SCOPe 2.02: Domain d1nvxs_: 1nvx S:

Lineage for d1nvxs_ (1nvx S:)

1. Root: SCOPe 2.02

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.117: Ras GEF [48365] (1 superfamily)
   multihelical

4. Superfamily a.117.1: Ras GEF [48366] (1 family)

5. Family a.117.1.1: Ras GEF [48367] (1 protein)

6. Protein Son of sevenless protein homolog 1 (sos-1) [48368] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48369] (9 PDB entries)
   Uniprot Q07889 189-1046

8. Domain d1nvxs_: 1nvx S: [86285]
   Other proteins in same PDB: d1nvxq_, d1nvxr_
   complexed with gtp, mg, po4

Details for d1nvxs_

PDB Entry: 1nvx, 3.2 Å

PDB Description: structural evidence for feedback activation by rasgtp of the ras- specific nucleotide exchange factor sos

PDB Compounds: (S:) Son of sevenless protein homolog 1

SCOPe Domain Sequences for d1nvxs_:

Sequence, based on SEQRES records:

>d1nvxs_ a.117.1.1 (S:) Son of sevenless protein homolog 1 (sos-1) {Human (Homo sapiens) [TaxId: 9606]}
qmrlpsadvyrfaepdseeniifeenmqpkagipiikagtviklierltyhmyadpnfvr
tflttyrsfckpqellsliierfeipepepteadriaiengdqplsaelkrfrkeyiqpv
qlrvlnvcrhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkkiard
ngpghnitfqsspptvewhisrpghietfdlltlhpieiarqltllesdlyravqpselv
gsvwtkedkeinspnllkmirhttnltlwfekcivetenleervavvsriieilqvfqel
nnfngvlevvsamnsspvyrldhtfeqipsrqkkileeahelsedhykkylaklrsinpp
cvpffgiyltnilkteegnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpyclrves
dikrffenlnpmgnsmekeftdylfnksleieprnpkplprfpkkysyplkspgvrpsn

Sequence, based on observed residues (ATOM records):

>d1nvxs_ a.117.1.1 (S:) Son of sevenless protein homolog 1 (sos-1) {Human (Homo sapiens) [TaxId: 9606]}
qmrlpsadvyrfaepdseeniifeegipiikagtviklierltyhmyadpnfvrtfltty
rsfckpqellsliierfeipepelkrfrkeyiqpvqlrvlnvcrhwvehhfydferdayl
lqrmeefigtvrgkamkkwvesitkiiqrkkiahnitfqsspptvewhisrpghietfdl
ltlhpieiarqltllesdlyravqpselvgsvwtkedkeinspnllkmirhttnltlwfe
kcivetenleervavvsriieilqvfqelnnfngvlevvsamnsspvyrldhtfeqipsr
qkkileeahelsedhykkylaklrsinppcvpffgiyltnilkteegnpevlkrhgkeli
nfskrrkvaeitgeiqqyqnqpyclrvesdikrffenlnpmgnsmekeftdylfnkslei
eprnpkplprfpkkysyplkspgvrpsn

Timeline for d1nvxs_:

• d1nvxs_ first appeared in SCOP 1.65
  
• d1nvxs_ appears in SCOPe 2.01
  
• d1nvxs_ appears in SCOPe 2.03
  
• d1nvxs_ appears in the current release, SCOPe 2.08