SCOPe 2.07: Domain d1oy0a_: 1oy0 A:

Lineage for d1oy0a_ (1oy0 A:)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.12: Phosphoenolpyruvate/pyruvate domain [51621] (8 families)

5. Family c.1.12.8: Ketopantoate hydroxymethyltransferase PanB [89503] (2 proteins)
   automatically mapped to Pfam PF02548

6. Protein Ketopantoate hydroxymethyltransferase PanB [89504] (3 species)
   dodecameric enzyme; a C-terminal helix exchange is observed in the M. tuberculosis enzyme but not in the E. coli enzyme

7. Species Mycobacterium tuberculosis [TaxId:1773] [89505] (1 PDB entry)

8. Domain d1oy0a_: 1oy0 A: [87543]
   complexed with mg

Details for d1oy0a_

PDB Entry: 1oy0, 2.8 Å

PDB Description: The crystal Structure of the First Enzyme of Pantothenate Biosynthetic Pathway, Ketopantoate Hydroxymethyltransferase from Mycobacterium Tuberculosis Shows a Decameric Assembly and Terminal Helix-Swapping

PDB Compounds: (A:) Ketopantoate hydroxymethyltransferase

SCOPe Domain Sequences for d1oy0a_:

Sequence, based on SEQRES records:

>d1oy0a_ c.1.12.8 (A:) Ketopantoate hydroxymethyltransferase PanB {Mycobacterium tuberculosis [TaxId: 1773]}
rtkirthhlqrwkadghkwamltaydystarifdeagipvllvgdsaanvvygydttvpi
sideliplvrgvvrgaphalvvadlpfgsyeagptaalaaatrflkdggahavklegger
vaeqiacltaagipvmahigftpqsvntlggfrvqgrgdaaeqtiadaiavaeagafavv
memvpaelatqitgkltiptvgigagpncdgqvlvwqdmagfsgaktarfvkryadvgge
lrraamqyaqevaggvfpadeh

Sequence, based on observed residues (ATOM records):

>d1oy0a_ c.1.12.8 (A:) Ketopantoate hydroxymethyltransferase PanB {Mycobacterium tuberculosis [TaxId: 1773]}
rtkirthhlqrwkadghkwamltaydystarifdeagipvllvgdsaanvvygydttvpi
sideliplvrgvvrgaphalvvadlpfgsyeagptaalaaatrflkdggahavklegger
vaeqiacltaagipvmahigftpgdaaeqtiadaiavaeagafavvmemvpaelatqitg
kltiptvgigagpncdgqvlvwqdmagfsgaktarfvkryadvggelrraamqyaqevag
gvfpadeh

Timeline for d1oy0a_:

• d1oy0a_ first appeared in SCOP 1.65
  
• d1oy0a_ appears in SCOPe 2.06
  
• d1oy0a_ appears in the current release, SCOPe 2.08