SCOPe 2.08: Domain d1ox4a1: 1ox4 A:230-550

Lineage for d1ox4a1 (1ox4 A:230-550)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (34 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.2: Ribulose-phoshate binding barrel [51366] (7 families)

5. Family c.1.2.1: Histidine biosynthesis enzymes [51367] (3 proteins)
   structural evidence for the gene duplication within the barrel fold
   automatically mapped to Pfam PF00977

6. Protein Cyclase subunit (or domain) of imidazoleglycerolphosphate synthase HisF [51370] (4 species)

7. Species Baker's yeast (Saccharomyces cerevisiae), His7 [TaxId:4932] [69379] (4 PDB entries)

8. Domain d1ox4a1: 1ox4 A:230-550 [87497]
   Other proteins in same PDB: d1ox4a2, d1ox4a3, d1ox4b2, d1ox4b3
   complexed with ni, pop, so4

Details for d1ox4a1

PDB Entry: 1ox4, 2.5 Å

PDB Description: towards understanding the mechanism of the complex cyclization reaction catalyzed by imidazole glycerophosphate synthase

PDB Compounds: (A:) Imidazole glycerol phosphate synthase hisHF

SCOPe Domain Sequences for d1ox4a1:

Sequence, based on SEQRES records:

>d1ox4a1 c.1.2.1 (A:230-550) Cyclase subunit (or domain) of imidazoleglycerolphosphate synthase HisF {Baker's yeast (Saccharomyces cerevisiae), His7 [TaxId: 4932]}
dysnygltrriiacldvrtndqgdlvvtkgdqydvreksdgkgvrnlgkpvqlaqkyyqq
gadevtflnitsfrdcplkdtpmlevlkqaaktvfvpltvgggikdivdvdgtkipalev
aslyfrsgadkvsigtdavyaaekyyelgnrgdgtspietiskaygaqavvisvdpkrvy
vnsqadtknkvfeteypgpngekycwyqctikggresrdlgvweltracealgageilln
cidkdgsnsgydleliehvkdavkipviassgagvpehfeeaflktradaclgagmfhrg
eftvndvkeyllehglkvrmd

Sequence, based on observed residues (ATOM records):

>d1ox4a1 c.1.2.1 (A:230-550) Cyclase subunit (or domain) of imidazoleglycerolphosphate synthase HisF {Baker's yeast (Saccharomyces cerevisiae), His7 [TaxId: 4932]}
dysnygltrriiacldvrtndqgdlvvtkgdlgkpvqlaqkyyqqgadevtflnitcplk
dtpmlevlkqaaktvfvpltvgggikdivdvdgtkipalevaslyfrsgadkvsigtdav
yaaekyyelgnrgdgtspietiskaygaqavvisvdpkrvyvnsqadtknkvfeteypgp
ngekycwyqctikggresrdlgvweltracealgageillncidkdgsnsgydleliehv
kdavkipviassgagvpehfeeaflktradaclgagmfhrgeftvndvkeyllehglkvr
md

Timeline for d1ox4a1:

• d1ox4a1 first appeared in SCOP 1.65
  
• d1ox4a1 appears in SCOPe 2.07