhpa_, d1mhpb_, d1mhph1, d1mhph2, d1mhpl2, d1mhpx_
      part of humanized anti-alpha1 integrin I-domain Fab; only V domain is ordered
      complexed with mn
  19. Domain(s) for 1n8z:
  20. Domain(s) for 1om3:
    1. 1288622Domain d1om3l1: 1om3 L:2-107 [87063]
      Other proteins in same PDB: d1om3h1, d1om3h2, d1om3k1, d1om3k2, d1om3l2, d1om3m2
      part of engineered Fab 2G12
    2. 1288623Domain d1om3m1: 1om3 M:2-107 [87065]
      Other proteins in same PDB: d1om3h1, d1om3h2, d1om3k1, d1om3k2, d1om3l2, d1om3m2
      part of engineered Fab 2G12
  21. Domain(s) for 1op3:
    1. 1288598Domain d1op3k1: 1op3 K:2-107 [87210]
      Other proteins in same PDB: d1op3h1, d1op3h2, d1op3k2, d1op3l2, d1op3m1, d1op3m2
      part of engineered Fab 2G12
      complexed with bez, man
    2. 1288599Domain d1op3l1: 1op3 L:2-107 [87212]
      Other proteins in same PDB: d1op3h1, d1op3h2, d1op3k2, d1op3l2, d1op3m1, d1op3m2
      part of engineered Fab 2G12
      complexed with bez, man
  22. Domain(s) for 1op5:
    1. 1288666Domain d1op5k1: 1op5 K:2-107 [87218]
      Other proteins in same PDB: d1op5h1, d1op5h2, d1op5k2, d1op5l2, d1op5m1, d1op5m2
      part of engineered Fab 2G12
      complexed with man
    2. 1288667Domain d1op5l1: 1op5 L:2-107 [87220]
      Other proteins in same PDB: d1op5h1, d1op5h2, d1op5k2, d1op5l2, d1op5m1, d1op5m2
      part of engineered Fab 2G12
      complexed with man
  23. Domain(s) for 1pg7:
    1. 1288639Domain d1pg7l1: 1pg7 L:1-107 [94678]
      Other proteins in same PDB: d1pg7h1, d1pg7h2, d1pg7i1, d1pg7i2, d1pg7l2, d1pg7m2, d1pg7w1, d1pg7w2, d1pg7x1, d1pg7x2, d1pg7y1, d1pg7y2, d1pg7z1, d1pg7z2
      part of humanized Fab D3H44 against human tissue factor
    2. 1288640Domain d1pg7m1: 1pg7 M:1-107 [94680]
      Other proteins in same PDB: d1pg7h1, d1pg7h2, d1pg7i1, d1pg7i2, d1pg7l2, d1pg7m2, d1pg7w1, d1pg7w2, d1pg7x1, d1pg7x2, d1pg7y1, d1pg7y2, d1pg7z1, d1pg7z2
      part of humanized Fab D3H44 against human tissue factor
  24. Domain(s) for 1rjl:
  25. Domain(s) for 1s3k:
  26. Domain(s) for 1s78:
    1. 1288668Domain d1s78c1: 1s78 C:1-107 [98624]
      Other proteins in same PDB: d1s78a1, d1s78a2, d1s78a3, d1s78a4, d1s78b1, d1s78b2, d1s78b3, d1s78b4, d1s78c2, d1s78d1, d1s78d2, d1s78e2, d1s78f1, d1s78f2
      part of anti-ERBb2 Fab Pertuzumab
      complexed with nag
    2. 1288669Domain d1s78e1: 1s78 E:1-107 [98628]
      Other proteins in same PDB: d1s78a1, d1s78a2, d1s78a3, d1s78a4, d1s78b1, d1s78b2, d1s78b3, d1s78b4, d1s78c2, d1s78d1, d1s78d2, d1s78e2, d1s78f1, d1s78f2
      part of anti-ERBb2 Fab Pertuzumab
      complexed with nag
  27. Domain(s) for 1t04:
    1. 1288659Domain d1t04a1: 1t04 A:1-108 [112182]
      Other proteins in same PDB: d1t04a2, d1t04b1, d1t04b2, d1t04c2, d1t04d1, d1t04d2
    2. 1288660Domain d1t04c1: 1t04 C:1-108 [112186]
      Other proteins in same PDB: d1t04a2, d1t04b1, d1t04b2, d1t04c2, d1t04d1, d1t04d2
  28. Domain(s) for 1t3f:
  29. Domain(s) for 1tjg:
  30. Domain(s) for 1tjh:
  31. Domain(s) for 1tji:
  32. Domain(s) for 1tzh:
    1. 1288644Domain d1tzha1: 1tzh A:1-107 [107477]
      Other proteins in same PDB: d1tzha2, d1tzhb1, d1tzhb2, d1tzhh1, d1tzhh2, d1tzhl2, d1tzhv_, d1tzhw_
    2. 1288645Domain d1tzhl1: 1tzh L:1-107 [107483]
      Other proteins in same PDB: d1tzha2, d1tzhb1, d1tzhb2, d1tzhh1, d1tzhh2, d1tzhl2, d1tzhv_, d1tzhw_
  33. Domain(s) for 1tzi:
  34. Domain(s) for 1u8h:
  35. Domain(s) for 1u8i:
  36. Domain(s) for 1u8j:
  37. Domain(s) for 1u8k:
  38. Domain(s) for 1u8l:
  39. Domain(s) for 1u8m:
  40. Domain(s) for 1u8n:
  41. Domain(s) for 1u8o:
  42. Domain(s) for 1u8p:
  43. Domain(s) for 1u8q:
  44. Domain(s) for 1u91:
  45. Domain(s) for 1u92:
  46. Domain(s) for 1u93:
  47. Domain(s) for 1u95:
  48. Domain(s) for 1uj3:
  49. Domain(s) for 2f5a:
  50. Domain(s) for 2f5b:
  51. Domain(s) for 2fgw:
  52. Domain(s) for 2imn:
    • 1288593Domain d2imna_: 2imn A: [19856]
      VL domain only of humanized antibody MCPC603
      complexed with act, so4; mutant
  53. Domain(s) for 2pr4:
  54. Domain(s) for 3eyv:
    1. 1288635Domain d3eyvb1: 3eyv B:1-119 [209745]
      Other proteins in same PDB: d3eyva2, d3eyvb2, d3eyvh2, d3eyvl2
      automated match to d1s3kh1
      complexed with gol, zn
    2. 1288636Domain d3eyvh1: 3eyv H:1-119 [209747]
      Other proteins in same PDB: d3eyva2, d3eyvb2, d3eyvh2, d3eyvl2
      automated match to d1s3kh1
      complexed with gol, zn
  55. Domain(s) for 3idg:
  56. Domain(s) for 3idi:
  57. Domain(s) for 3idj:
  58. Domain(s) for 3idm:
  59. Domain(s) for 3idn:
  60. Domain(s) for 3lev:
  61. Domain(s) for 3oau:

More info for Species Engineered (including hybrid species) from b.1.1.1 Immunoglobulin light chain kappa variable domain, VL-kappa

Timeline for Species Engineered (including hybrid species) from b.1.1.1 Immunoglobulin light chain kappa variable domain, VL-kappa:

  • Species Engineered (including hybrid species) from b.1.1.1 Immunoglobulin light chain kappa variable domain, VL-kappa first appeared in SCOP 1.65
  • Species Engineered (including hybrid species) from b.1.1.1 Immunoglobulin light chain kappa variable domain, VL-kappa appears in SCOPe 2.02
  • Species Engineered (including hybrid species) from b.1.1.1 Immunoglobulin light chain kappa variable domain, VL-kappa appears in SCOPe 2.04
  • Species Engineered (including hybrid species) from b.1.1.1 Immunoglobulin light chain kappa variable domain, VL-kappa appears in the current release, SCOPe 2.07