Lineage for d1pkqb2 (1pkq B:114-216)

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2017115Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 2017116Superfamily b.1.1: Immunoglobulin [48726] (5 families) (S)
  5. 2020524Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 protein domains)
  6. 2022294Protein Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma [88574] (6 species)
  7. 2022298Species Human (Homo sapiens) [TaxId:9606] [88575] (179 PDB entries)
    including humanized antibodies (chimeric proteins with human constant domains)
    Uniprot Q6N089 20-243 # 95% sequence identity; natural chimera: antibody heavy chain (Fab HYB3) ! SQ NA # humanized antibody ! Uniprot P01857 # IGHG1_HUMAN Ig gamma-1 chain C region ! SQ NA # engineered antibody
  8. 2022550Domain d1pkqb2: 1pkq B:114-216 [88151]
    Other proteins in same PDB: d1pkqa1, d1pkqa2, d1pkqb1, d1pkqe1, d1pkqe2, d1pkqf1, d1pkqf2, d1pkqg1, d1pkqj1, d1pkqj2
    part of humanized Fab 8-18c5

Details for d1pkqb2

PDB Entry: 1pkq (more details), 3 Å

PDB Description: Myelin Oligodendrocyte Glycoprotein-(8-18C5) Fab-complex
PDB Compounds: (B:) (8-18C5) chimeric Fab, heavy chain

SCOPe Domain Sequences for d1pkqb2:

Sequence; same for both SEQRES and ATOM records: (download)

>d1pkqb2 b.1.1.2 (B:114-216) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d1pkqb2:

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Timeline for d1pkqb2: