![]() | Class b: All beta proteins [48724] (141 folds) |
![]() | Fold b.1: Immunoglobulin-like beta-sandwich [48725] (22 superfamilies) sandwich; 7 strands in 2 sheets; greek-key some members of the fold have additional strands |
![]() | Superfamily b.1.1: Immunoglobulin [48726] (4 families) ![]() |
![]() | Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (24 proteins) |
![]() | Protein Immunoglobulin light chain kappa variable domain, VL-kappa [88519] (14 species) VL-kappa domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VL-kappa domains with artificial or grafted exogenous CDRs are listed as engineered species |
![]() | Species Engineered (including hybrid species) [88533] (27 PDB entries) |
![]() | Domain d1b2wl1: 1b2w L:1-107 [20306] Other proteins in same PDB: d1b2wh1, d1b2wh2, d1b2wl2 part of a humanized anti-gamma-interferon Fab |
![]() | Domain d1bvka_: 1bvk A: [20278] Other proteins in same PDB: d1bvkb_, d1bvkc_, d1bvke_, d1bvkf_ |
![]() | Domain d1bvkd_: 1bvk D: [20280] Other proteins in same PDB: d1bvkb_, d1bvkc_, d1bvke_, d1bvkf_ part of humanized anti-lysozyme Fv HuLys11 |
![]() | Domain d1bvlb_: 1bvl B: [20283] Other proteins in same PDB: d1bvla_, d1bvlc_ |
![]() | Domain d1bvld_: 1bvl D: [20285] Other proteins in same PDB: d1bvla_, d1bvlc_ part of humanized anti-lysozyme Fv HuLys11 |
![]() | Domain d1fgvl_: 1fgv L: [19852] Other proteins in same PDB: d1fgvh_ part of humanized Fv H52 |
![]() | Domain d1fvca_: 1fvc A: [19862] Other proteins in same PDB: d1fvcb_, d1fvcd_ |
![]() | Domain d1fvcc_: 1fvc C: [19864] Other proteins in same PDB: d1fvcb_, d1fvcd_ part of humanized Fv 4D5, herceptin |
![]() | Domain d1i9rl1: 1i9r L:1-111 [71155] Other proteins in same PDB: d1i9ra_, d1i9rb_, d1i9rc_, d1i9rh1, d1i9rh2, d1i9rk1, d1i9rk2, d1i9rl2, d1i9rm2, d1i9rx1, d1i9rx2, d1i9ry2 |
![]() | Domain d1i9rm1: 1i9r M:1-111 [71157] Other proteins in same PDB: d1i9ra_, d1i9rb_, d1i9rc_, d1i9rh1, d1i9rh2, d1i9rk1, d1i9rk2, d1i9rl2, d1i9rm2, d1i9rx1, d1i9rx2, d1i9ry2 |
![]() | Domain d1i9ry1: 1i9r Y:1-111 [71161] Other proteins in same PDB: d1i9ra_, d1i9rb_, d1i9rc_, d1i9rh1, d1i9rh2, d1i9rk1, d1i9rk2, d1i9rl2, d1i9rm2, d1i9rx1, d1i9rx2, d1i9ry2 part of humanized Fab 5C8 against C40 ligand complexed with zn |
![]() | Domain d1it9l1: 1it9 L:1-111 [76785] Other proteins in same PDB: d1it9h1, d1it9h2, d1it9l2 part of humanized anti-human Fas Fab HFE7A |
![]() | Domain d1ivla_: 1ivl A: [20516] |
![]() | Domain d1ivlb_: 1ivl B: [20517] VL domain of synthetic antibody M29B; "reversed" dimerisation mode complexed with ipa |
![]() | Domain d1jptl1: 1jpt L:1-107 [67053] Other proteins in same PDB: d1jpth1, d1jpth2, d1jptl2 part of humanized Fab D3H44 against human tissue factor |
![]() | Domain d1l7il1: 1l7i L:1-107 [73658] Other proteins in same PDB: d1l7ih1, d1l7ih2, d1l7il2 part of humanized anti-ERBb2 Fab 2C4 complexed with so4 |
![]() | Domain d1mhpl1: 1mhp L:2-106 [84969] Other proteins in same PDB: d1mhpa_, d1mhpb_, d1mhph1, d1mhph2, d1mhpl2, d1mhpx_ part of humanized anti-alpha1 integrin I-domain Fab complexed with mn; mutant |
![]() | Domain d1mhpy_: 1mhp Y: [84972] Other proteins in same PDB: d1mhpa_, d1mhpb_, d1mhph1, d1mhph2, d1mhpl2, d1mhpx_ part of humanized anti-alpha1 integrin I-domain Fab; only V domain is ordered complexed with mn; mutant |
![]() | Domain d1pg7l1: 1pg7 L:1-107 [94678] Other proteins in same PDB: d1pg7h1, d1pg7h2, d1pg7i1, d1pg7i2, d1pg7l2, d1pg7m2, d1pg7w1, d1pg7w2, d1pg7x2, d1pg7y1, d1pg7y2, d1pg7z2 |
![]() | Domain d1pg7m1: 1pg7 M:1-107 [94680] Other proteins in same PDB: d1pg7h1, d1pg7h2, d1pg7i1, d1pg7i2, d1pg7l2, d1pg7m2, d1pg7w1, d1pg7w2, d1pg7x2, d1pg7y1, d1pg7y2, d1pg7z2 part of humanized Fab D3H44 against human tissue factor |
![]() | Domain d1s78c1: 1s78 C:1-107 [98624] Other proteins in same PDB: d1s78a1, d1s78a2, d1s78a3, d1s78a4, d1s78b1, d1s78b2, d1s78b3, d1s78b4, d1s78c2, d1s78d1, d1s78d2, d1s78e2, d1s78f1, d1s78f2 |
![]() | Domain d1s78e1: 1s78 E:1-107 [98628] Other proteins in same PDB: d1s78a1, d1s78a2, d1s78a3, d1s78a4, d1s78b1, d1s78b2, d1s78b3, d1s78b4, d1s78c2, d1s78d1, d1s78d2, d1s78e2, d1s78f1, d1s78f2 part of anti-ERBb2 Fab Pertuzumab complexed with man, nag |
![]() | Domain d2f5al1: 2f5a L:1-107 [88504] Other proteins in same PDB: d2f5ah1, d2f5ah2, d2f5al2 part of humanized HIV-1 neutralizing Fab 2F5 |
![]() | Domain d2f5bl1: 2f5b L:1-107 [88508] Other proteins in same PDB: d2f5bh1, d2f5bh2, d2f5bl2 part of humanized HIV-1 neutralizing Fab 2F5 |
![]() | Domain d2fgwl1: 2fgw L:1-108 [19854] Other proteins in same PDB: d2fgwh1, d2fgwh2, d2fgwl2 part of humanized Fab H52 |
![]() | Domain d2imn__: 2imn - [19856] VL domain only of humanized antibody MCPC603 complexed with ace, so4; mutant |
Timeline for Species Engineered (including hybrid species) from b.1.1.1 Immunoglobulin light chain kappa variable domain, VL-kappa: