SCOP 1.71: Domain d1o7d.2: 1o7d C:488-585,D:603-875,E:885-1007

Lineage for d1o7d.2 (1o7d C:488-585,D:603-875,E:885-1007)

1. Root: SCOP 1.71

2. Class b: All beta proteins [48724] (149 folds)

3. Fold b.30: Supersandwich [49993] (3 superfamilies)
   sandwich; 18 strands in 2 sheets

4. Superfamily b.30.5: Galactose mutarotase-like [74650] (11 families)
   probable carbohydrate-binding domain in enzymes acting on sugars

5. Family b.30.5.6: alpha-mannosidase, C-terminal domain [88656] (2 proteins)
   family 38 glycoside hydrolase; overall domain organization is similar to that of the 4-alpha-glucanotransferase family
   the supersandwich domain is elaborated with additional beta-strands and beta-sandwich subdomains

6. Protein Lysosomal alpha-mannosidase [89289] (1 species)
   the single-chain precursor is processed into 5 peptides; heavily glycosylated

7. Species Cow (Bos taurus) [TaxId:9913] [89290] (1 PDB entry)

8. Domain d1o7d.2: 1o7d C:488-585,D:603-875,E:885-1007 [86640]
   Other proteins in same PDB: d1o7d.1, d1o7d.3
   complexed with bma, man, nag, ndg, so4, trs, zn

Details for d1o7d.2

PDB Entry: 1o7d, 2.7 Å

PDB Description: the structure of the bovine lysosomal a-mannosidase suggests a novel mechanism for low ph activation

SCOP Domain Sequences for d1o7d.2:

Sequence, based on SEQRES records:

>g1o7d.2 b.30.5.6 (C:488-585,D:603-875,E:885-1007) Lysosomal alpha-mannosidase {Cow (Bos taurus)}
edfafcrklnisicpltqtaerfqvivynplgrkvdwmvrlpvskhvylvkdpggkivps
dvvtipssdsqellfsalvpavgfsiysvsqmpnXrdlviqneylrarfdpntgllmele
nleqnlllpvrqafywynastgnnlssqasgayifrpnqnkplfvshwaqthlvkaslvq
evhqnfsawcsqvvrlyprqrhlelewtvgpipvgdgwgkevisrfdtalatrglfytds
ngreilerrrnyrptwklnqtepvagnyypvnsriyitdgnmqltvltdrsqggsslrdg
slelmvhrrllkddargvgeplnkegsglwvrgrhlvlldkketaaarhrlqaemevlap
qvvlaqggXprtqfsglrrelppsvrlltlarwgpetlllrlehqfavgedsgrnlsspv
tldltnlfsaftitnlrettlaanqllayasrlqwttdtgptphpspsrpvsatitlqpm
eirtflasvqwe

Sequence, based on observed residues (ATOM records):

>g1o7d.2 b.30.5.6 (C:488-585,D:603-875,E:885-1007) Lysosomal alpha-mannosidase {Cow (Bos taurus)}
edfafcrklnisicpltqtaerfqvivynplgrkvdwmvrlpvskhvylvkdpggkivps
dvvtipssdsqellfsalvpavgfsiysvsqmpnXrdlviqneylrarfdpntgllmele
nllllpvrqafywynastgnnlssqasgayifrpnqnkplfvshwaqthlvkaslvqevh
qnfsawcsqvvrlyprqrhlelewtvgpipvgdgwgkevisrfdtalatrglfytdsngr
eilerrrnyrptwklnqtepvagnyypvnsriyitdgnmqltvltdrsqggsslrdgsle
lmvhrrllkddargvgeplnkegsglwvrgrhlvlldkketaaarhrlqaemevlapqvv
laqggXprtqfsglrrelppsvrlltlarwgpetlllrlehqfavgedsgrnlsspvtld
ltnlfsaftitnlrettlaanqllayasrlqwttdatitlqpmeirtflasvqwe

Timeline for d1o7d.2:

• d1o7d.2 first appeared in SCOP 1.65
  
• d1o7d.2 appears in SCOP 1.69
  
• d1o7d.2 appears in SCOP 1.73
  
• d1o7d.2 appears in the current release, SCOPe 2.08