Lineage for d2f5bh2 (2f5b H:133-235)

  1. Root: SCOPe 2.03
  2. 1287432Class b: All beta proteins [48724] (174 folds)
  3. 1287433Fold b.1: Immunoglobulin-like beta-sandwich [48725] (28 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 1287434Superfamily b.1.1: Immunoglobulin [48726] (5 families) (S)
  5. 1290587Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 proteins)
  6. 1292198Protein Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma [88574] (6 species)
  7. 1292202Species Human (Homo sapiens) [TaxId:9606] [88575] (177 PDB entries)
    including humanized antibodies (chimeric proteins with human constant domains)
    Uniprot Q6N089 20-243 # 95% sequence identity; natural chimera: antibody heavy chain (Fab HYB3) ! SQ NA # humanized antibody ! Uniprot P01857 # IGHG1_HUMAN Ig gamma-1 chain C region ! SQ NA # engineered antibody
  8. 1292249Domain d2f5bh2: 2f5b H:133-235 [88507]
    Other proteins in same PDB: d2f5bh1, d2f5bl1, d2f5bl2
    part of HIV-1 neutralizing Fab 2F5

Details for d2f5bh2

PDB Entry: 2f5b (more details), 2 Å

PDB Description: crystal structure of fab' from the hiv-1 neutralizing antibody 2f5 in complex with its gp41 epitope
PDB Compounds: (H:) protein (antibody 2f5 (heavy chain))

SCOPe Domain Sequences for d2f5bh2:

Sequence, based on SEQRES records: (download)

>d2f5bh2 b.1.1.2 (H:133-235) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma {Human (Homo sapiens) [TaxId: 9606]}
tstkgpsvfplapsskstaggaaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss
glyslssvvtvpssslgtqtytcnvnhkpsntkvdkrvepksc

Sequence, based on observed residues (ATOM records): (download)

>d2f5bh2 b.1.1.2 (H:133-235) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma {Human (Homo sapiens) [TaxId: 9606]}
tstkgpsvfplapssaggaaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgly
slssvvtvpssslgtqtytcnvnhkpsntkvdkrvepksc

SCOPe Domain Coordinates for d2f5bh2:

Click to download the PDB-style file with coordinates for d2f5bh2.
(The format of our PDB-style files is described here.)

Timeline for d2f5bh2:

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Domains from same chain:
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d2f5bh1