SCOPe 2.08: Domain d1p1hb1: 1p1h B:10-322,B:438-533

Lineage for d1p1hb1 (1p1h B:10-322,B:438-533)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.3: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain [51800] (22 proteins)
   family members also share a common alpha+beta fold in C-terminal domain

6. Protein Myo-inositol 1-phosphate synthase [75105] (4 species)

7. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [75107] (9 PDB entries)
   Uniprot P11986

8. Domain d1p1hb1: 1p1h B:10-322,B:438-533 [87677]
   Other proteins in same PDB: d1p1ha2, d1p1hb2, d1p1hc2, d1p1hd2
   complexed with nad
   has additional subdomain(s) that are not in the common domain

Details for d1p1hb1

PDB Entry: 1p1h, 1.95 Å

PDB Description: Crystal structure of the 1L-myo-inositol/NAD+ complex

PDB Compounds: (B:) Inositol-3-phosphate synthase

SCOPe Domain Sequences for d1p1hb1:

Sequence, based on SEQRES records:

>d1p1hb1 c.2.1.3 (B:10-322,B:438-533) Myo-inositol 1-phosphate synthase {Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]}
tsvkvvtdkctykdnelltkysyenavvtktasgrfdvtptvqdyvfkldlkkpeklgim
liglggnngstlvasvlankhnvefqtkegvkqpnyfgsmtqcstlklgidaegndvyap
fnsllpmvspndfvvsgwdinnadlyeamqrsqvleydlqqrlkakmslvkplpsiyypd
fiaanqderanncinldekgnvttrgkwthlqrirrdiqnfkeenaldkvivlwtanter
yvevspgvndtmenllqsikndheeiapstifaaasilegvpyingspqntfvpglvqla
ehegtfiagddlkXdsllatpliidllvmtefctrvsykkvdpvkedagkfenfypvltf
lsywlkapltrpgfhpvnglnkqrtalenflrlliglpsqnelrfeerll

Sequence, based on observed residues (ATOM records):

>d1p1hb1 c.2.1.3 (B:10-322,B:438-533) Myo-inositol 1-phosphate synthase {Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]}
tsvkvvtdkctykdnelltkysyenavvtktasgrfdvtptvqdyvfkldlkkpeklgim
liglggnngstlvasvlankhnvefqtkegvkqpnyfgsmtqcstlklgidaegndvyap
fnsllpmvspndfvvsgwdinnadlyeamqrsqvleydlqqrlkakmslvkplpsiyypd
fiaanqderanncinldekgnvttrgkwthlqrirrdiqnfkeenaldkvivlwtanter
yvevspgvndtmenllqsikndheeiapstifaaasilegvpyingspqntfvpglvqla
ehegtfiagddlkXdsllatpliidllvmtefctrvsykkvgkfenfypvltflsywlka
pltrpgfhpvnglnkqrtalenflrlliglpsqnelrfeerll

Timeline for d1p1hb1:

• d1p1hb1 first appeared in SCOP 1.65
  
• d1p1hb1 appears in SCOPe 2.07