Lineage for d2f5bh1 (2f5b H:1-132)

  1. Root: SCOP 1.69
  2. 450777Class b: All beta proteins [48724] (144 folds)
  3. 450778Fold b.1: Immunoglobulin-like beta-sandwich [48725] (23 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 450779Superfamily b.1.1: Immunoglobulin [48726] (4 families) (S)
  5. 450780Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (27 proteins)
  6. 450916Protein Immunoglobulin heavy chain variable domain, VH [88543] (20 species)
    VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species
  7. 450917Species Engineered (including hybrid species) [88562] (31 PDB entries)
  8. 450930Domain d2f5bh1: 2f5b H:1-132 [88506]
    Other proteins in same PDB: d2f5bh2, d2f5bl1, d2f5bl2
    part of humanized HIV-1 neutralizing Fab 2F5

Details for d2f5bh1

PDB Entry: 2f5b (more details), 2 Å

PDB Description: crystal structure of fab' from the hiv-1 neutralizing antibody 2f5 in complex with its gp41 epitope
PDB Compounds: (H:)

SCOP Domain Sequences for d2f5bh1:

Sequence; same for both SEQRES and ATOM records: (download)

>d2f5bh1 b.1.1.1 (H:1-132) Immunoglobulin heavy chain variable domain, VH {Engineered (including hybrid species)}
ritlkesgpplvkptqtltltcsfsgfslsdfgvgvgwirqppgkalewlaiiysdddkr
yspslntrltitkdtsknqvvlvmtrvspvdtatyfcahrrgpttlfgvpiargpvnamd
vwgqgitvtiss

SCOP Domain Coordinates for d2f5bh1:

Click to download the PDB-style file with coordinates for d2f5bh1.
(The format of our PDB-style files is described here.)

Timeline for d2f5bh1:

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Domains from same chain:
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d2f5bh2