SCOP 1.73: Domain d1p14a_: 1p14 A:

Lineage for d1p14a_ (1p14 A:)

1. Root: SCOP 1.73

2. Class d: Alpha and beta proteins (a+b) [53931] (334 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (7 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (61 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Insulin receptor [56162] (1 species)
   PTK group; InsR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56163] (8 PDB entries)

8. Domain d1p14a_: 1p14 A: [87660]
   mutant

Details for d1p14a_

PDB Entry: 1p14, 1.9 Å

PDB Description: crystal structure of a catalytic-loop mutant of the insulin receptor tyrosine kinase

PDB Compounds: (A:) Insulin receptor

SCOP Domain Sequences for d1p14a_:

Sequence, based on SEQRES records:

>d1p14a_ d.144.1.7 (A:) Insulin receptor {Human (Homo sapiens) [TaxId: 9606]}
vfpssvyvpdewevsrekitllrelgqgsfgmvyegnardiikgeaetrvavktvnesas
lrerieflneasvmkgftchhvvrllgvvskgqptlvvmelmahgdlksylrslrpeaen
npgrppptlqemiqmaaeiadgmaylnakkfvhrnlaarncmvahdftvkigdfgmtrdi
yetdyyrkggkgllpvrwmapeslkdgvfttssdmwsfgvvlweitslaeqpyqglsneq
vlkfvmdggyldqpdncpervtdlmrmcwqfnpnmrptfleivnllkddlhpsfpevsff
hseenk

Sequence, based on observed residues (ATOM records):

>d1p14a_ d.144.1.7 (A:) Insulin receptor {Human (Homo sapiens) [TaxId: 9606]}
vfpssvyvpdewevsrekitllrelgqgsfgmvyegnardiikgeaetrvavktvnesas
lrerieflneasvmkgftchhvvrllgvvskgqptlvvmelmahgdlksylrslrpeaen
npgrppptlqemiqmaaeiadgmaylnakkfvhrnlaarncmvahdftvkigdfgpvrwm
apeslkdgvfttssdmwsfgvvlweitslaeqpyqglsneqvlkfvmdggyldqpdncpe
rvtdlmrmcwqfnpnmrptfleivnllkddlhpsfpevsffhseenk

Timeline for d1p14a_:

• d1p14a_ first appeared in SCOP 1.65
  
• d1p14a_ appears in SCOP 1.71
  
• d1p14a_ appears in SCOP 1.75
  
• d1p14a_ appears in the current release, SCOPe 2.08